Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Hsiao Mei Lu"'
Autor:
Shumei Kato, Bing Li, Jacob J. Adashek, Seong Won Cha, Daniella Bianchi-Frias, Dajun Qian, Lisa Kim, Tiffany W so, Marcus Mitchell, Naoki Kamei, Robert Hoiness, Jayne Hoo, Phillip N. Gray, Teruaki Iyama, Masahide Kashiwagi, Hsiao-Mei Lu, Razelle Kurzrock
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Major immunotherapy challenges include a limited number of predictive biomarkers and the unusual imaging features post-therapy, such as pseudo-progression, which denote immune infiltrate-mediated tumor enlargement. Such phenomena confound clinical de
Externí odkaz:
https://doaj.org/article/35d4a165818142dd93df23ae9ead722d
Autor:
Tyler Landrith, Bing Li, Ashley A. Cass, Blair R. Conner, Holly LaDuca, Danielle B. McKenna, Kara N. Maxwell, Susan Domchek, Nichole A. Morman, Christopher Heinlen, Deborah Wham, Cathryn Koptiuch, Jennie Vagher, Ragene Rivera, Ann Bunnell, Gayle Patel, Jennifer L. Geurts, Morgan M. Depas, Shraddha Gaonkar, Sara Pirzadeh-Miller, Rebekah Krukenberg, Meredith Seidel, Robert Pilarski, Meagan Farmer, Khateriaa Pyrtel, Kara Milliron, John Lee, Elizabeth Hoodfar, Deepika Nathan, Amanda C. Ganzak, Sitao Wu, Huy Vuong, Dong Xu, Aarani Arulmoli, Melissa Parra, Lily Hoang, Bhuvan Molparia, Michele Fennessy, Susanne Fox, Sinead Charpentier, Julia Burdette, Tina Pesaran, Jessica Profato, Brandon Smith, Ginger Haynes, Emily Dalton, Joy Rae-Radecki Crandall, Ruth Baxter, Hsiao-Mei Lu, Brigette Tippin-Davis, Aaron Elliott, Elizabeth Chao, Rachid Karam
Publikováno v:
npj Precision Oncology, Vol 4, Iss 1, Pp 1-9 (2020)
Abstract Germline variants in tumor suppressor genes (TSGs) can result in RNA mis-splicing and predisposition to cancer. However, identification of variants that impact splicing remains a challenge, contributing to a substantial proportion of patient
Externí odkaz:
https://doaj.org/article/50f2e0c212b24359a87e5f0fd59980ac
Autor:
Suzette Farber-Katz, Vickie Hsuan, Sitao Wu, Tyler Landrith, Huy Vuong, Dong Xu, Bing Li, Jayne Hoo, Stephanie Lam, Sarah Nashed, Deborah Toppmeyer, Phillip Gray, Ginger Haynes, Hsiao-Mei Lu, Aaron Elliott, Brigette Tippin Davis, Rachid Karam
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Clinical genetic testing for hereditary breast and ovarian cancer (HBOC) is becoming widespread. However, the interpretation of variants of unknown significance (VUS) in HBOC genes, such as the clinically actionable genes BRCA1 and BRCA2, remain a ch
Externí odkaz:
https://doaj.org/article/ac330a471ac74523a1d861cc1c74206b
Autor:
Dajun Qian, Shuwei Li, Yuan Tian, Jacob W Clifford, Brice A J Sarver, Tina Pesaran, Chia-Ling Gau, Aaron M Elliott, Hsiao-Mei Lu, Mary Helen Black
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203553 (2018)
There is a growing need to develop variant prediction tools capable of assessing a wide spectrum of evidence. We present a Bayesian framework that involves aggregating pathogenicity data across multiple in silico scores on a gene-by-gene basis and mu
Externí odkaz:
https://doaj.org/article/7ece0e1b0d5b466fa03f5963d5b66717
Autor:
Andrew J. Shih, Tomi Jun, Andrew D. Skol, Riyue Bao, Lei Huang, Sapana Vora, Megan E. McNerney, Eric A. Hungate, Michelle M. Le Beau, Richard A. Larson, Aaron Elliott, Hsiao‐Mei Lu, Robert Huether, Felicia Hernandez, Friedrich Stölzel, James M. Allan, Kenan Onel
Publikováno v:
British journal of haematologyReferences.
Some patients with therapy-related myeloid neoplasms (t-MN) may have unsuspected inherited cancer predisposition syndrome (CPS). We propose a set of clinical criteria to identify t-MN patients with high risk of CPS (HR-CPS). Among 225 t-MN patients w
Autor:
Holly LaDuca, Kelly D Farwell, Huy Vuong, Hsiao-Mei Lu, Wenbo Mu, Layla Shahmirzadi, Sha Tang, Jefferey Chen, Shruti Bhide, Elizabeth C Chao
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170843 (2017)
BACKGROUND:With the expanded availability of next generation sequencing (NGS)-based clinical genetic tests, clinicians seeking to test patients with Mendelian diseases must weigh the superior coverage of targeted gene panels with the greater number o
Externí odkaz:
https://doaj.org/article/ae1ef351153e4b7c99d804195565611d
Autor:
Shuwei Li, Robert Hoiness, Siqun Lilly Zheng, Brian T. Helfand, Mary Helen Black, Jun Wei, Jefferey Chen, Jianfeng Xu, Kathleen E. Wiley, Stephanie Gutierrez, Brigette Tippin-Davis, Min-Tzu Lo, Hsiao Mei Lu, William B. Isaacs, Holly LaDuca, Zhuqing Shi, Marta Gielzak
Publikováno v:
The Prostate
Background Genome‐wide association studies have identified over 100 single‐nucleotide polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores (PRS) based on their combined genotypes have been developed for risk stra
Autor:
Elizabeth C. Chao, Sitao Wu, Bryony A. Thompson, Holly LaDuca, Hsiao-Mei Lu, Shuwei Li, Stephanie Gutierrez, Mary Helen Black, Dajun Qian, Tina Pesaran
Publikováno v:
Journal of Medical Genetics. 57:62-69
BackgroundPathogenic variants in mismatch repair (MMR) genes (MLH1, MSH2,MSH6andPMS2) increase risk for Lynch syndrome and related cancers. We quantified tumour characteristics to assess variant pathogenicity for germline MMR genes.MethodsAmong 4740
Autor:
Phillip Gray, Beth Souders, Swati Shah, Chia Ling Gau, Carla Mason, Megan L. Landsverk, Negar Ghahramani, Brittany Dougall, Brigette Tippin-Davis, Kory Jasperson, Stephanie Gutierrez, Melissa R.F. Truelson, Kelly Fulk, Elizabeth C. Chao, Jessica Profato, Daniel Chen, Melissa Pronold, Hsiao Mei Lu, Mary Helen Black, Holly LaDuca, Monalyn Umali Salvador
Publikováno v:
Journal of Clinical Oncology
PURPOSE The current diagnostic testing algorithm for Lynch syndrome (LS) is complex and often involves multiple follow-up germline and somatic tests. We aimed to describe the results of paired tumor/germline testing performed on a large cohort of pat
Autor:
Hansook Kim Chong, Tao Wang, Hsiao-Mei Lu, Sara Seidler, Hong Lu, Steven Keiles, Elizabeth C Chao, A J Stuenkel, Xiang Li, Aaron M Elliott
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97408 (2014)
Breast cancer is the most commonly diagnosed cancer in women, with 10% of disease attributed to hereditary factors. Although BRCA1 and BRCA2 account for a high percentage of hereditary cases, there are more than 25 susceptibility genes that different
Externí odkaz:
https://doaj.org/article/06aa0d5c8ec84c5087fce8b0b5203155