Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Hsiu-Chiung Yang"'
Autor:
Joseph D. Ho, Betty Chau, Logan Rodgers, Frances Lu, Kelly L. Wilbur, Keith A. Otto, Yanyun Chen, Min Song, Jonathan P. Riley, Hsiu-Chiung Yang, Nichole A. Reynolds, Steven D. Kahl, Anjana Patel Lewis, Christopher Groshong, Russell E. Madsen, Kris Conners, Jayana P. Lineswala, Tarun Gheyi, Melbert-Brian Decipulo Saflor, Matthew R. Lee, Jordi Benach, Kenton A. Baker, Chahrzad Montrose-Rafizadeh, Michael J. Genin, Anne R. Miller, Chafiq Hamdouchi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
GPR40 is a G-protein coupled receptor that binds to free fatty acids, mediating insulin and incretin secretion. Here, the authors present the crystal structure of human GPR40 with an agonist bound to an allosteric site located near the lipid-rich reg
Externí odkaz:
https://doaj.org/article/5d745f39e74e44df919e15e9433e1c33
Autor:
Elmar Zügner, Hsiu-Chiung Yang, Petra Kotzbeck, Beate Boulgaropoulos, Harald Sourij, Sepideh Hagvall, Charles S. Elmore, Russell Esterline, Sven Moosmang, Jan Oscarsson, Thomas R. Pieber, Xiao-Rong Peng, Christoph Magnes
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7966
(1) The cardio-reno-metabolic benefits of the SGLT2 inhibitors canagliflozin (cana), dapagliflozin (dapa), ertugliflozin (ertu), and empagliflozin (empa) have been demonstrated, but it remains unclear whether they exert different off-target effects i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077568d1b6dab0b11bcd16983a9fe3a4
Publikováno v:
Cardiovascular drugs and therapy. 36(6)
Background SGLT2 inhibitors increase plasma ketone concentrations. It has been suggested that insulinopenia, along with an increase in the counter-regulatory hormones epinephrine, corticosterone, glucagon and growth hormone, can induce ketoacidosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0797d6fdf3d117bd3f0558b7c33ecab0
https://pubmed.ncbi.nlm.nih.gov/34448973
https://pubmed.ncbi.nlm.nih.gov/34448973
Publikováno v:
Diabetes. 70
Sodium glucose cotransporter-2 (SGLT2) inhibitors promote urinary glucose excretion, consequently reducing blood glucose. Previously we showed that 6 weeks of Dapagliflozin (Dapa) treatment improved insulin sensitivity and prevented weight gain. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0b996d647778d2fa7bdad8bd7d12b01
https://doi.org/10.2337/db21-120-or
https://doi.org/10.2337/db21-120-or
Autor:
Richard N. Bergman, Morvarid Kabir, Hsiu-Chiung Yang, Darko Stefanovski, V. Sashi Gopaul, Cathryn M. Kolka, Francesca Piccinini
Publikováno v:
Diabetes. 69
Selective sodium glucose cotransporter-2 inhibition promotes urinary glucose excretion, thus reducing blood glucose. Previously we showed that 6 weeks of Dapagliflozin (Dapa) treatment improved insulin sensitivity and prevented weight gain in a canin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17090d73a992d48befac916426ef3b8a
https://doi.org/10.2337/db20-1711-p
https://doi.org/10.2337/db20-1711-p
Publikováno v:
Cardiovascular drugs and therapy. 34(4)
Ticagrelor, a P2Y12 receptor antagonist, and dapagliflozin, a sodium–glucose-cotransporter-2 inhibitor, suppress the activation of the NLRP3 inflammasome. The anti-inflammatory effects of dapagliflozin depend on AMPK activation. Also, ticagrelor ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0cc110c5d1e07aac2f7086f753ac24
https://pubmed.ncbi.nlm.nih.gov/32335797
https://pubmed.ncbi.nlm.nih.gov/32335797
Publikováno v:
Cardiovascular Drugs and Therapy. 32:135-145
Sodium-glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 inhibitors (DPP4I) are used to treat type 2 diabetes (T2DM). DPP4 inhibitors (DPP4) attenuate Nlrp3 inflammasome activation in the kidney. SGLT2 inhibition reduces inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9836965c246e42e8eb657c70a14417a
https://doi.org/10.1007/s10557-018-6778-x
https://doi.org/10.1007/s10557-018-6778-x
Autor:
José Francisco Soriano, Javier Agejas, Rosario Gonzalez, Ramón Rodríguez, Timothy B. Durham, Howard Barff Broughton, Juan F. Espinosa, Paloma Vidal, Ana B. Bueno, Robert Dean Dally, Hsiu-Chiung Yang, Alicia Marcos, David E. Timm, Gema Sanz, James R. McCarthy, Patric James Hahn
Publikováno v:
Journal of Medicinal Chemistry. 60:9807-9820
NMR conformational analysis of a hydroxyethylamine peptide isostere developed as an aspartic protease inhibitor shows that it is a flexible architecture. Cyclization to form pyrrolidines, piperidines, or morpholines results in a preorganization of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c3ae5f96ab4869e6ec456bade5b1dc
https://doi.org/10.1021/acs.jmedchem.7b01304
https://doi.org/10.1021/acs.jmedchem.7b01304
Autor:
Jacob R. Enriquez, Carey L. Watson, Heather A. McCauley, Nichole A. Reynolds, Hsiu-Chiung Yang, Katie L. Sinagoga, Jorge O. Múnera, James M. Wells, Michael A. Helmrath
Enteroendocrine cells (EECs) are a minor cell population in the intestine yet they play a major role in digestion, satiety and nutrient homeostasis. Recently developed human intestinal organoid models include EECs, but their rarity makes it difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39b72287aabaec973a8abcecef0f048
https://europepmc.org/articles/PMC6198470/
https://europepmc.org/articles/PMC6198470/
Autor:
Richard N. Bergman, Rebecca L. Paszkiewicz, Stella P. Kim, V. Sashi Gopaul, Ivan Formentini, Hasmik Mkrtchyan, Eva Lundborg, Hsiu-Chiung Yang, Cathryn M. Kolka, Isaac Asare Bediako
Publikováno v:
Diabetes. 67
SGLT2 inhibition has positive effects on glucose balance, reducing fasting and postprandial glucose levels, however little is known about the effects of SGLT2 inhibitors on lipid levels. PKPD simulation for this canine model was applied for dose sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8218fadd351872f0977cb3aadd3959c2
https://doi.org/10.2337/db18-113-lb
https://doi.org/10.2337/db18-113-lb