Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Hsiang-Ting Ho"'
Autor:
Brittany A. Elliott, Hsiang-Ting Ho, Srivathsan V. Ranganathan, Sweta Vangaveti, Olga Ilkayeva, Hala Abou Assi, Alex K. Choi, Paul F. Agris, Christopher L. Holley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The post-transcriptional modification of mRNAs provides an additional layer to gene expression regulation. Here the authors show that 2′-O-methylation mediated by box C/D snoRNAs and fibrillarin can inhibit the translation of target mRNAs.
Externí odkaz:
https://doaj.org/article/b5583f16311b4eff9351aede56bc09e1
Autor:
Przemysław B. Radwański, PharmD, PhD, Hsiang-Ting Ho, PhD, Rengasayee Veeraraghavan, PhD, Lucia Brunello, PhD, Bin Liu, PhD, Andriy E. Belevych, PhD, Sathya D. Unudurthi, PhD, Michael A. Makara, PhD, Silvia G. Priori, MD, PhD, Pompeo Volpe, PhD, Antonis A. Armoundas, PhD, Wolfgang H. Dillmann, MD, Bjorn C. Knollmann, MD, PhD, Peter J. Mohler, PhD, Thomas J. Hund, PhD, Sándor Györke, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 4, Pp 251-266 (2016)
Although triggered arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT) are often caused by increased levels of circulating catecholamines, the mechanistic link between β-adrenergic receptor (AR) stimulation and the sub
Externí odkaz:
https://doaj.org/article/14f969abcf034b40ad9a83088e11255d
Autor:
Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Tropo
Externí odkaz:
https://doaj.org/article/9828c585327046c3b5306a0cb5e0d215
Autor:
Bin Liu, Shane D. Walton, Hsiang‐Ting Ho, Andriy E. Belevych, Svetlana B. Tikunova, Ingrid Bonilla, Vikram Shettigar, Bjorn C. Knollmann, Silvia G. Priori, Pompeo Volpe, Przemysław B. Radwański, Jonathan P. Davis, Sándor Györke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
BackgroundCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine rece
Externí odkaz:
https://doaj.org/article/17b2d1203c6b4fb18ec412e87dd32e52
Autor:
Gwendolen Lorch, Serge Viatchenko-Karpinski, Hsiang-Ting Ho, Wessel P. Dirksen, Ramiro E. Toribio, John Foley, Sandor Györke, Thomas J. Rosol
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 5, Pp 428-438 (2011)
The calcium-sensing receptor (CaR) is responsible for the regulation of extracellular calcium (Ca2+o) homeostasis. CaR activation has been shown to increase proliferation in several cancer cell lines; however, its presence or function has never been
Externí odkaz:
https://doaj.org/article/13d80f320c474a228fde315f88000ace
Autor:
Andriy E Belevych, Hsiang-Ting Ho, Radmila Terentyeva, Ingrid M Bonilla, Dmitry Terentyev, Cynthia A Carnes, Sandor Gyorke, George E Billman
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78414 (2013)
It has been proposed that dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) can reduce the risk of ventricular arrhythmias in post-MI patients. Abnormal Ca(2+) handling has been implicated in the genesis of post-MI ventricular arrhythmias. Ther
Externí odkaz:
https://doaj.org/article/bb28aef6fe6e43e6bb1b815ecbc9f852
Autor:
Christopher J Traynham, Steve R Roof, Honglan Wang, Robert A Prosak, Lifei Tang, Serge Viatchenko-Karpinski, Hsiang-Ting Ho, Ira O Racoma, Dominic J Catalano, Xin Huang, Yongbin Han, Shang-U Kim, Sandor Gyorke, George E Billman, Frederick A Villamena, Mark T Ziolo
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52005 (2012)
Nitric oxide (NO) and superoxide (O(2) (-)) are important cardiac signaling molecules that regulate myocyte contraction. For appropriate regulation, NO and O(2) (.-) must exist at defined levels. Unfortunately, the NO and O(2) (.-) levels are altered
Externí odkaz:
https://doaj.org/article/8e0cb70510354f61a6e1f4f77eeaac16
Autor:
Andriy E Belevych, Sarah E Sansom, Radmila Terentyeva, Hsiang-Ting Ho, Yoshinori Nishijima, Mickey M Martin, Hitesh K Jindal, Jennifer A Rochira, Yukiko Kunitomo, Maha Abdellatif, Cynthia A Carnes, Terry S Elton, Sandor Györke, Dmitry Terentyev
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28324 (2011)
In heart failure (HF), arrhythmogenic spontaneous sarcoplasmic reticulum (SR) Ca(2+) release and afterdepolarizations in cardiac myocytes have been linked to abnormally high activity of ryanodine receptors (RyR2s) associated with enhanced phosphoryla
Externí odkaz:
https://doaj.org/article/82b72743a2f04eee91cbcfb491c230a0
Autor:
Senthil Thambidorai, Hsiang-Ting Ho, Sándor Györke, Bjorn C. Knollmann, George E. Billman, Anuradha Kalyanasundaram
Publikováno v:
Heart Rhythm. 15:430-441
Background Long-term aerobic exercise alters autonomic balance, which may not be favorable in heart rate (HR)–dependent arrhythmic diseases including catecholaminergic polymorphic ventricular tachycardia (CPVT) because of preexisting bradycardia an
Publikováno v:
The FASEB Journal. 33