Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hsieh Yao D. Chang"'
Autor:
Anne E. Mohan, Aaron S. Cote, Eric Khong, Keith A. Mattern, Michael Whittington, Kevin M. Maloney, Eric B. Sirota, Yee Swan Ang, Michael DiBenedetto, Anthony Diaz-Santana, Richard Desmond, Ivan H. Lee, Beata Tao, Muhammad Sofian Bin Asi Sihombing, Christopher Pridgen, Glenn Spencer, Hsieh Yao D. Chang, Kevin M. Sirk, Hong Ren, Si-Wei Zhang, Wenjun Liu, Embarek Alwedi, Cuixian Yang
Publikováno v:
Organic Process Research & Development. 25:541-551
The final chemical transformation and isolation in the synthesis of an active pharmaceutical ingredient (API), referred to as the Pure Step, is often chemically simple but scientifically, operation...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::050d565e3d00180c82c678ebb7b2a798
https://doi.org/10.1021/acs.oprd.0c00488
https://doi.org/10.1021/acs.oprd.0c00488
Autor:
Anne E. Mohan, Siqing Song, Hsieh Yao D. Chang, Si-Wei Zhang, Patrick Larpent, Wenjun Liu, Michael DiBenedetto, Eric B. Sirota, Michael J. Di Maso, Richard Desmond, Kevin M. Maloney, Ivan H. Lee, Alfred Y. Lee, Guy R. Humphrey, Embarek Alwedi, Hong Ren
Publikováno v:
Organic Process Research & Development. 24:2498-2504
The development of a sustainable commercial salt formation process for gefapixant citrate (MK-7264), an investigational new P2X3 antagonist for the treatment of chronic cough, is described. Due to ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::facd961a62dfed3fd28d482411a9320b
https://doi.org/10.1021/acs.oprd.0c00260
https://doi.org/10.1021/acs.oprd.0c00260
Autor:
Michael J. Di Maso, Embarek Alwedi, Guy R. Humphrey, Richard Desmond, Louis-Charles Campeau, Lisa Jellett, John R. Naber, Hong Ren, Hsieh Yao D. Chang, Douglas A. L. Otte, Hong Gao, Michael A. Zompa, Si-Wei Zhang, Gary E. Martin, Alfred Y. Lee, Wenjun Liu, Francisco J. Guzman, Kevin M. Maloney, Feng Peng, Elizabeth Fisher, Rebecca T. Ruck, Dan Lehnherr, Anne E. Mohan, Glenn Spencer, Siqing Song, Kallol Basu, Rebecca A. Arvary, Sachin Lohani
Publikováno v:
Organic Process Research & Development. 24:2445-2452
A robust, green, and sustainable manufacturing process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refrac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c8b1da5db499a674207974d58e42c1
https://doi.org/10.1021/acs.oprd.0c00248
https://doi.org/10.1021/acs.oprd.0c00248
Autor:
Chunli Huang, Siqing Song, Wenjun Liu, Priya Parganiha, Ping Zhuang, Sachin Lohani, Embarek Alwedi, Hong Ren, Daniel Bishara, Hsieh Yao D. Chang
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 215
Control of process impurities during manufacturing of drug substance is critical to ensure quality and process robustness. During commercial process development for the gefapixant citrate drug substance, several process impurities were found to deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02a42fbc241e333a46ab8bb2f85acbf
https://pubmed.ncbi.nlm.nih.gov/35483232
https://pubmed.ncbi.nlm.nih.gov/35483232
Autor:
Chunli Huang, Siqing Song, Wenjun Liu, Priya Parganiha, Ping Zhuang, Sachin Lohani, Embarek Alwedi, Hong Ren, Daniel Bishara, Hsieh Yao D. Chang
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24c7a76beb51c3af02c27217364e1e2d
https://doi.org/10.2139/ssrn.3992378
https://doi.org/10.2139/ssrn.3992378