The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway

Autor: Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Yong-Cyuan Chen, Lin-Ping Lai, Wei-Fan Hsiao, Wen-Pin Chen, Yijuang Chern

Publikováno v: Journal of Biomedical Science, Vol 24, Iss 1, Pp 1-12 (2017)

Abstract Background The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except for its N-terminus (

Externí odkaz: https://doaj.org/article/eb06859d5bc34c888bd24cfbfe88efcf

A new drug design targeting the adenosinergic system for Huntington's disease.

Autor: Nai-Kuei Huang, Jung-Hsin Lin, Jiun-Tsai Lin, Chia-I Lin, Eric Minwei Liu, Chun-Jung Lin, Wan-Ping Chen, Yuh-Chiang Shen, Hui-Mei Chen, Jhih-Bin Chen, Hsing-Lin Lai, Chieh-Wen Yang, Ming-Chang Chiang, Yu-Shuo Wu, Chen Chang, Jiang-Fan Chen, Jim-Min Fang, Yun-Lian Lin, Yijuang Chern

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e20934 (2011)

BACKGROUND: Huntington's disease (HD) is a neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. The expanded CAG repeats are translated into polyglutamine (polyQ), causing aberrant functions as well as aggre

Externí odkaz: https://doaj.org/article/98dd3664ced9445b93d70d9ae3a8e2cd

GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons

Autor: Hung-Chih Kuo, Yijuang Chern, Ting Chien, Hsing-Lin Lai, Feng-Lan Chiu, Shu-Yung Chang, Yu-Ting Weng, De-Maw Chuang

Publikováno v: Molecular Psychiatry

Translin-associated protein X (TRAX) is a scaffold protein with various functions and has been associated with mental illnesses, including schizophrenia. We have previously demonstrated that TRAX interacts with a Gsα protein-coupled receptor, the A2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96655523439813717dd54736e4ac03fc
https://doi.org/10.1038/s41380-017-0007-z

Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

Autor: Hsing-Lin Lai, Jim-Min Fang, Ching-Pang Chang, Hui-Mei Chen, Sin-Jhong Cheng, David Blum, Yu-Han Kao, Luc Buée, Yijuang Chern, Emilie Faivre, Chun-Jung Lin, Yu-Ping Liao, Chia-Chia Lee

Publikováno v: Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2018, ⟨10.1007/s12035-018-1030-z⟩
Molecular Neurobiology, 2018, ⟨10.1007/s12035-018-1030-z⟩

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and synaptic dysfunction. Adenosine is an important homeostatic modulator that controls the bioenergetic network in the brain through regulating receptor-e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1465f4ac66169f1ac87ff4eb22ca20a2
https://www.hal.inserm.fr/inserm-01833298

Lack of type VI adenylyl cyclase (AC6) leads to abnormal sympathetic tone in neonatal mice

Autor: Chen Chang, Ching-Pang Chang, Yu-Shuo Wu, Meng-Syuan Lin, Chun-Kuei Su, Huei-Mei Chen, Yijuang Chern, Hsing-Lin Lai, Chen-Li Chien

Publikováno v: Experimental Neurology. 248:10-15

Visceral functions are regulated by a basal sympathetic nerve discharge (SND), also known as ‘sympathetic tone’. We demonstrate herein that AC6 existed in tyrosine hydroxylase-positive rostral ventrolateral medulla neurons in the brainstem. Adeny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a4cbda3b0636428247dfb71db142f7
https://doi.org/10.1016/j.expneurol.2013.05.015