Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hsiao‐Lin V. Wang"'
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background CD-1 is an outbred mouse stock that is frequently used in toxicology, pharmacology, and fundamental biomedical research. Although inbred strains are typically better suited for such studies due to minimal genetic variability, outb
Externí odkaz:
https://doaj.org/article/09779d1438674ca8ba3c0692f49e57dc
Autor:
Hannah Gabriela Valverde de Morales, Hsiao‐Lin V. Wang, Kathryn Garber, Xiaodong Cheng, Victor G. Corces, Hong Li
Publikováno v:
American Journal of Medical Genetics Part A. 191:718-729
Monoallelic variants of CTCF cause an autosomal dominant neurodevelopmental disorder with a wide range of features, including impacts on the brain, growth, and craniofacial development. A growing number of subjects with CTCF-related disorder (CRD) ha
Autor:
Hsiao-Lin V. Wang, Austin M. Veire, Tania F. Gendron, Marla Gearing, Jonathan D. Glass, Peng Jin, Victor G. Corces, Zachary T. McEachin
Repeat expansions in theC9orf72gene are the most common genetic cause of amyotrophic lateral sclerosis and familial frontotemporal dementia (ALS/FTD). To identify molecular defects that take place in the dorsolateral frontal cortex of patients withC9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9126d2b86f1b92603661ef0cd2f9b156
https://doi.org/10.1101/2023.01.12.523820
https://doi.org/10.1101/2023.01.12.523820
Autor:
Yoon Hee, Jung, Hsiao-Lin V, Wang, Daniel, Ruiz, Brianna J, Bixler, Hannah, Linsenbaum, Jian-Feng, Xiang, Samantha, Forestier, Andrew M, Shafik, Peng, Jin, Victor G, Corces
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(50)
The mechanisms by which environmentally-induced epiphenotypes are transmitted transgenerationally in mammals are poorly understood. Here we show that exposure of pregnant mouse females to bisphenol A (BPA) results in obesity in the F2 progeny due to
Autor:
Hsiao-Lin V. Wang, Arturo Hernandez, Emilie F. Rissman, Jill Escher, Wei Yan, Victor G. Corces
Publikováno v:
Journal of Autism and Developmental Disorders. 52:4608-4624
Investigations into the etiology of autism spectrum disorders have been largely confined to two realms: variations in DNA sequence and somatic developmental exposures. Here we suggest a third route—disruption of the germline epigenome induced by ex
Autor:
Hsiao-Lin V. Wang, Victor G. Corces
Publikováno v:
Developmental cell. 56(18)
Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF o
Autor:
Hsiao-Lin V. Wang, Julia A. Chekanova
Publikováno v:
RNA. 25:1242-1258
The precise spatial and temporal control of gene expression requires the coordinated action of genomic cis-regulatory elements (CREs), including transcriptional enhancers. However, our knowledge of enhancers in plants remains rudimentary and only a f
Publikováno v:
Biol Reprod
One in 54 children in the U.S. is diagnosed with Autism Spectrum Disorder (ASD). De novo germline and somatic mutations cannot account for all cases of ASD, suggesting that epigenetic alterations triggered by environmental exposures may be responsibl
Autor:
Daniel Ruiz, Jian-Feng Xiang, Yoon Jung, Brianna J. Bixler, Hannah Linsenbaum, Andrew M. Shafik, Hsiao-Lin V. Wang, Peng Jin, Victor G. Corces
The mechanisms by which epiphenotypes are transmitted transgenerationally through the parental germlines are poorly understood. Here we show that exposure of pregnant mouse F0 females during E7.5-E13.5 to bisphenol A results in obesity in the F2 prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1836ca192ff7f4729d5c150f39366479
https://doi.org/10.21203/rs.3.rs-114585/v1
https://doi.org/10.21203/rs.3.rs-114585/v1
Autor:
M. Ryan Corces, Samantha Forestier, Andrew M. Shafik, Peng Jin, Yoon Hee Jung, Fiorella C. Grandi, Hannah Linsenbaum, Hsiao-Lin V. Wang, Jian-Feng Xiang, Daniel Ruiz, Brianna J. Bixler, Victor G. Corces
Transgenerational transmission of epiphenotypes is poorly understood. Here we show that exposure of pregnant mouse F0 females to BPA results in obesity in the F2 progeny due to increased food intake and leptin resistance. This epiphenotype can be tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fe3ecd7d4cf7307006c761f62beb781
https://doi.org/10.1101/2020.11.20.391672
https://doi.org/10.1101/2020.11.20.391672