Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor.

Autor: Anthony R Dallosso, Anne L Hancock, Marianna Szemes, Kim Moorwood, Laxmi Chilukamarri, Hsin-Hao Tsai, Abby Sarkar, Jonathan Barasch, Raisa Vuononvirta, Chris Jones, Kathy Pritchard-Jones, Brigitte Royer-Pokora, Sean Bong Lee, Ceris Owen, Sally Malik, Yi Feng, Marcus Frank, Andrew Ward, Keith W Brown, Karim Malik

Publikováno v: PLoS Genetics, Vol 5, Iss 11, p e1000745 (2009)

Wilms' tumour (WT) is a pediatric tumor of the kidney that arises via failure of the fetal developmental program. The absence of identifiable mutations in the majority of WTs suggests the frequent involvement of epigenetic aberrations in WT. We there

Externí odkaz: https://doaj.org/article/7af8fa26a11e4c70987e9295678bdc7f

Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor

Autor: Keith W. Brown, Karim Malik, Yi Feng, Marianna Szemes, Hsin-Hao Tsai, Jonathan Barasch, Anthony R. Dallosso, Andrew Ward, Laxmi Chilukamarri, Ceris Owen, Kathy Pritchard-Jones, Anne L. Hancock, Brigitte Royer-Pokora, Raisa Vuononvirta, Kim Moorwood, Sean Bong Lee, Abby Sarkar, Chris Jones, Marcus Frank, Sally Malik

Publikováno v: Dallosso, A R, Hancock, A L, Szemes, M, Moorwood, K, Chilukamarri, L, Tsai, H-H, Sarkar, A, Barasch, J, Vuononvirta, R, Jones, C, Pritchard-Jones, K, Royer-Pokora, B, Lee, S B, Owen, C, Malik, S, Feng, Y, Frank, M, Ward, A, Brown, K W & Malik, K 2009, ' Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor ', PLoS Genetics, vol. 5, no. 11, e1000745 . https://doi.org/10.1371/journal.pgen.1000745
PLOS GENET, 5 (11), Article e1000745. (2009)
PLoS Genetics
Dallosso, A R, Hancock, A L, Szemes, M, Moorwood, K, Chilukamarri, L, Tsai, H H, Sarkar, A, Barasch, J, Vuononvirta, R, Jones, C, Pritchard-Jones, K, Royer-Pokora, B, Lee, S B, Owen, C, Malik, S, Feng, Y, Frank, M, Ward, A, Brown, K W & Malik, K 2009, ' Frequent long-range epigenetic silencing of Protocadherin gene clusters on chromosome 5q31 in Wilms' Tumor ', Plos Genetics, vol. 5, no. 11, e1000745 . https://doi.org/10.1371/journal.pgen.1000745
PLoS Genetics, Vol 5, Iss 11, p e1000745 (2009)

Wilms' tumour (WT) is a pediatric tumor of the kidney that arises via failure of the fetal developmental program. The absence of identifiable mutations in the majority of WTs suggests the frequent involvement of epigenetic aberrations in WT. We there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012c60532b00d73f79f85e1a94f89b74
https://www.pure.ed.ac.uk/ws/files/8144707/Frequent_long_range_epigenetic_silencing_of_protocadherin_gene_clusters_on_chromosome_5q31_in_Wilms_tumor.pdf

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)

Autor: Victoria Valinluck, Lawrence C. Sowers, Artur Burdzy, Hsin-Hao Tsai, Daniel K. Rogstad, Adrian Bird

Cytosine methylation in CpG dinucleotides is believed to be important in gene regulation, and is generally associated with reduced levels of transcription. Methylation-mediated gene silencing involves a series of DNA-protein and protein-protein inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5c9cfe77f0f935eba6140c997da257
https://europepmc.org/articles/PMC514367/

Mbd2 Contributes to DNA Methylation-Directed Repression of the Xist Gene.

Autor: Barr, Helen, Hermann, Andrea, Berger, Jennifer, Hsin-Hao Tsai, Adie, Karen, Prokhortchouk, Anna, Hendrich, Brian, Bird, Adrian

Publikováno v: Molecular & Cellular Biology; May2007, Vol. 27 Issue 10, p16-16, 1p