Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Hsiang-Chun Chang"'
Autor:
Yuki Tatekoshi, Chunlei Chen, Jason Solomon Shapiro, Hsiang-Chun Chang, Malorie Blancard, Davi M Lyra-Leite, Paul W Burridge, Matthew Feinstein, Richard D'Aquila, Priscilla Hsue, Hossein Ardehali
Publikováno v:
eLife, Vol 13 (2024)
Heart failure with preserved ejection fraction (HFpEF) is commonly found in persons living with HIV (PLWH) even when antiretroviral therapy suppresses HIV viremia. However, studying this condition has been challenging because an appropriate animal mo
Externí odkaz:
https://doaj.org/article/d554a4e305244435abefadbdb0b10274
Autor:
Xiaoyan Yang, Hsiang-Chun Chang, Yuki Tatekoshi, Amir Mahmoodzadeh, Maryam Balibegloo, Zeinab Najafi, Rongxue Wu, Chunlei Chen, Tatsuya Sato, Jason Shapiro, Hossein Ardehali
Publikováno v:
eLife, Vol 12 (2023)
Sirtuins (SIRT) exhibit deacetylation or ADP-ribosyltransferase activity and regulate a wide range of cellular processes in the nucleus, mitochondria, and cytoplasm. The role of the only sirtuin that resides in the cytoplasm, SIRT2, in the developmen
Externí odkaz:
https://doaj.org/article/befc7f16030043058f3f817b757b66ac
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102064- (2023)
Summary: Impaired mitochondrial iron metabolism is associated with aging and a variety of diseases, and there is a growing need to accurately quantify mitochondrial iron levels. This protocol provides an optimized method for evaluating non-heme and h
Externí odkaz:
https://doaj.org/article/81e1c7f5b98b446aa9e1bbfe57baef27
Autor:
Hidemichi Kouzu, Yuki Tatekoshi, Hsiang-Chun Chang, Jason S. Shapiro, Warren A. McGee, Adam De Jesus, Issam Ben-Sahra, Zoltan Arany, Jonathan Leor, Chunlei Chen, Perry J. Blackshear, Hossein Ardehali
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Pregnancy is associated with substantial physiological changes of the heart, and disruptions in these processes can lead to peripartum cardiomyopathy (PPCM). The molecular processes that cause physiological and pathological changes in the heart durin
Externí odkaz:
https://doaj.org/article/ce1ae0e9ad7f4a358703ee95ae7ff468
Publikováno v:
eLife, Vol 11 (2022)
Iron is an essential molecule for biological processes, but its accumulation can lead to oxidative stress and cellular death. Due to its oxidative effects, iron accumulation is implicated in the process of aging and neurodegenerative diseases. Howeve
Externí odkaz:
https://doaj.org/article/2ccba3a385ad490398380fb814d3bb85
Autor:
Hsiang-Chun Chang, Jason Solomon Shapiro, Xinghang Jiang, Grant Senyei, Teruki Sato, Justin Geier, Konrad T Sawicki, Hossein Ardehali
Publikováno v:
eLife, Vol 10 (2021)
Chronic loss of Augmenter of Liver Regeneration (ALR) results in mitochondrial myopathy with cataracts; however, the mechanism for this disorder remains unclear. Here, we demonstrate that loss of ALR, a principal component of the MIA40/ALR protein im
Externí odkaz:
https://doaj.org/article/09ea966f91184bedb8ce060eab6be3c0
Autor:
Chiung-Chyi Shen, Shan-hui Hsu, Kai-Bo Chang, Chun-An Yeh, Hsiang-Chun Chang, Cheng-Ming Tang, Yi-Chin Yang, Hsien-Hsu Hsieh, Huey-Shan Hung
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1632 (2021)
In this study, polyethylene glycol (PEG) with hydroxyapatite (HA), with the incorporation of physical gold nanoparticles (AuNPs), was created and equipped through a surface coating technique in order to form PEG-HA-AuNP nanocomposites. The surface mo
Externí odkaz:
https://doaj.org/article/a14a46415f944a958b206f1ac8bbc418
Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
Autor:
Amy K. Rines, Hsiang-Chun Chang, Rongxue Wu, Tatsuya Sato, Arineh Khechaduri, Hidemichi Kouzu, Jason Shapiro, Meng Shang, Michael A. Burke, Eltyeb Abdelwahid, Xinghang Jiang, Chunlei Chen, Tenley A. Rawlings, Gary D. Lopaschuk, Paul T. Schumacker, E. Dale Abel, Hossein Ardehali
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabol
Externí odkaz:
https://doaj.org/article/bae6e26f24c34045be0fbe2c38eff574
Autor:
Hsiang‐Chun Chang, Rongxue Wu, Meng Shang, Tatsuya Sato, Chunlei Chen, Jason S Shapiro, Ting Liu, Anita Thakur, Konrad T Sawicki, Sathyamangla VN Prasad, Hossein Ardehali
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 3, Pp 247-267 (2016)
Abstract Excess cellular iron increases reactive oxygen species (ROS) production and causes cellular damage. Mitochondria are the major site of iron metabolism and ROS production; however, few studies have investigated the role of mitochondrial iron
Externí odkaz:
https://doaj.org/article/e6b2dfb41f894ce0b3d39c6f95f0a18b
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 1 (2017)
Externí odkaz:
https://doaj.org/article/cc793c654df2482cafeec7b435f208ed