Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hsin-Hui Shu"'
Autor:
Thuy-Anh Tran, Bryan Kramer, Young-Jun Shin, Quyen-Quyen Do, Brett Ullman, Vasudeva Sagi, John W. Adams, Yunqing Shi, Hsin-Hui Shu, David J. Unett, Joel Gatlin, Michael E. Morgan, Jaimie Reuter, Anthony Blackburn, Carleton R. Sage, Graeme Semple
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100518- (2022)
The design of a new series of β3-Adrenergic receptor (β3-AdrR) antagonists is described. The use of a spiro building block in the core of the molecule provided novel compounds with reduced aromaticity and antagonist activity at the human β3-AdrR.
Externí odkaz:
https://doaj.org/article/6533cc49f4b54ba9916eb28cfabb9af8
Autor:
Hsin-Hui Shu, 舒馨慧
94
Rat brain type IIA Na+ channel is a member of the voltage-gated Na+ channel which is composed of four structurally similar domains (I-IV). Each of the domain has six transmembrane segments (S1-S6). Because S4 contains regularly spaced basic a
Rat brain type IIA Na+ channel is a member of the voltage-gated Na+ channel which is composed of four structurally similar domains (I-IV). Each of the domain has six transmembrane segments (S1-S6). Because S4 contains regularly spaced basic a
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/37482853346955329479
Autor:
Khawja A. Usmani, Dawei Yue, Zhi-Liang Chu, Abu J.M. Sadeque, Chris Carroll, Chuan Chen, Hsin-Hui Shu, Sanju Narayanan, Hussein Al-Sharmma, Dominic P. Behan, Robert M. Jones, Graeme Semple, James N. Leonard, David J. Unett, Daniel J. Buzard, Michael Morgan, Juerg Lehmann, Imelda Calderon, Shiu-Feng Tung, Woo Hyun Yoon, Xiuwen Zhu, Sangdon Han, Andrew M. Kawasaki, Amy Siu-Ting Wong, Sun Hee Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3034-3038
The design and optimization of a novel trans-1,4-dioxycyclohexane GPR119 agonist series is described. A lead compound 21 was found to be a potent and efficacious GPR119 agonist across species, and possessed overall favorable pharmaceutical properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f3b9e4db6f1603a99df66761f2f277
https://doi.org/10.1016/j.bmcl.2015.04.102
https://doi.org/10.1016/j.bmcl.2015.04.102
Autor:
Antonio Garrido Montalban, Steve Chang, Shakya Sagar, P. Douglas Boatman, Weichao Chen, Dominic P. Behan, Thuy-Anh Tran, Yunqing Shi, Young-Jun Shin, Krishnan Ashwin M, Pureza Vallar, John W. Adams, David J. Unett, Michael Morgan, Bryan A. Kramer, Biman B. Pal, Hsin-Hui Shu, Anthony C. Blackburn, Juan Ramirez, Shiu-Feng Tung, Xiaohua Chen, Tina Leakakos, Ning Zou, Abu J.M. Sadeque, Tawfik Gharbaoui, Carleton R. Sage, Anna Shifrina, Graeme Semple, Ibragim Gaidarov
Publikováno v:
Journal of medicinal chemistry. 60(3)
The design and synthesis of a new series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model of pulmonary arterial hypertension (PAH) are described. Detailed profiling of a number of analogues result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3808129dea9a6540d0ac87cf636e0752
https://pubmed.ncbi.nlm.nih.gov/28072531
https://pubmed.ncbi.nlm.nih.gov/28072531
Autor:
Young-Jun Shin, Hsin-Hui Shu, P. Douglas Boatman, Juyi Choi, Steve Chang, Michael Morgan, Graeme Semple, Peter Martens, John W. Adams, Ning Zou, David J. Unett, Yunqing Shi, Shiu-Feng Tung, Pureza Vallar, Bryan A. Kramer, Thuy-Anh Tran, Juan Ramirez
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(5)
The design and synthesis of two closely related series of prostacyclin receptor agonist compounds that showed excellent human IP receptor potency and efficacy is described. Compounds from this series showed in vivo activity after SC dosing in the mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f18b1b98bf673d82965b415adc56a6
https://pubmed.ncbi.nlm.nih.gov/25666818
https://pubmed.ncbi.nlm.nih.gov/25666818
Autor:
Luis Lopez, Daniel J. Buzard, Abu J.M. Sadeque, David J. Unett, Ching-Fen Chuang, Hsin-Hui Shu, Rohit Bhat, James N. Leonard, Sanju Narayanan, Dawei Yue, Robert M. Jones, Amy Siu-Ting Wong, Michael Morgan, Zhi-Liang Chu, Juerg Lehmann, Sun Hee Kim, Hussien A. Al-Shamma, Imelda Calderon, Kevin Whelan, Steve Chang, Shiu-Feng Tung, Tawfik Gharbaoui, Andrew M. Kawasaki, Sangdon Han
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(17)
A series of 5-fluoro-4,6-dialkoxypyrimidine GPR119 modulators were discovered and optimized for in vitro agonist activity. A lead molecule was identified that has improved agonist efficacy relative to our clinical compound (APD597) and possesses redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad2ab4757cddc23a6a0ea787351b612
https://pubmed.ncbi.nlm.nih.gov/25088191
https://pubmed.ncbi.nlm.nih.gov/25088191
Autor:
Hsin-Hui, Shu
Thesis (M.A.)--National Taiwan University Graduate Institute of Physiology
Non-Latin script record. Includes bibliographical references
Non-Latin script record. Includes bibliographical references