Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hsin-I Jen"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract GFI1 is a zinc finger transcription factor that is necessary for the differentiation and survival of hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of hundreds of hair cell genes: this is a surprisin
Externí odkaz:
https://doaj.org/article/3b245ce5a0af4541b0ad27a030592191
Autor:
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M McGovern, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J Sun, Russell S Ray, Yehoash Raphael, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 11 (2022)
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression in the developing cochlea can efficiently induce hair cell regeneration
Externí odkaz:
https://doaj.org/article/4cbcd933e07d46508ec37fe3ede0949c
Autor:
Sungsu Lee, Jae-Jun Song, Lisa A. Beyer, Donald L. Swiderski, Diane M. Prieskorn, Melih Acar, Hsin-I Jen, Andrew K. Groves, Yehoash Raphael
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost, leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals have used over-expression of the HC-specific transcription facto
Externí odkaz:
https://doaj.org/article/a5f302ca620148b1ae8d55867529301b
Autor:
Hsin-I Jen, Matthew C Hill, Litao Tao, Kuanwei Sheng, Wenjian Cao, Hongyuan Zhang, Haoze V Yu, Juan Llamas, Chenghang Zong, James F Martin, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 8 (2019)
The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of hearing. In contrast, the adult vestibular system can produce new hair cells in response to damage, or by reprogramming of supporting cells with the hair cell
Externí odkaz:
https://doaj.org/article/627c72e39e6e4cba80400a301229c433
Autor:
Martin L Basch, Rogers M Brown II, Hsin-I Jen, Fatih Semerci, Frederic Depreux, Renée K Edlund, Hongyuan Zhang, Christine R Norton, Thomas Gridley, Susan E Cole, Angelika Doetzlhofer, Mirjana Maletic-Savatic, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 5 (2016)
The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti. Cre-Lox fate
Externí odkaz:
https://doaj.org/article/ef349eec4d0042e7ac246fa6ab85e782
Autor:
Juan C Maass, Rende Gu, Tiantian Cai, Ying-Wooi Wan, Silvia C Cantellano, Joanna S T Asprer, Hongyuan Zhang, Hsin-I Jen, Renée K Edlund, Zhandong Liu, Andrew K Groves
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167286 (2016)
Neonatal mouse cochlear supporting cells have a limited ability to divide and trans-differentiate into hair cells, but this ability declines rapidly in the two weeks after birth. This decline is concomitant with the morphological and functional matur
Externí odkaz:
https://doaj.org/article/ba681abddecc40ff923e417a0fa3bc6f
Autor:
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M McGovern, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J Sun, Russell S Ray, Yehoash Raphael, Neil Segil, Andrew K Groves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb899682977eaa33a98d9bf44af4bb7
https://doi.org/10.7554/elife.79712.sa2
https://doi.org/10.7554/elife.79712.sa2
Autor:
Amrita A. Iyer, Ishwar Hosamani, John D. Nguyen, Tiantian Cai, Sunita Singh, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J. Sun, Russell S. Ray, Yehoash Raphael, Neil Segil, Andrew K. Groves
Reprogramming of the cochlea with hair cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression in the developing cochlea can efficiently induce hair cell regeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d1b8d027dd848714d011bbf01c6548a
https://doi.org/10.1101/2022.05.03.490440
https://doi.org/10.1101/2022.05.03.490440
Publikováno v:
Scientific reports. 12(1)
GFI1 is a zinc finger transcription factor that is necessary for the differentiation and survival of hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of hundreds of hair cell genes: this is a surprising result,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9a20b2934e97faa6c6a4b5057ea2f9
https://pubmed.ncbi.nlm.nih.gov/35551236
https://pubmed.ncbi.nlm.nih.gov/35551236
Autor:
Hsin-I Jen, Donald L. Swiderski, Lisa A. Beyer, Jae-Jun Song, Yehoash Raphael, Melih Acar, Sungsu Lee, Andrew K. Groves, Diane M. Prieskorn
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost, leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals have used over-expression of the HC-specific transcription factor Atoh1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a82e56884f10c70f99dbd66d3c067ce
https://doi.org/10.1038/s41598-020-78167-8
https://doi.org/10.1038/s41598-020-78167-8