Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Hsiou-Ting Kuo"'
Autor:
Lei Wang, Hsiou-Ting Kuo, Zhengxing Zhang, Chengcheng Zhang, Chao-Cheng Chen, Devon Chapple, Ryan Wilson, Nadine Colpo, François Bénard, Kuo-Shyan Lin
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Background Overexpressed in various solid tumors, gastrin-releasing peptide receptor (GRPR) is a promising cancer imaging marker and therapeutic target. Although antagonists are preferable for the development of GRPR-targeted radiopharmaceut
Externí odkaz:
https://doaj.org/article/24ff8b25475b4173968a9c483ac5e550
Autor:
Marin Simunic, Jay T. Joshi, Helen Merkens, Nadine Colpo, Hsiou-Ting Kuo, Julian J. Lum, François Bénard
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-7 (2024)
Externí odkaz:
https://doaj.org/article/d7a3c8e0d16a4df99867cf7dee5f8f2d
Autor:
Lei Wang, Hsiou-Ting Kuo, Chao-Cheng Chen, Devon Chapple, Nadine Colpo, Pauline Ng, Wing Sum Lau, Shireen Jozi, François Bénard, Kuo-Shyan Lin
Publikováno v:
Molecules, Vol 29, Iss 13, p 3102 (2024)
Gastrin-releasing peptide receptor (GRPR), overexpressed in many solid tumors, is a promising imaging marker and therapeutic target. Most reported GRPR-targeted radioligands contain a C-terminal amide. Based on the reported potent antagonist D-Phe-Gl
Externí odkaz:
https://doaj.org/article/90a3007f690d4f83bd84d2472d76249b
Autor:
Lei Wang, Chao-Cheng Chen, Zhengxing Zhang, Hsiou-Ting Kuo, Chengcheng Zhang, Nadine Colpo, Helen Merkens, François Bénard, Kuo-Shyan Lin
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 621 (2024)
Gastrin-releasing peptide receptor (GRPR) is overexpressed in various cancers and is a promising target for cancer diagnosis and therapy. However, the high pancreas uptake and/or metabolic instability observed for most reported GRPR-targeted radiolig
Externí odkaz:
https://doaj.org/article/16c02e200e2b477db4930b5913cbb995
Autor:
Kelly Lu, Chengcheng Zhang, Zhengxing Zhang, Hsiou-Ting Kuo, Nadine Colpo, François Bénard, Kuo-Shyan Lin
Publikováno v:
Molecules, Vol 28, Iss 13, p 5120 (2023)
Prostate-specific membrane antigen (PSMA) is a well-validated prostate cancer marker but reported PSMA-targeted tracers derived from the Lys-urea-Glu pharmacophore including the clinically validated [99mTc]Tc-EDDA/HYNIC-iPSMA have high off-target upt
Externí odkaz:
https://doaj.org/article/a23a92c7c4be45ef9200f20f8fc7bf64
Autor:
Shreya Bendre, Hsiou-Ting Kuo, Helen Merkens, Zhengxing Zhang, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 798 (2023)
Fibroblast activation protein (FAP) is a membrane-tethered serine protease overexpressed in the reactive stromal fibroblasts of >90% human carcinomas, which makes it a promising target for developing radiopharmaceuticals for the imaging and therapy o
Externí odkaz:
https://doaj.org/article/18c7ab88e11c4809acde95fb280becf0
Autor:
Arsyangela Verena, Hsiou-Ting Kuo, Helen Merkens, Jutta Zeisler, Shreya Bendre, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 449 (2023)
Compared to quinoline-based fibroblast activation protein (FAP)-targeted radiotracers, pyridine-based FAP-targeted tracers are expected to have faster pharmacokinetics due to their smaller molecular size and higher hydrophilicity, which we hypothesiz
Externí odkaz:
https://doaj.org/article/26ab9e7cafce478086200098b3ddc317
Autor:
Lei Wang, Ivica Jerolim Bratanovic, Zhengxing Zhang, Hsiou-Ting Kuo, Helen Merkens, Jutta Zeisler, Chengcheng Zhang, Ruiyan Tan, François Bénard, Kuo-Shyan Lin
Publikováno v:
Molecules, Vol 28, Iss 4, p 1977 (2023)
With overexpression in various cancers, the gastrin-releasing peptide receptor (GRPR) is a promising target for cancer imaging and therapy. However, the high pancreas uptake of reported GRPR-targeting radioligands limits their clinical application. O
Externí odkaz:
https://doaj.org/article/ef9da2d01f5147b6bd4f30e4a1398bab
Autor:
Arsyangela Verena, Zhengxing Zhang, Hsiou-Ting Kuo, Helen Merkens, Jutta Zeisler, Ryan Wilson, Shreya Bendre, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin
Publikováno v:
Molecules, Vol 28, Iss 3, p 1088 (2023)
Tumor heterogeneity limits the efficacy and reliability of monospecific radiopharmaceuticals in prostate cancer diagnosis and therapy. To overcome this limitation and improve lesion detection sensitivity, we developed and evaluated three bispecific r
Externí odkaz:
https://doaj.org/article/eb122ae3a6a84703bf06a1e06f36ea31
Autor:
Joseph Lau, Etienne Rousseau, Zhengxing Zhang, Carlos F. Uribe, Hsiou-Ting Kuo, Jutta Zeisler, Chengcheng Zhang, Daniel Kwon, Kuo-Shyan Lin, François Bénard
Publikováno v:
ACS Omega, Vol 4, Iss 1, Pp 1470-1478 (2019)
Externí odkaz:
https://doaj.org/article/b8f83b19019a4e37a92d4ada0626e53a