Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis

Autor: Xiaoying Zhou, Shengchun Jin, Jingyi Pan, Qingyi Lin, Shaopeng Yang, Peter C. Ambe, Zarrin Basharat, Vincent Zimmer, Wei Wang, Wandong Hong

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Previous researches have emphasized a trypsin-centered theory of acute pancreatitis (AP) for more than a century. With additional studies into the pathogenesis of AP, new mechanisms have been explored. Among them, the role of immune response bears gr

Externí odkaz: https://doaj.org/article/953b607910aa4176acacaf73388000f4

Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney Disease

Autor: Vartika Tomar, Liudmila Cebotaru, Murali K. Yanda

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1517-1529 (2021)

Background & Aims Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in PKHD1, encoding fibrocystin/polyductin (FPC). Severe disease occurs in perinates. Those who survive the neonatal period face a myriad of comorbidities,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaad8f75a984645da5b03d61f582973
http://europepmc.org/articles/PMC8529398

Magnetic systems for cancer immunotherapy

Autor: William C. Wixson, Nicole B. Day, C. Wyatt Shields

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2172-2196 (2021)

Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies. Immune cell modulation through the administration of drugs, proteins, and cells can enhance an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35de5eede84d436e4c319659616fdaea
http://europepmc.org/articles/PMC8424374

Chaperones and Ubiquitin Ligases Balance Mutant p53 Protein Stability in Esophageal and Other Digestive Cancers

Autor: Theodore S. Lawrence, May San Martinho, Derek J. Nancarrow, Dipankar Ray, David G. Beer

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology

The incidence of esophageal adenocarcinoma (EAC) and other gastrointestinal (GI) cancers have risen dramatically, thus defining the oncogenic drivers to develop effective therapies are necessary. Patients with Barrett's Esophagus (BE), have an elevat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb8b4a5877a31843d9d41138bf96cb2
https://doi.org/10.1016/j.jcmgh.2020.10.012

Malondialdehyde Conjugated With Albumin Induces Pro-Inflammatory Activation of T Cells Isolated From Human Atherosclerotic Plaques Both Directly and Via Dendritic Cell–Mediated Mechanism

Autor: Ákos Végvári, Johnny Steuer, Mizanur Rahman, Johan Frostegård, Anquan Liu, Peter Gillgren

Publikováno v: JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 4, Pp 480-494 (2019)

Visual Abstract
Highlights • MDA conjugated with HSA activates T cells from human atherosclerotic plaques through a direct mechanism. • MDA-HSA also induces maturation and activation of human dendritic cells, which in turn promote activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96508a65f6dd269c2d29fb4f688619a4
https://doi.org/10.1016/j.jacbts.2019.03.009