Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hsin Pin Ho Liang"'
Autor:
Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi, Riju Shrestha, Karishma Maharaja, Paridhi Sukheja, Shao-Gang Li, Daigo Inoyama, Matthew Zimmerman, Hsin Pin Ho Liang, Jansy Sarathy, Marizel Mina, George Rasic, Riccardo Russo, Alexander L. Perryman, Todd Richmann, Aditi Gupta, Eric Singleton, Sheetal Verma, Seema Husain, Patricia Soteropoulos, Zhe Wang, Roxanne Morris, Gene Porter, Gautam Agnihotri, Padmini Salgame, Sean Ekins, Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. Genetic and biochemical studies established KasA as the primary target. The X-ray crystal structure of the KasA-DG167 compl
Externí odkaz:
https://doaj.org/article/8d6c465583e4410c8afdd48c4a9a3287
Autor:
Valentina Guerrini, Brendan Prideaux, Landry Blanc, Natalie Bruiners, Riccardo Arrigucci, Sukhwinder Singh, Hsin Pin Ho-Liang, Hugh Salamon, Pei-Yu Chen, Karim Lakehal, Selvakumar Subbian, Paul O'Brien, Laura E Via, Clifton E Barry, Véronique Dartois, Maria Laura Gennaro
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007223 (2018)
Foam cells are lipid-laden macrophages that contribute to the inflammation and tissue damage associated with many chronic inflammatory disorders. Although foam cell biogenesis has been extensively studied in atherosclerosis, how these cells form duri
Externí odkaz:
https://doaj.org/article/3747bcd88e6540c69d80b16441707b17
Autor:
Frank J. Schoenen, Ben Gold, Véronique Dartois, David T Zhang, Carl Nathan, Patrick Porubsky, Stacey L. McDonald, Matthew D. Zimmerman, Quyen Nguyen, Hsin-Pin Ho-Liang, Andrew J. Perkowski, Cameron W Pharr, Robert A. Smith, Jeffrey Aubé
Publikováno v:
The Journal of antibiotics
A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.
Autor:
Xin Wang, Liping Li, Paridhi Sukheja, David Alland, Kholiswa Tsotetsi, Hsin Pin Ho Liang, David S. Perlin, Véronique Dartois, Todd Richmann, Courtney Grady, Glenn C. Capodagli, Matthew B. Neiditch, Riju Shrestha, Pradeep Kumar, Nancy D. Connell, Joel S. Freundlich, Ravindra Jadhav, Matthew D. Zimmerman, Marizel Mina, Steven Park, Riccardo Russo, Shao-Gang Li, Yong Mo Ahn, Daigo Inoyama, Divya Awasthi
Publikováno v:
Cell Chem Biol
Summary Published Mycobacterium tuberculosis β-ketoacyl-ACP synthase KasA inhibitors lack sufficient potency and/or pharmacokinetic properties. A structure-based approach was used to optimize existing KasA inhibitor DG167. This afforded indazole JSF
Autor:
Hsin Pin Ho Liang, Shuyi Ma, Hassan Safi, David R. Sherman, Liping Li, Patricia Soteropoulos, David Alland, Véronique Dartois, Subramanya Lingaraju, Pooja Gopal, Landry Blanc, Seema Husain, Michelle Yee, Thomas Dick, Mainul Hoque, Carly Levine, Tige R. Rustad
Publikováno v:
Proc Natl Acad Sci U S A
The length and complexity of tuberculosis (TB) therapy, as well as the propensity ofMycobacterium tuberculosisto develop drug resistance, are major barriers to global TB control efforts.M. tuberculosisis known to have the ability to enter into a drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29dfe8a9487b6469c04e1e51b2ac6c0b
https://doi.org/10.1101/717272
https://doi.org/10.1101/717272
Autor:
Selin Somersan Karakaya, Landys Lopez Quezada, Kohta Saito, Cameron W Pharr, Sara Palomo Dı Az, Kelin Li, Quyen Nguyen, Hsin-Pin Ho Liang, Julia Roberts, Prisca Elis Javidnia, Manuel Marin Amieva, Véronique Dartois, Carl Nathan, Ben Gold, Stéphanie Sans, Matthew D. Zimmerman, Laurent Goullieux, Jeffrey Aubé, Alfonso Mendoza Losana, Esther Porras de Francisco, Christine Roubert, Andrew J. Perkowski, Kathrine McAulay, Stacey L. McDonald, Jun Zhang, Sophie Lagrange
Publikováno v:
ACS Infect Dis
The historical view of β-lactams as ineffective antimycobacterials has given way to growing interest in the activity of this class against Mycobacterium tuberculosis (Mtb) in the presence of a β-lactamase inhibitor. However, most antimycobacterial
Autor:
Hsin-Pin Ho Liang, Padmini Salgame, Brendan Prideaux, Firat Kaya, Jansy Sarathy, Marizel Mina, Jillian Dietzold, Denise E. Kirschner, Nadine Alvarez-Cabrera, Véronique Dartois, Landry Blanc, Paul O'Brien, Radojka M. Savic, Elsje Pienaar, Isabela Dias-Freedman, Matthew D. Zimmerman, Jennifer J. Linderman
Publikováno v:
Antimicrobial agents and chemotherapy, vol 63, iss 5
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patients. Recently, several clinical trials of “universal” drug regimens, ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c4796489044a91794000c22f649cf4
https://escholarship.org/uc/item/4qr8t1h1
https://escholarship.org/uc/item/4qr8t1h1
Autor:
Riju Shrestha, Matthew D. Zimmerman, Karishma Maharaja, Padmini Salgame, Divya Awasthi, Joel S. Freundlich, Glenn C. Capodagli, Aditi Gupta, David Alland, Hsin Pin Ho Liang, Alexander L. Perryman, Gene Porter, Riccardo Russo, Gautam Agnihotri, Roxanne Morris, Véronique Dartois, Marizel Mina, Sean Ekins, Sheetal Verma, Daigo Inoyama, Kyu Y. Rhee, Paridhi Sukheja, Patricia Soteropoulos, George Rasic, Jansy Sarathy, Todd Richmann, Zhe Wang, Nancy D. Connell, Eric Singleton, Matthew B. Neiditch, Seema Husain, Pradeep Kumar, Shao-Gang Li
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e02101-17 (2018)
mBio
mBio, Vol 9, Iss 6, p e02101-17 (2018)
mBio
Cell wall biosynthesis inhibitors have proven highly effective for treating tuberculosis (TB). We discovered and validated members of the indazole sulfonamide class of small molecules as inhibitors of Mycobacterium tuberculosis KasA—a key component
Autor:
Jansy P, Sarathy, Hsin-Pin Ho, Liang, Danielle, Weiner, Jacqueline, Gonzales, Laura E, Via, Véronique, Dartois
Publikováno v:
Journal of visualized experiments : JoVE. (123)
The eradication of tuberculosis disease requires drug regimens that can penetrate the multiple layers of complex pulmonary lesions. Drug distribution in the caseous cores of cavities and lesions is especially crucial because they harbor subpopulation
Autor:
Julia Roberts, Stacey L. McDonald, Stéphanie Sans, Landys Lopez Quezada, Kelin Li, Prisca Elis Javidnia, Hsin-pin Ho Liang, Carl Nathan, Cameron W Pharr, Sara Palomo, Kathrine McAulay, Laurent Goullieux, Jun Zhang, Véronique Dartois, Jeffrey Aubé, Matthew C. Zimmerman, Alfonso Mendoza Losana, Kohta Saito, Ben Gold, Sophie Lagrange, Quyen Nguyen, Selin Somersan Karakaya, Manuel Marin Amieva, Esther Porras de Francisco, Christine Roubert, Andrew J. Perkowski
Publikováno v:
ACS Infectious Diseases. 5:2175-2175