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Multiple system atrophy (MSA) is a debilitating movement disorder with unknown etiology. Patients present characteristic parkinsonism and/or cerebellar dysfunction in the clinical phase, resulting from progressive deterioration in the nigrostriatal a

Externí odkaz: https://doaj.org/article/9d82557359374461b6bb5b852876a58f

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Adaptive structural changes in the motor cortex and white matter in Parkinson’s disease

Autor: YuHong Fu, Liche Zhou, Hongyun Li, Jen-Hsiang T. Hsiao, Binyin Li, Onur Tanglay, Andrew D. Auwyang, Elinor Wang, Jieyao Feng, Woojin S. Kim, Jun Liu, Glenda M. Halliday

Publikováno v: Acta Neuropathologica. 144:861-879

Parkinson’s disease (PD) is a movement disorder characterized by the early loss of nigrostriatal dopaminergic pathways producing significant network changes impacting motor coordination. Recently three motor stages of PD have been proposed (a silen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4459c01fb09e0585d575b0d93d7687b8
https://doi.org/10.1007/s00401-022-02488-3

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Akademický článek

Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain

Autor: Jen-Hsiang T. Hsiao, Sivaraman Purushothuman, Poul H. Jensen, Glenda M. Halliday, Woojin Scott Kim

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Multiple system atrophy (MSA) is a progressive neurodegenerative disease clinically characterized by parkinsonism and cerebellar ataxia, and pathologically by oligodendrocyte α-synuclein inclusions. Genetic variants of COQ2 are associated with an in

Externí odkaz: https://doaj.org/article/c67e769da08242df85e5a5bb28ac1eef

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