Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Hsiang‐i Tsai"'
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Cancer stem cells (CSCs), with their ability of self-renewal, unlimited proliferation, and multi-directional differentiation, contribute to tumorigenesis, metastasis, recurrence, and resistance to conventional therapy and immunotherapy. Elim
Externí odkaz:
https://doaj.org/article/b7ba04c52cfe4cdd9b336e90ea8b2bd1
Autor:
Youmei Xiao, Zhanxue Xu, Yuan Cheng, Rufan Huang, Yuan Xie, Hsiang-i Tsai, Hualian Zha, Lifang Xi, Kai Wang, Xiaoli Cheng, Yanfeng Gao, Changhua Zhang, Fang Cheng, Hongbo Chen
Publikováno v:
Biomaterials Research, Vol 27, Iss 1, Pp 1-17 (2023)
Abstract Background Ferroptosis, iron-dependent cell death, is an established mechanism for cancer suppression, particularly in hepatocellular carcinoma (HCC). Sorafenib (SOR), a frontline drug for the treatment of HCC, induces ferroptosis by inhibit
Externí odkaz:
https://doaj.org/article/f74a3ac7a6094723b9a10263917f6c47
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It has a poor response to conventional therapy and has an extremely poor 5-year survival rate. PDAC is driven by multiple oncogene mutations, with the highest mutat
Externí odkaz:
https://doaj.org/article/e0022ea77daf463c8019f7cb07715eec
Autor:
Hsiang-i Tsai, Yanping Wu, Rui Huang, Dandan Su, Yingyi Wu, Xiaoyan Liu, Linglu Wang, Zhanxue Xu, Yuxin Pang, Chong Sun, Chao He, Fan Shu, Haitao Zhu, Dongqing Wang, Fang Cheng, Laiqiang Huang, Hongbo Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1913-1927 (2022)
Mutations in the plant homeodomain-like finger protein 6 (PHF6) gene are strongly associated with acute myeloid (AML) and T-cell acute lymphoblastic leukemia (T-ALL). In this study, we demonstrated that PHF6 can bind to H3K9me3 and H3K27me1 on the nu
Externí odkaz:
https://doaj.org/article/5b2c474252c04c8f97240b490da672ac
Autor:
Hsiang‐i Tsai, Xiaobin Zeng, Longshan Liu, Shengchang Xin, Yingyi Wu, Zhanxue Xu, Huanxi Zhang, Gan Liu, Zirong Bi, Dandan Su, Min Yang, Yijing Tao, Changxi Wang, Jing Zhao, John E Eriksson, Wenbin Deng, Fang Cheng, Hongbo Chen
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp 1-18 (2021)
Abstract Herein, we demonstrate that NFAT, a key regulator of the immune response, translocates from cytoplasm to nucleolus and interacts with NF45/NF90 complex to collaboratively promote rDNA transcription via triggering the directly binding of NF45
Externí odkaz:
https://doaj.org/article/a63fdeff89ba40b9b30a6caeff5ad0b3
Autor:
Hsiang‐i Tsai, Yingyi Wu, Xiaoyan Liu, Zhanxue Xu, Longshan Liu, Changxi Wang, Huanxi Zhang, Yisheng Huang, Linglu Wang, Weixian Zhang, Dandan Su, Fahim Ullah Khan, Xiaofeng Zhu, Rongya Yang, Yuxin Pang, John E. Eriksson, Haitao Zhu, Dongqing Wang, Bo Jia, Fang Cheng, Hongbo Chen
Publikováno v:
Advanced Science, Vol 9, Iss 3, Pp n/a-n/a (2022)
Abstract There is an urgent need for developing new immunosuppressive agents due to the toxicity of long‐term use of broad immunosuppressive agents after organ transplantation. Comprehensive sample analysis revealed dysregulation of FGL1/LAG‐3 an
Externí odkaz:
https://doaj.org/article/a4a4e247d861499594f2f2d7c2d0b994
Autor:
Hualian Zha, Zhanxue Xu, Xichao Xu, Xingyu Lu, Peilin Shi, Youmei Xiao, Hsiang-I Tsai, Dandan Su, Fang Cheng, Xiaoli Cheng, Hongbo Chen
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1263 (2022)
PD-1 inhibitor Keytruda combined with chemotherapy for Triple-negative breast cancer (TNBC) has been approved for FDA, successfully representing the combination therapy of immunotherapy and chemotherapy for the first time in 2020. However, PD-L1 inhi
Externí odkaz:
https://doaj.org/article/7362a1b4f8824d5e93f0ea53f1f51c76
Autor:
Dandan Su, Hsiang-I Tsai, Zhanxue Xu, Fuxia Yan, Yingyi Wu, Youmei Xiao, Xiaoyan Liu, Yanping Wu, Sepideh Parvanian, Wangshu Zhu, John E. Eriksson, Dongqing Wang, Haitao Zhu, Hongbo Chen, Fang Cheng
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Excessive and persistent inflammation after injury lead to chronic wounds, increased tissue damage or even aggressive carcinogenic transformation. Effective wound repair could be achieved by inhibiting overactive immune cells to the injured site. In
Externí odkaz:
https://doaj.org/article/22c9307f1ca7495f92ef4ae29324589d
Autor:
Fahim Ullah Khan, Nana Yaa Gyaama Owusu-Tieku, Xiaoyong Dai, Kewei Liu, Yanping Wu, Hsiang-I Tsai, Hongbo Chen, Chunhui Sun, Laiqiang Huang
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Emerging evidence suggests that fibromodulin (FMOD), an extracellular matrix protein, is associated with cancer, and yet little is known about the regulation of FMOD expression and its role in cancer metastasis. Aspirin, a classic anti-inflammatory d
Externí odkaz:
https://doaj.org/article/b77b7784d5c047f18acacee67c4fb411
Autor:
Hsiang-I Tsai, Lijuan Jiang, Xiaowei Zeng, Hongbo Chen, Zihuang Li, Wei Cheng, Jinxie Zhang, Jie Pan, Dong Wan, Li Gao, Zhenhua Xie, Laiqiang Huang, Lin Mei, Gan Liu
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The clinical applications of platinum-based antitumor agents are still largely limited by severe side effects as well as multidrug resistance (MDR). To solve these problems, we developed an 1,2-diaminocyclohexane-platinum(II) (DACHPt)-loaded nanopart
Externí odkaz:
https://doaj.org/article/2a52798a0620425c88c9527a8b9a5e30