Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Hsien-Ming Hu"'
Autor:
Angel A. Ku, Hsien-Ming Hu, Xin Zhao, Khyati N. Shah, Sameera Kongara, Di Wu, Frank McCormick, Allan Balmain, Sourav Bandyopadhyay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Defining robust, penetrant synthetic lethal targets for cancer therapeutics is a challenge. Here, the authors demonstrate how pathway, genetic and cellular context dictates dependence on cancer targets.
Externí odkaz:
https://doaj.org/article/b6264ed197d149c5a5e05804786dbdb6
Autor:
Hsien-Ming Hu, Xin Zhao, Swati Kaushik, Lilliane Robillard, Antoine Barthelet, Kevin K. Lin, Khyati N. Shah, Andy D. Simmons, Mitch Raponi, Thomas C. Harding, Sourav Bandyopadhyay
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 918-929 (2018)
Summary: Chemotherapy is used to treat most cancer patients, yet our understanding of factors that dictate response and resistance to such drugs remains limited. We report the generation of a quantitative chemical-genetic interaction map in human mam
Externí odkaz:
https://doaj.org/article/c909b47692df44cdb6150df68cfc7bc1
Poly(ADP-Ribose) polymerase (PARP) inhibitors have shown wide utility in targeting cancers with defects in homologous recombination. Poly(ADP-ribose) glycohydrolase (PARG), reverses the action of PARP enzymes and may also be an anti-cancer target. Ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31806c8fc4733206378e0419344860d4
https://doi.org/10.21203/rs.3.rs-2231840/v1
https://doi.org/10.21203/rs.3.rs-2231840/v1
A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer
Autor:
Sourav Bandyopadhyay, Franziska Haderk, Emilie Gross, Khyati N. Shah, Victor Olivas, D. Ciznadija, Trever G. Bivona, Ido Sloma, Vincent B. Masto, Scott L. Weinrich, Xin Zhao, Nevan J. Krogan, Hsien-Ming Hu, John Jascur, Shigeki Nanjo, Swati Kaushik, Jeffery R. Johnson, Gwendolyn M. Jang
SUMMARYSignaling networks balance the activities of many physically interacting proteins and perturbations to this network influence downstream signaling, potentially leading to oncogenic states. Using affinity purification-mass spectrometry we defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc83a7b774349d894102eb9c332058a2
https://doi.org/10.1101/2020.07.02.185173
https://doi.org/10.1101/2020.07.02.185173
Autor:
Thomas C. Harding, Andrew Simmons, Swati Kaushik, Khyati N. Shah, Kevin K. Lin, Mitch Raponi, Sourav Bandyopadhyay, Xin Zhao, Antoine Barthelet, Hsien-Ming Hu, Lilliane Robillard
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 918-929 (2018)
Cell reports, vol 23, iss 3
Cell reports
Hu, H-M; Zhao, X; Kaushik, S; Robillard, L; Barthelet, A; Lin, KK; et al.(2018). A Quantitative Chemotherapy Genetic Interaction Map Reveals Factors Associated with PARP Inhibitor Resistance. CELL REPORTS, 23(3), 918-929. doi: 10.1016/j.celrep.2018.03.093. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1459w66m
Cell reports, vol 23, iss 3
Cell reports
Hu, H-M; Zhao, X; Kaushik, S; Robillard, L; Barthelet, A; Lin, KK; et al.(2018). A Quantitative Chemotherapy Genetic Interaction Map Reveals Factors Associated with PARP Inhibitor Resistance. CELL REPORTS, 23(3), 918-929. doi: 10.1016/j.celrep.2018.03.093. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1459w66m
SUMMARY Chemotherapy is used to treat most cancer patients, yet our understanding of factors that dictate response and resistance to such drugs remains limited. We report the generation of a quantitative chemical-genetic interaction map in human mamm
Autor:
Sameera Kongara, Sourav Bandyopadhyay, Di Wu, Angel A. Ku, Xin Zhao, Frank McCormick, Hsien-Ming Hu, Allan Balmain
Synthetic lethal screens have the potential to identify new vulnerabilities incurred by specific cancer mutations but have been hindered by lack of agreement between studies. Using KRAS as a model, we identified that published synthetic lethal screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38de83fefada43f4323feab7edb23336
Autor:
Sourav Bandyopadhyay, Andrew Simmons, Swati Kaushik, Xin Zhao, Antoine Barthelet, Thomas C. Harding, Kevin K. Lin, Lilliane Robillard, Mitch Raponi, Hsien-Ming Hu
SUMMARYNearly every cancer patient is treated with chemotherapy yet our understanding of factors that dictate response and resistance to such agents remains limited. We report the generation of a quantitative chemical-genetic interaction map in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bca202ac7dc49a60c4351d1d8524b1
Publikováno v:
Biochemical and Biophysical Research Communications. 402:129-134
Ewing's family tumors are characterized by a specific t(11;22) chromosomal translocation that results in the formation of EWS-Fli1 oncogenic fusion protein. To investigate the effects of EWS-Fli1 on gene expression, we carried out DNA microarray anal
Autor:
Xin Zhao, Hsien-Ming Hu, Erik Verschueren, John Jascur, Khyati N. Shah, Nevan J. Krogan, Jeffrey R. Johnson, Sourav Bandyopadhyay, John Von Dollen, Swati Kaushik, Gwendolyn M. Jang
Publikováno v:
Cancer Research. 78:3297-3297
Characterization of the genomic landscapes of cancer patients has provided valuable insights into the key oncogenic drivers and revolutionized the concept of precision treatment of patients. However, a key limitation is that targetable alterations ar
The Oncogenic TLS-ERG Fusion Protein Exerts Different Effects in Hematopoietic Cells and Fibroblasts
Autor:
Howard A. Chansky, Anna Zielinska-Kwiatkowska, Hsien-Ming Hu, Liu Yang, Gerald Juergen Roth, Michael L. Blackburn, Qi Mei, Hitoshi Ichikawa, Junhui Zou
Publikováno v:
Molecular and Cellular Biology. 25:6235-6246
The oncogenic TLS-ERG fusion protein is found in human myeloid leukemia and Ewing's sarcoma as a result of specific chromosomal translocation. To unveil the potential mechanism(s) underlying cellular transformation, we have investigated the effects o