Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Hsiu-Ming SHIH"'
Autor:
Hsieh-Tsung Shen, Chin-Sheng Hung, Clilia Davis, Chih-Ming Su, Li-Min Liao, Hsiu-Ming Shih, Kuan-Der Lee, Muhamad Ansar, Ruo-Kai Lin
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 571 (2024)
Breast cancer is a leading cause of cancer mortality in women worldwide. Using the Infinium MethylationEPIC BeadChip, we analyzed plasma sample methylation to identify the SRCIN1 gene in breast cancer patients. We assessed SRCIN1-related roles and pa
Externí odkaz:
https://doaj.org/article/0673084bb3234102bbb1eac3a4244be8
Autor:
Tsan-Tzu Yang, Ming-Feng Chiang, Che-Chang Chang, Shii-Yi Yang, Shih-Wen Huang, Nan-Shih Liao, Hsiu-Ming Shih, Wei Hsu, Kuo-I Lin
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract The molecular mechanisms contributing to the regulation of Th17-mediated inflammation remain underexplored. We here report a SUMO-specific protease (SENP)2-mediated pathway induced in pathogenic Th17 cells that restricts the pathogenesis of
Externí odkaz:
https://doaj.org/article/70266b1582b0403d8359af9113548e48
Publikováno v:
Genes to Cells. 28:188-201
The nuclear pore complex (NPC) provides a permeable barrier between the nucleoplasm and cytoplasm. In a subset of NPC constituents that regulate meiosis in the fission yeast Schizosaccharomyces pombe, we found that nucleoporin Nup132 (homolog of huma
Autor:
Hsuan-Yin Ma, Chun-Yi Lu, Kuo-Chien Tsao, Hsiu-Ming Shih, Ai-Ling Cheng, Li-Min Huang, Luan-Yin Chang
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 51, Iss 5, Pp 608-613 (2018)
Objectives: Enterovirus 71 (EV71) may cause neurological and fatal cases. EV71 3C plays an important role on viral replication and possess proteolysis activity. To delineate pathogenesis of EV71 virulence, we studied EV71 3C genetics, protease activi
Externí odkaz:
https://doaj.org/article/6f8cc7a631cb46e1a73f0f99145d5386
Autor:
Yung-Lin Hsieh, Fang-Yi Su, Li-Kai Tsai, Chien-Chang Huang, Yi-Ling Ko, Li-Wen Su, Kai-Yun Chen, Hsiu-Ming Shih, Chun-Mei Hu, Wen-Hwa Lee
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2134-2143.e7 (2019)
Summary: Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, usually occurs in middle-aged people. However, the molecular basis of age-related cumulative stress in ALS pathogenesis remains elusive. Here, we found that mice defi
Externí odkaz:
https://doaj.org/article/22eb0f2bbc8d4995b37c7c23f0680a3f
Autor:
Ching‐Yu Lin, Shun‐Tai Yang, Shing‐Chuan Shen, Yi‐Chen Hsieh, Fei‐Ting Hsu, Cheng‐Yu Chen, Yung‐Hsiao Chiang, Jian‐Ying Chuang, Kai‐Yun Chen, Tsung‐I Hsu, Wan‐Chong Leong, Yu‐Kai Su, Wei‐Lun Lo, Yi‐Shian Yeh, Yudha Nur Patria, Hsiu‐Ming Shih, Che‐Chang Chang, Szu‐Yi Chou
Publikováno v:
Molecular Oncology, Vol 12, Iss 5, Pp 756-771 (2018)
Glioblastoma multiforme (GBM) is a highly malignant type of brain tumor found in humans. GBM cells reproduce quickly, and the median survival time for patients after therapy is approximately 1 year with a high relapse rate. Current therapies and diag
Externí odkaz:
https://doaj.org/article/bc535ccfd9814d4ca341a341e8391a1e
The HMGA2 architectural protein functions in a variety of cellular processes, such as cell growth, transcription regulation, neoplastic transformation, and progression. Up-regulation of HMGA2 protein is observed in many tumors and is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269cf221d795724c8a08192f9ea7b8e0
https://doi.org/10.1158/1535-7163.c.6530915.v1
https://doi.org/10.1158/1535-7163.c.6530915.v1
Supplementary Figure 1 from SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b6d9925deb088cf385b855724b9983
https://doi.org/10.1158/1535-7163.22482398.v1
https://doi.org/10.1158/1535-7163.22482398.v1
Autor:
Kun Ping Lu, Hsiu-Ming Shih, Xiao Zhen Zhou, Ruey-Hwa Chen, Fu-An Li, Shuo Wei, Pei-Hsin Liao, Pengyu Huang, ManLi Luo, Tae Ho Lee, Che-Chang Chang, Chun-Hau Chen
The Pin1 prolyl isomerase regulates phosphorylation signaling by controlling protein conformation after phosphorylation, and its upregulation promotes oncogenesis via acting on numerous oncogenic molecules. SUMOylation and deSUMOylation are dynamic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46c9b9bd2aeb413b53627d3cb8df3596
https://doi.org/10.1158/0008-5472.c.6503966.v1
https://doi.org/10.1158/0008-5472.c.6503966.v1
Autor:
Kun Ping Lu, Hsiu-Ming Shih, Xiao Zhen Zhou, Ruey-Hwa Chen, Fu-An Li, Shuo Wei, Pei-Hsin Liao, Pengyu Huang, ManLi Luo, Tae Ho Lee, Che-Chang Chang, Chun-Hau Chen
Supplementary Figures - PDF file 635K, Supplementary Figure S1. Pin1 is modified on Lys6 and Lys63 by SUMO1 in vitro and in vivo. Supplementary Figure S2. Pin1 Lys6 and Lys63 mutations increase its ability to active cyclin D1 promoter and stabilize c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2410d3389d802605f7a9f96ee2ac2d7c
https://doi.org/10.1158/0008-5472.22394162
https://doi.org/10.1158/0008-5472.22394162