Zobrazeno 1 - 10
of 512
pro vyhledávání: '"Hsing‐Jien Kung"'
Autor:
Rong-Hsuan Wang, Pin-Ru Chen, Yue-Ting Chen, Yi-Chang Chen, Yu-Hsin Chu, Chia-Chen Chien, Po-Chen Chien, Shao-Yun Lo, Zhong-Liang Wang, Min-Chen Tsou, Ssu-Yu Chen, Guang-Shen Chiu, Wen-Ling Chen, Yi-Hsuan Wu, Lily Hui-Ching Wang, Wen-Ching Wang, Shu-Yi Lin, Hsing-Jien Kung, Lu-Hai Wang, Hui-Chun Cheng, Kai-Ti Lin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Most cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation to aerobic glycolysis for energy production. By reducing enzyme activity of pyruvate kinase M2 (PKM2), cancer cells attain a greater fraction of glyco
Externí odkaz:
https://doaj.org/article/11ac430e3387400d8e564c205164f273
Autor:
Chieh Huo, Ying‐Yu Kuo, Ching‐Yu Lin, Shine‐Gwo Shiah, Chia‐Yang Li, Shu‐Pin Huang, Jen‐Kun Chen, Wen‐Ching Wang, Hsing‐Jien Kung, Chih‐Pin Chuu
Publikováno v:
Cancer Medicine, Vol 13, Iss 16, Pp n/a-n/a (2024)
Abstract Background Prostate cancer (PCa) patients with elevated level of androgen receptor (AR) correlate with higher metastatic incidence. Protein expression of AR and its target gene prostate‐specific antigen (PSA) are elevated in metastatic pro
Externí odkaz:
https://doaj.org/article/39ea7ea40a3a452fa6a80b7de7df3a9c
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-23 (2023)
Abstract Background Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as an antioxidant. Howe
Externí odkaz:
https://doaj.org/article/b3625fd624e844c7a278293d9e6e7fdb
Autor:
Jai-Shin Liu, Wei-Kai Fang, Shan-Min Yang, Meng-Chen Wu, Tsan-Jan Chen, Chih-Ming Chen, Tung-Yueh Lin, Kai-Lun Liu, Chien-Ming Wu, Yun-Ching Chen, Chih-Pin Chuu, Ling-Yu Wang, Hsing-Pang Hsieh, Hsing-Jien Kung, Wen-Ching Wang
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-13 (2022)
Abstract Background Castration-resistant prostate cancer (CRPC) with sustained androgen receptor (AR) signaling remains a critical clinical challenge, despite androgen depletion therapy. The Jumonji C-containing histone lysine demethylase family 4 (K
Externí odkaz:
https://doaj.org/article/e6fc84a951a64927b29a0a1dd04a7072
Autor:
Yi-Chang Wang, Andrew A. Kelso, Adak Karamafrooz, Yi-Hsuan Chen, Wei-Kai Chen, Chun-Ting Cheng, Yue Qi, Long Gu, Linda Malkas, Angelo Taglialatela, Hsing-Jien Kung, George-Lucian Moldovan, Alberto Ciccia, Jeremy M. Stark, David K. Ann
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112296- (2023)
Summary: The arginine dependency of cancer cells creates metabolic vulnerability. In this study, we examine the impact of arginine availability on DNA replication and genotoxicity resistance. Using DNA combing assays, we find that limiting extracellu
Externí odkaz:
https://doaj.org/article/02cf18b55c154e37b1ee31164012f9d4
Autor:
Chiu-Lien Hung, Hao-Hsuan Liu, Chih-Wei Fu, Hsun-Hao Yeh, Tsan-Lin Hu, Zong-Keng Kuo, Yu-Chin Lin, Mei-Ru Jhang, Chrong-Shiong Hwang, Hung-Chih Hsu, Hsing-Jien Kung, Ling-Yu Wang
Publikováno v:
EBioMedicine, Vol 90, Iss , Pp 104500- (2023)
Summary: Background: Despite the advent of improved therapeutic options for advanced prostate cancer, the durability of clinical benefits is limited due to inevitable development of resistance. By constitutively sustaining androgen receptor (AR) sign
Externí odkaz:
https://doaj.org/article/261dfea0757d4c98a4f29cb07cc5898e
Autor:
Hong Wang, Qianqian Wang, Guodi Cai, Zhijian Duan, Zoann Nugent, Jie Huang, Jianwei Zheng, Alexander D. Borowsky, Jian Jian Li, Peiqing Liu, Hsing-Jien Kung, Leigh Murphy, Hong-Wu Chen, Junjian Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1871-1884 (2022)
Metabolic and epigenetic reprogramming play important roles in cancer therapeutic resistance. However, their interplays are poorly understood. We report here that elevated TIGAR (TP53-induced glycolysis and apoptosis regulator), an antioxidant and gl
Externí odkaz:
https://doaj.org/article/538925d98d464283b8a69c88387e94f7
Autor:
Nian Jiang, Bowen Xie, Wenwu Xiao, Ming Fan, Shanxiu Xu, Yixin Duan, Yamah Hamsafar, Angela C. Evans, Jie Huang, Weibing Zhou, Xuelei Lin, Ningrong Ye, Siyi Wanggou, Wen Chen, Di Jing, Ruben C. Fragoso, Brittany N. Dugger, Paul F. Wilson, Matthew A. Coleman, Shuli Xia, Xuejun Li, Lun-Quan Sun, Arta M. Monjazeb, Aijun Wang, William J. Murphy, Hsing-Jien Kung, Kit S. Lam, Hong-Wu Chen, Jian Jian Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Acquired radioresistance is a challenge for the cure of glioblastoma. Here, the authors show that radioresistant glioblastoma boosts mitochondrial fatty acid oxidation that fuels cell proliferation and induces immunosuppression via CD47 mediated anti
Externí odkaz:
https://doaj.org/article/9ea4ad505be945a8af46118fb26c43d3
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in Metazoa that controls organ size through regulating cell proliferation and
Externí odkaz:
https://doaj.org/article/21eadfce02d44faba347ce9052984e6d
Autor:
Chia-Lin Chen, Sheng-Chieh Hsu, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K. Ann, Yun Yen, Hsing-Jien Kung
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Alterations in metabolism and amino acid usage are common in cancer cells. Here, the authors show in prostate cancer cells that arginine globally upregulates nuclear-encoded oxidative phosphorylation genes by altering histone acetylation and retainin
Externí odkaz:
https://doaj.org/article/d64749011def4c1eae0aaa79e53f01e3