Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hsien-Tsung Lai"'
Autor:
Hsien-Tsung Lai, Cheng- Chiang
Publikováno v:
Bio-Protocol, Vol 3, Iss 20 (2013)
Bimolecular Fluorescence Complementation (BiFC) assay is a method used to directly visualize protein-protein interaction in vivo using live-cell imaging or fixed cells. This protocol described here is based on our recent paper describing the function
Externí odkaz:
https://doaj.org/article/a86d3658401d4d9aac223f688c09432c
Autor:
Zhiqing Liu, Yi Li, Haiying Chen, Hsien-Tsung Lai, Pingyuan Wang, Shwu-Yuan Wu, Eric A. Wold, Paul G. Leonard, Sarah Joseph, Haitao Hu, Cheng-Ming Chiang, Allan R. Brasier, Bing Tian, Jia Zhou
Publikováno v:
J Med Chem
Bromodomain-containing protein 4 (BRD4) is an emerging epigenetic drug target for intractable inflammatory disorders. The lack of highly selective inhibitors among BRD4 family members has stalled the collective understanding of this critical system a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c045f0d6c993fde71c5af9e8db998b5
https://pubmed.ncbi.nlm.nih.gov/34982556
https://pubmed.ncbi.nlm.nih.gov/34982556
Autor:
Hsien Tsung Lai, Miles R. Fontenot, Yan Chen, Jack M Raisanen, Jennifer E. Wang, Bradley C. Lega, Shwu Yuan Wu, Lei Bao, Gregg L. Semenza, Weibo Luo, Yingfei Wang, Cheng Ming Chiang, Kimmo J. Hatanpaa
Publikováno v:
Nucleic Acids Research
Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator in response to hypoxia and its transcriptional activity is crucial for cancer cell mobility. Here we present evidence for a novel epigenetic mechanism that regulates HIF-1 trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2674274987698b8a30a1a278fb4e5468
http://europepmc.org/articles/PMC6061882
http://europepmc.org/articles/PMC6061882
Autor:
Hsien Tsung Lai, Kai Ge, Hao Zuo, Cheng Tai Yu, Ming-Jer Tsai, Ji-Eun Lee, Chien Fei Lee, Yihong Wan, Shwu Yuan Wu, Cheng Ming Chiang, Sophia Y. Tsai
Publikováno v:
Mol Cell
Bromodomain-containing protein 4 (BRD4) is a cancer therapeutic target in ongoing clinical trials disrupting primarily BRD4-regulated transcription programs. The role of BRD4 in cancer has been attributed mainly to the abundant long isoform (BRD4-L).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c665010b3f38438f097f2fa11644b6
https://pubmed.ncbi.nlm.nih.gov/32559427
https://pubmed.ncbi.nlm.nih.gov/32559427
Autor:
Yingfei Wang, Lei Bao, Cheng Ming Chiang, Hsien-Tsung Lai, Gregg L. Semenza, Weibo Luo, Yan Chen
Publikováno v:
Cancer Research. 78:5427-5427
Hypoxia-inducible factor 1 (HIF-1) is a main regulator of cellular response to hypoxia and its transcriptional activity is crucial for cancer cell migration and invasion. Post-translational modifications of the α subunit of HIF-1 (HIF-1α) play domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fb7db7de64b3770935d29912515c910
https://doi.org/10.1158/1538-7445.am2018-5427
https://doi.org/10.1158/1538-7445.am2018-5427
Autor:
Deodato Magante, Mun Kyoung Kim, Yoon Soon Kang, Hsien-Tsung Lai, William E. Stumph, Nermeen H. Barakat
Publikováno v:
Molecular and Cellular Biology. 30:2411-2423
The small nuclear RNA (snRNA)-activating protein complex (SNAPc) is essential for transcription of genes coding for the snRNAs (U1, U2, etc.). In Drosophila melanogaster, the heterotrimeric DmSNAPc recognizes a 21-bp DNA sequence, the proximal sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a3a26251804835fe1d4044aea694de
https://doi.org/10.1128/mcb.01508-09
https://doi.org/10.1128/mcb.01508-09
Publikováno v:
Toxicology and Applied Pharmacology. 144:171-176
The cogenotoxicity of Cd has been recognized. This effect may stem from Cd inhibition of DNA repair. We studied the effects of Cd on DNA repair of methyl methanesulfonate (MMS)-damaged Chinese hamster ovary cells (CHO-K1) by single-cell alkaline elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2c0b39c9ce0da390f37d3715660de9
https://doi.org/10.1006/taap.1997.8116
https://doi.org/10.1006/taap.1997.8116
Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting
Bromodomain-containing protein 4 (Brd4) is an epigenetic reader and transcriptional regulator recently identified as a cancer therapeutic target for acute myeloid leukemia, multiple myeloma, and Burkitt's lymphoma. Although chromatin targeting is a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e32d3d1501bb0e7f2a7d345b36918fa
https://europepmc.org/articles/PMC3595396/
https://europepmc.org/articles/PMC3595396/
Publikováno v:
The FASEB Journal. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91889cbca253a9de6050b21156d96413
https://doi.org/10.1096/fasebj.23.1_supplement.494.1
https://doi.org/10.1096/fasebj.23.1_supplement.494.1
Publikováno v:
Mutagenesis. 12(5)
Arsenic has been shown to inhibit methyl methane-sulphonate (MMS)-induced DNA repair but the exact mechanism remains controversial. The purpose of this investigation is to examine which step of DNA repair is most sensitive to arsenite (As) and how As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86fb99fa975babf673adedb38be354a
https://pubmed.ncbi.nlm.nih.gov/9379914
https://pubmed.ncbi.nlm.nih.gov/9379914