Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Hsiao-Ching Chuang"'
Autor:
Su-Lin Lee, Chih-Chien Chou, Hsiao-Ching Chuang, En-Chi Hsu, Po-Chen Chiu, Samuel K Kulp, John C Byrd, Ching-Shih Chen
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67149 (2013)
Although the rictor-mTOR complex (mTORC2) has been shown to act as phosphoinositide-dependent kinase (PDK)2 in many cell types, other kinases have also been implicated in mediating Ser473-Akt phosphorylation. Here, we demonstrated the cell line speci
Externí odkaz:
https://doaj.org/article/b2c8fdea46454f19ba16c77a553e7492
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47298 (2012)
Substantial evidence supports the oncogenic role of the E3 ubiquitin ligase S-phase kinase-associated protein 2 (Skp2) in many types of cancers through its ability to target a broad range of signaling effectors for ubiquitination. Thus, this oncogeni
Externí odkaz:
https://doaj.org/article/fb261384b1ab4fb8bf57b413a1d80acc
Autor:
Hsiao-Ching Chuang, 莊曉青
95
Due to the highly industrial development and consequently coastal construction in the western part of Taiwan, the ecosystem of the rivers and ocean were seriously polluted that has affected the related coastal resources. This study aims at th
Due to the highly industrial development and consequently coastal construction in the western part of Taiwan, the ecosystem of the rivers and ocean were seriously polluted that has affected the related coastal resources. This study aims at th
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/66023885735618453756
Autor:
Hsiao-Ching Chuang, 莊筱菁
93
Human GCMa is a zinc-containing transcription factor that plays a critical role for placenta development. hGCMa regulates the fusion of cytotrophoblasts into a syncytiotrophoblast layer, which is indispensable for the proper development of fe
Human GCMa is a zinc-containing transcription factor that plays a critical role for placenta development. hGCMa regulates the fusion of cytotrophoblasts into a syncytiotrophoblast layer, which is indispensable for the proper development of fe
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/57566863269535466720
Autor:
Min-Wu Chao, Po-Chen Chu, Hsiao-Ching Chuang, Fang-Hsiu Shen, Chih-Chien Chou, En-Chi Hsu, Lauren E. Himmel, Han-Li Huang, Huang-Ju Tu, Samuel K. Kulp, Che-Ming Teng, Ching-Shih Chen
Publikováno v:
Oncotarget
Here, we report a novel non-epigenetic function of histone deacetylase (HDAC) 8 in activating cancer stem cell (CSC)-like properties in breast cancer cells by enhancing the stability of Notch1 protein. The pan-HDAC inhibitors AR-42 and SAHA, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bf5eca6cb7e8c6dba7731f9c2ac0f3
https://pubmed.ncbi.nlm.nih.gov/26625202
https://pubmed.ncbi.nlm.nih.gov/26625202
Publikováno v:
Pharmacological Research. 117:370-376
The clear importance of mutated KRAS as a therapeutic target has driven the investigation of multiple approaches to inhibit oncogenic KRAS signaling at different molecular levels. However, no KRAS-targeted therapy has reached the clinic to date, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19f379dc562c8842b046255c9704684
https://doi.org/10.1016/j.phrs.2017.01.006
https://doi.org/10.1016/j.phrs.2017.01.006
Publikováno v:
Current Pharmaceutical Design. 20:2607-2618
Adenosine monophosphate-activated protein kinase (AMPK) is a key player in maintaining energy homeostasis in response to metabolic stress. Beyond diabetes and metabolic syndrome, there is a growing interest in the therapeutic exploitation of the AMPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2c73a7d5c9ae91f4421995b1f983ad
https://doi.org/10.2174/13816128113199990485
https://doi.org/10.2174/13816128113199990485
Publikováno v:
Journal of Biological Chemistry. 287:43639-43650
The mRNA-stabilizing protein HuR acts a stress response protein whose function and/or protein stability are modulated by diverse stress stimuli through posttranslational modifications. Here, we report a novel mechanism by which metabolic stress facil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a67bd3adddf88c22b6a2e5d69da961
https://doi.org/10.1074/jbc.m112.393678
https://doi.org/10.1074/jbc.m112.393678
Autor:
Samuel K. Kulp, Hao Yu Hsieh, Hsiao Ching Chuang, Dasheng Wang, Shu-Chuan Weng, Po Hsien Huang, Ching-Shih Chen
Publikováno v:
Journal of Medicinal Chemistry. 52:5642-5648
This study is aimed at the pharmacological exploitation of alpha-tocopheryl succinate (1) to develop potent antiadhesion agents. Considering the structural cooperativity between the phytyl chain and the carboxylic terminus in determining the antiadhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4680ec67d3b31054a05341a48b556c8
https://doi.org/10.1021/jm9002457
https://doi.org/10.1021/jm9002457