Výsledky vyhledávání - "Hsieng Sen Lu"

Discovery of the Migraine Prevention Therapeutic Aimovig (Erenumab), the First FDA-Approved Antibody against a G-Protein-Coupled Receptor

Autor: Brian Mingtung Chan, Kelly A Berry, David W. Brankow, Chadwick T. King, Sylvia Nai-Yu Hu, Nebojsa Kezunovic, Tom Boone, Licheng Shi, Cen Xu, Colin V. Gegg, Matt R. Kelley, Hsieng Sen Lu

Publikováno v: ACS Pharmacol Transl Sci

[Image: see text] In 2018, the United States Food and Drug Administration (FDA) approved Aimovig (erenumab) for the prevention of migraine. Erenumab is the first FDA approved antibody therapeutic against a G-protein-coupled receptor, the canonical re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a97f4f56650c1bbf83553db82caa76
https://doi.org/10.1021/acsptsci.9b00061

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Recombinant human lecithin-cholesterol acyltransferase Fc fusion: Analysis of N- and O-linked glycans and identification and elimination of a xylose-based O-linked tetrasaccharide core in the linker region

Autor: Richard Zhang, Zhen Xia, Justin Kim, Hsieng Sen Lu, Jennitte Stevens, Mingyue Zhou, Paul Kodama, Jay Tang, Sophia Siu, Chris Spahr, Sihong Deng, Noi Nuanmanee, Bram Estes

Publikováno v: Protein Science. 22:1739-1753

Recombinant human lecithin-cholesterol acyltransferase Fc fusion (huLCAT-Fc) is a chimeric protein produced by fusing human Fc to the C-terminus of the human enzyme via a linker sequence. The huLCAT-Fc homodimer contains five N-linked glycosylation s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ee29fd84a9456a29f2701f4d003596f
https://doi.org/10.1002/pro.2373

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Human Dickkopf-1 (huDKK1) protein: Characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains

Autor: Chris Spahr, Hsieng Sen Lu, William G. Richards, Ching Chen, Mitsuru Haniu, Wei Fan, Tom Horan, John O. Hui

Publikováno v: Protein Science. 20:1802-1813

Human Dickkopf-1 (huDKK1), an inhibitor of the canonical Wnt-signaling pathway that has been implicated in bone metabolism and other diseases, was expressed in engineered Chinese hamster ovary cells and purified. HuDKK1 is biologically active in a TC

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https://doi.org/10.1002/pro.705

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Ligand-Binding Mass Spectrometry to Study Biotransformation of Fusion Protein Drugs and Guide Immunoassay Development: Strategic Approach and Application to Peptibodies Targeting the Thrombopoietin Receptor

Autor: Michael Hall, Hsieng Sen Lu, Christopher S. Spahr, Robert Ortiz, Steven Yu, Colin V. Gegg, Kenneth W. Walker, Jean W. Lee, Vimal Patel, Liana Zhang, Binodh DeSilva

Publikováno v: The AAPS Journal. 12:576-585

The knowledge of in vivo biotransformation (e.g., proteolysis) of protein therapeutic candidates reveals structural liabilities that impact stability. This information aids the development and confirmation of ligand-binding assays with the required s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180ca94a2bdcef05a7dfaace19bdf26c
https://doi.org/10.1208/s12248-010-9218-9

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Structure of the active core of human stem cell factor and analysis of binding to its receptor Kit

Autor: Ogan Gurel, Rashid Syed, Wayne A. Hendrickson, Hsieng Sen Lu, Xuliang Jiang, Elizabeth A. Mendiaz, Osslund Timothy D, Keith Langley, Christi L. Clogston, George Stearns

Publikováno v: The EMBO Journal. 19:3192-3203

Stem cell factor (SCF) is an early-acting hematopoietic cytokine that elicits multiple biological effects. SCF is dimeric and occurs in soluble and membrane-bound forms. It transduces signals by ligand- mediated dimerization of its receptor, Kit, whi

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https://doi.org/10.1093/emboj/19.13.3192

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Peptide map procedure using immobilized protease cartridges in tandem for disulfide linkage identification of neu differentiation factor epidermal growth factor domain

Autor: Viswanatham Katta, Shinichi Hara, Hsieng Sen Lu

Publikováno v: Journal of Chromatography A. 867:151-160

Immobilized proteolytic enzyme cartridges were used to rapidly digest neu differentiation factor EGF domain in order to obtain improved peptide maps useful for assignment of disulfide linkages. The procedure described here involves an on-line digesti

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https://doi.org/10.1016/s0021-9673(99)01110-3

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Heparin Is Essential for a Single Keratinocyte Growth Factor Molecule To Bind and Form a Complex with Two Molecules of the Extracellular Domain of Its Receptor

Autor: Christopher S. Spahr, Rebecca Nybo, Morris Charles F, John S. Philo, Caroline Wong, Robert E. Pacifici, Victoria J. Costigan, Jill Crouse, Michael D. Jones, Yueh-Rong Hsu, Hsieng Sen Lu, John K. Sullivan, Andrea G. Pentzer

Publikováno v: Biochemistry. 38:2523-2534

Keratinocyte growth factor (KGF or FGF-7) is a member of the heparin binding fibroblast growth factor (FGF) family and is a paracrine mediator of proliferation and differentiation of a wide variety of epithelial cells. To examine the stoichiometry of

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https://doi.org/10.1021/bi9821317

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Identification of a lipoxygenase inhibitor in A431 cells as a phospholipid hydroperoxide glutathione peroxidase

Autor: Hei Sheng Huang, Ching Jiunn Chen, Hsieng Sen Lu, Wen Chang Chang

Publikováno v: FEBS Letters. 424:22-26

An endogenous lipoxygenase inhibitor, purified from the cytosol of human epidermoid carcinoma A431 cells, was analyzed by N-terminal microsequencing and mass spectrometric analysis. The inhibitor was purified by SDS-PAGE, then subjected to in-gel CNB

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https://doi.org/10.1016/s0014-5793(98)00130-6

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