Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Hsiao-Yen Ma"'
Autor:
Hsiao-Yen Ma, Elsa-Noah N’Diaye, Patrick Caplazi, Zhiyu Huang, Alexander Arlantico, Surinder Jeet, Aaron Wong, Hans D. Brightbill, Qingling Li, Weng Ruth Wong, Wendy Sandoval, Lucinda Tam, Robert Newman, Merone Roose-Girma, Ning Ding
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Bone morphogenetic protein 1 (BMP1) belongs to the astacin/BMP1/tolloid-like family of zinc metalloproteinases, which play a fundamental role in the development and formation of extracellular matrix (ECM). BMP1 mediates the cleavage of carbo
Externí odkaz:
https://doaj.org/article/e0c353ad1e8e4c3a9db3aafe0b1e52bb
Publikováno v:
PLoS ONE, Vol 7, Iss 10 (2012)
Externí odkaz:
https://doaj.org/article/afe665d69abc44d68c28d85e9fe838d9
Autor:
Jun Xu, Mariko Nonogaki, Ravi Madhira, Hsiao-Yen Ma, Ola Hermanson, Chrissa Kioussi, Michael K Gross
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e48573 (2012)
Chmp2b is closely related to Vps2, a key component of the yeast protein complex that creates the intralumenal vesicles of multivesicular bodies. Dominant negative mutations in Chmp2b cause autophagosome accumulation and neurodegenerative disease. Los
Externí odkaz:
https://doaj.org/article/0adb6ea7ffd14d8d8439ca082d5275fc
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42228 (2012)
Sequence specific transcription factors (SSTFs) combinatorially define cell types during development by forming recursively linked network kernels. Pitx2 expression begins during gastrulation, together with Hox genes, and becomes localized to the abd
Externí odkaz:
https://doaj.org/article/de99f6f158b84066919d9e523e9b5fda
Autor:
Hsiao-Yen Ma, Qingling Li, Weng Ruh Wong, Elsa-Noah N’Diaye, Patrick Caplazi, Hannah Bender, Zhiyu Huang, Alexander Arlantico, Surinder Jeet, Aaron Wong, Claire Emson, Hans Brightbill, Lucinda Tam, Robert Newman, Merone Roose-Girma, Wendy Sandoval, Ning Ding
Publikováno v:
Science Advances. 9
Idiopathic pulmonary fibrosis is a progressive fibrotic disease characterized by excessive deposition of (myo)fibroblast produced collagen fibrils in alveolar areas of the lung. Lysyl oxidases (LOXs) have been proposed to be the central enzymes that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2015a85d4411ba48474f981a155c8556
https://doi.org/10.1126/sciadv.adf0133
https://doi.org/10.1126/sciadv.adf0133
Inhibition of the TGF-β activating integrin, αvβ8, can dramatically enhance the effectiveness of checkpoint inhibition in multiple checkpoint resistant tumor models, but the mechanisms underlying this dramatic synergy have not been previously expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d0d7d425e707d0ef4b2dab3951e5eaa
https://doi.org/10.21203/rs.3.rs-1778271/v1
https://doi.org/10.21203/rs.3.rs-1778271/v1
Autor:
Ludmil B. Alexandrov, Hsiao-Yen Ma, Takahiro Nishio, Jun Xu, Xiao Liu, Pnina Brodt, Mengxi Sun, Ju Youn Kim, Alan R. Saltiel, Gen Yamamoto, Daniel Karin, Oswald Quehenberger, Gabriel Karin, Christopher Benner, Tatiana Kisseleva, Sara Brin Rosenthal, Hidekazu Tsukamoto, Edward A. Dennis, Iain H. McKillop, David A. Brenner, Yukinori Koyama, Shuang Liang, Peng Zhao, Sven Heinz, Michael Karin, Bin Gao
Publikováno v:
Journal of hepatology, vol 72, iss 5
Background & Aims Chronic alcohol consumption is a leading risk factor for the development of hepatocellular carcinoma (HCC), which is associated with a marked increase in hepatic expression of pro-inflammatory IL-17A and its receptor IL-17RA. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0783c613dc1f4a1004d0b0e22bd5f348
https://doi.org/10.1016/j.jhep.2019.12.016
https://doi.org/10.1016/j.jhep.2019.12.016
Autor:
Hsiao-Yen Ma, Jason A. Vander Heiden, Salil Uttarwar, Ying Xi, Elsa-Noah N'Diaye, Ryan LaCanna, Patrick Caplazi, Sarah Gierke, John Moffat, Paul J. Wolters, Ning Ding
Publikováno v:
The European respiratory journal.
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease characterised by aberrant fibroblast/myofibroblast accumulation and excessive collagen matrix deposition in the alveolar areas of lungs. As the first approved IPF medicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d46e3b2a33118a861e85285f75ffd8
https://pubmed.ncbi.nlm.nih.gov/36585256
https://pubmed.ncbi.nlm.nih.gov/36585256
Autor:
Paul J. Wolters, Elsa-Noah N’Diaye, Hsiao-Yen Ma, Bushra Husain, Thirumalai R. Ramalingam, Ryan P. Kelly, Alexander Arlantico, Katrina B. Morshead, Si Hyun Kim, Scot A. Marsters, Guiquan Jia, Charles Yu, Claire Emson, Merone Roose-Girma, Daryle Depianto, Ariel E. Feldstein, Lucinda Tam, Ryan LaCanna, Meredith Sagolla, Surinder Jeet, Zhiyu Huang, Hans Brightbill, Jason A. Vander Heiden, Aaron K. Wong, Nadia Martinez Martin, Ying Xi, Patrick Caplazi, Shuang Wu, Laura Lucio, Avi Ashkenazi, Ning Ding, Sarah Gierke
Publikováno v:
SSRN Electronic Journal.
Fibrosis or cirrhosis is the major risk factor associated with morbidity and mortality in patients with non-alcoholic steatohepatitis (NASH)-driven chronic liver disease. While numerous efforts have been made to identify mediators of the initiation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10945134be7b0fa798d6a8bb270d3693
https://doi.org/10.2139/ssrn.3966644
https://doi.org/10.2139/ssrn.3966644
Autor:
Aras N. Mattis, Valerie M. Weaver, Lan Wei, Steve S. Ho, Yusuf A. Hannun, Lorena Pantano, Meghan S. Mooring, Bryan C. Fuchs, Jennifer Y. Chen, Alan C. Mullen, Regina Español-Suñer, Diego dos Santos Ferreira, Dean Yimlamai, Andrew M. Tager, Daniel Canals, Raymond T. Chung, Joe M. Segal, Vikram R. Rao, Amy Yu, Johanna R. Schaub, Mai Sedki, Caroline C. Duwaerts, Sarani Ghoshal, Hsiao-Yen Ma, Nadia M. E. Ayad, Scott M. Turner, Jimmy Kuang-Hsien Hu, Benjamin Newcomb, Megan M. Marlow, Stephanie A. Christenson, Izolda Mileva, Dean Sheppard, Sarah Alsamman
Publikováno v:
Sci Transl Med
Science translational medicine, vol 12, iss 557
Science translational medicine, vol 12, iss 557
Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) as an antifibrotic target. We showed that tricyclic antidepressants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a4b8c3ed8a9921917b7e90c8313188
https://europepmc.org/articles/PMC7976849/
https://europepmc.org/articles/PMC7976849/