Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Hsiaoju Lee"'
Autor:
Yi Zhu, Neha Kohli, Anthony Young, Malkah Sheldon, Jani Coni, Meera Rajasekaran, Lozen Robinson, Rea Chroneos, Shaipreeah Riley, Joseph W. Guarnieri, Joshua Jose, Nisha Patel, Douglas C. Wallace, Shihong Li, Hsiaoju Lee, Robert H. Mach, Meagan J. McManus
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1226 (2024)
Although the precise molecular mechanisms responsible for neuronal death and motor dysfunction in late-onset Parkinson’s disease (PD) are unknown, evidence suggests that mitochondrial dysfunction and neuroinflammation occur early, leading to a coll
Externí odkaz:
https://doaj.org/article/05f0dc0c9db44296bebf93cfdbde983b
Autor:
Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J. McManus, Robert H. Mach
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-9 (2023)
Externí odkaz:
https://doaj.org/article/993d43f6deb4414c8a047530c4269507
Autor:
Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J. McManus, Robert H. Mach
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Background Oxidative stress is implicated in the pathogenesis of the most common neurodegenerative diseases, such as Alzheimer’s disease (AD). However, tracking oxidative stress in the brain has proven difficult and impeded its use as a bi
Externí odkaz:
https://doaj.org/article/a3b82024f10c4b7c8060ea62d1e48ada
Autor:
Robert K. Doot, Jacob G. Dubroff, Joshua S. Scheuermann, Kyle J. Labban, Jenny Cai, Chia-Ju Hsieh, Shihong Li, Hsiaoju Lee, Erin K. Schubert, Catherine Hou, Regan Sheffer, Alexander Schmitz, Kuiying Xu, Robert H. Mach
Publikováno v:
EJNMMI Physics, Vol 5, Iss 1, Pp 1-12 (2018)
Abstract Background [18F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson’s disease, and schizophrenia. Preclinical rad
Externí odkaz:
https://doaj.org/article/c889333eed8045fbbd7ee7a3be611495
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 1, Iss 1, Pp 1-19 (2016)
Abstract Background Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. The aim of this
Externí odkaz:
https://doaj.org/article/72531512ab5e4db1bc45482096529f51
Autor:
Jonathan McConathy, Dong Zhou, Stephany E. Shockley, Lynne A. Jones, Elizabeth A. Griffin, Hsiaoju Lee, Susan J. Adams, Robert H. Mach
Publikováno v:
Molecular Imaging, Vol 9 (2010)
The ( R )- and ( S )-enantiomers of 2-amino-3-[1-(2-[ 18 F]fluoroethyl)-1 H -[1,2,3]triazol-4-yl]propanoic acid (4) were synthesized and evaluated in the rat 9L gliosarcoma brain tumor model using cell uptake assays, biodistribution studies, and micr
Externí odkaz:
https://doaj.org/article/84dd44c1611543ef8828b3197d110b81
Autor:
Reagan R. Wetherill, Robert K. Doot, Anthony J. Young, Hsiaoju Lee, Erin K. Schubert, Corinde E. Wiers, Frank T. Leone, Robert H. Mach, Henry R. Kranzler, Jacob G. Dubroff
Publikováno v:
Journal of Nuclear Medicine. 64:797-802
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cec464299b42d2226cf1888387abeb3b
https://doi.org/10.2967/jnumed.122.264529
https://doi.org/10.2967/jnumed.122.264529
Autor:
David A. Mankoff, Robert H. Mach, Hank F. Kung, Hsiaoju Lee, Eric Blankemeyer, Hoon Choi, Karl Ploessl, Brian P. Lieberman, Shihong Li, Austin R. Pantel, Rong Zhou
Supplemental Methods. SI-Fig 1 HPLC chromatogram of [18F]4F-Glu and [18F]4F-Gln mixture. SI-Fig 2 Comparison of T/B values obtained by two readers. SI-Fig 3 Comparison of T/B ratios obtained from different tumor ROI methods. SI-Fig 4 Comparison of T/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35458ae9c2e5779cff4fce0e60127565
https://doi.org/10.1158/0008-5472.22416504
https://doi.org/10.1158/0008-5472.22416504
Autor:
David A. Mankoff, Robert H. Mach, Hank F. Kung, Hsiaoju Lee, Eric Blankemeyer, Hoon Choi, Karl Ploessl, Brian P. Lieberman, Shihong Li, Austin R. Pantel, Rong Zhou
Glutaminolysis is a metabolic pathway adapted by many aggressive cancers, including triple-negative breast cancers (TNBC), to utilize glutamine for survival and growth. In this study, we examined the utility of [18F](2S,4R)4-fluoroglutamine ([18F]4F-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0272970429b925dd792fc11d9c8b2520
https://doi.org/10.1158/0008-5472.c.6509568.v1
https://doi.org/10.1158/0008-5472.c.6509568.v1
Publikováno v:
Cancer Research. 82:P5-08
OBJECTIVES: Upregulated glutamine metabolism is an important metabolic signature for aggressive and treatment-resistant cancers, including many triple negative breast cancers (TNBCs). Glutamate (Glu) produced from glutamine (Gln) via mitochondrial gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58754463f7b6da07d199e65bb4bb9869
https://doi.org/10.1158/1538-7445.sabcs21-p5-08-18
https://doi.org/10.1158/1538-7445.sabcs21-p5-08-18