Zobrazeno 1 - 10
of 997
pro vyhledávání: '"Hsp104"'
Multiple aspects of amyloid dynamics in vivo integrate to establish prion variant dominance in yeast
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Prion variants are self-perpetuating conformers of a single protein that assemble into amyloid fibers and confer unique phenotypic states. Multiple prion variants can arise, particularly in response to changing environments, and interact within an or
Externí odkaz:
https://doaj.org/article/09163c51c3bd47b7b5afff72eac803e7
Autor:
Samantha J. Ganser, Bridget A. McNish, Gillian L. Schwanitz, John L. Delaney, Bridget A. Corpus, Brenda A. Schilke, Anup K. Biswal, Chandan Sahi, Elizabeth A. Craig, Justin K. Hines
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
J-domain proteins (JDPs) are obligate cochaperones of Hsp70s. The Class A JDP Apj1 of the yeast cytosol has an unusually complex region between the N-terminal J-domain and the substrate binding region—often called the Grich or GF region in Class A
Externí odkaz:
https://doaj.org/article/d1fe474f7674468bb48d114d8a70c204
Akademický článek
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Autor:
Adam S. Knier, Emily E. Davis, Hannah E. Buchholz, Jane E. Dorweiler, Lauryn E. Flannagan, Anita L. Manogaran
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Patients with the fatal disorder Transthyretin Amyloidosis (ATTR) experience polyneuropathy through the progressive destruction of peripheral nervous tissue. In these patients, the transthyretin (TTR) protein dissociates from its functional tetrameri
Externí odkaz:
https://doaj.org/article/2e5013c89f9c4db9a0cc7fdc6ee85038
Autor:
Jintana Wongwigkarn
Publikováno v:
Warasan Witthayasat Lae Theknoloyi Mahawitthayalai Mahasarakham, Vol 39, Iss 1, Pp 113-126 (2020)
Molecular chaperone Hsp104, also known as heat shock protein in yeast Saccharomyces cerevisiae, plays an essential role in thermotorelance response enabling yeast cell survival at high temperature. Hsp104 mediates the misfolding and the aggregation
Externí odkaz:
https://doaj.org/article/186c37dda1974f78801ce78765dc747c
Akademický článek
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Autor:
Chih-Yen King
Publikováno v:
Viruses, Vol 14, Iss 11, p 2337 (2022)
Prions replicate by a self-templating mechanism. Infidelity in the process can lead to the emergence of new infectious structures, referred to as variants or strains. The question of whether prions are prone to mis-templating is not completely answer
Externí odkaz:
https://doaj.org/article/d1c3bcfb0cfb444f978dfed3ae0cb697
Autor:
Huiqing Xia, Linlin Chen, Zhuo Fan, Mengya Peng, Jingya Zhao, Wenbo Chen, Haiyang Li, Yan Shi, Shengli Ding, Honglian Li
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Heat shock protein Hsp104, a homolog of the bacterial chaperone ClpB and plant Hsp100, plays an essential part in the response to heat and various chemical agents in Saccharomyces cerevisiae. However, their functions remain largely unknown in plant f
Externí odkaz:
https://doaj.org/article/dcfb1f8dfea2439d89c9e55df5999c62
Autor:
Jane E. Dorweiler, Douglas R. Lyke, Nathan P. Lemoine, Samantha Guereca, Hannah E. Buchholz, Emily R. Legan, Claire M. Radtke, Anita L. Manogaran
Publikováno v:
Viruses, Vol 14, Iss 7, p 1581 (2022)
Yeast prions are self-perpetuating misfolded proteins that are infectious. In yeast, [PSI+] is the prion form of the Sup35 protein. While the study of [PSI+] has revealed important cellular mechanisms that contribute to prion propagation, the underly
Externí odkaz:
https://doaj.org/article/fe2e1a6a83314e17a2265569b9b6ab76
Akademický článek
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