Výsledky vyhledávání - "Hsia Lien Lin"

Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds

Autor: Paul F. Hollenberg, Haoming Zhang, Jaime D’Agostino, Hsia Lien Lin, Vyvyca J. Walker

Publikováno v: Drug Metabolism and Disposition. 45:990-999

The mechanism-based inactivation of human CYP2J2 by three terminal acetylenic compounds: N-(methylsulfonyl)-6-(2-propargyloxyphenyl)hexanamide (MS), 17-octadecynoic acid (OD), and danazol (DZ) was investigated. The loss of hydroxyebastine (OHEB) carb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2162cde4c0a62bdf9500dae81fb4ac5b
https://doi.org/10.1124/dmd.117.075846

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Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition

Autor: Hsia Lien Lin, Cesar Kenaan, Haoming Zhang, Paul F. Hollenberg

Publikováno v: Drug Metabolism and Disposition. 44:1771-1779

The crystal structures of human CYP2B6 indicate that Phe206 and Val367 are in close proximity to the substrate binding site and suggest that both residues may play important roles in substrate metabolism and inhibitor binding. To test this hypothesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027321ac8b36141187db806f4df3fd04
https://doi.org/10.1124/dmd.116.071662

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The Effect of Ritonavir on Human CYP2B6 Catalytic Activity: Heme Modification Contributes to the Mechanism-Based Inactivation of CYP2B6 and CYP3A4 by Ritonavir

Autor: Paul F. Hollenberg, Hsia Lien Lin, Cesar Kenaan, Diane M. Calinski, Jaime D’Agostino

Publikováno v: Drug Metabolism and Disposition. 41:1813-1824

The mechanism-based inactivation of human CYP2B6 by ritonavir (RTV) in a reconstituted system was investigated. The inactivation is time, concentration, and NADPH dependent and exhibits a K(I) of 0.9 μM, a k(inact) of 0.05 min⁻¹, and a partition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222d0239c8534c0f80e362e117454fcd
https://doi.org/10.1124/dmd.113.053108

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Reaction of Human Cytochrome P450 3A4 with Peroxynitrite: Nitrotyrosine Formation on the Proximal Side Impairs Its Interaction with NADPH-Cytochrome P450 Reductase

Autor: Haoming Zhang, Hsia Lien Lin, Cesar Kenaan, Paul F. Hollenberg

Publikováno v: Chemical Research in Toxicology. 25:2642-2653

The reaction of peroxynitrite (PN) with purified human cytochrome P450 3A4 (CYP3A4) resulted in the loss of the reduced-CO difference spectrum, but the absolute absorption spectrum of the heme was not significantly altered. The loss of 7-benzyloxy-4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9b320026e7596b5080469dbe92fa13
https://doi.org/10.1021/tx3002753

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Interactions between CYP2E1 and CYP2B4: Effects on Affinity for NADPH-Cytochrome P450 Reductase and Substrate Metabolism

Autor: Matthew Pratt-Hyatt, Haoming Zhang, Cesar Kenaan, Erin V. Shea, Hsia Lien Lin, Paul F. Hollenberg

Publikováno v: Drug Metabolism and Disposition. 41:101-110

Studies in microsomal and reconstituted systems have shown that the presence of one cytochrome P450 isoform can significantly influence the catalytic activity of another isoform. In this study, we assessed whether CYP2E1 could influence the catalytic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2a06797eca9a30d2d228a744f839b8
https://doi.org/10.1124/dmd.112.046094

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Identification of the Residue in Human CYP3A4 That Is Covalently Modified by Bergamottin and the Reactive Intermediate That Contributes to the Grapefruit Juice Effect

Autor: Hsia Lien Lin, Paul F. Hollenberg, Cesar Kenaan

Publikováno v: Drug Metabolism and Disposition. 40:998-1006

Previous studies have demonstrated that bergamottin (BG), a component of grapefruit juice, is a mechanism-based inactivator of CYP3A4 and contributes, in part, to the grapefruit juice-drug interaction. Although the covalent binding of [(14)C]BG to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea4bb350d86131c71d04e18918fa261
https://doi.org/10.1124/dmd.112.044560

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Covalent Modification of Thr302 in Cytochrome P450 2B1 by the Mechanism-Based Inactivator 4-tert-Butylphenylacetylene

Autor: Paul F. Hollenberg, Hsia Lien Lin, Monica I. Jushchyshyn, Haoming Zhang

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 333:663-669

The mechanism of inactivation of cytochrome P450 2B1 (CYP2B1) by 4-tert-butylphenylacetylene (BPA) has been characterized previously to be caused by the covalent binding of a reactive intermediate to the apoprotein rather than heme destruction (J Pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32b1719cfb18ddf20c399430e2e9095
https://doi.org/10.1124/jpet.109.164350

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tert-Butylphenylacetylene Is a Potent Mechanism-Based Inactivator of Cytochrome P450 2B4: Inhibition of Cytochrome P450 Catalysis by Steric Hindrance

Autor: Hsia Lien Lin, Djemel Hamdane, Haoming Zhang, Paul F. Hollenberg, Vyvyca J. Walker

Publikováno v: Molecular Pharmacology. 76:1011-1018

We have demonstrated that 4-(tert-butyl)-phenylacetylene (tBPA) is a potent mechanism-based inactivator for cytochrome P450 2B4 (P450 2B4) in the reconstituted system. It inactivates P450 2B4 in a NADPH- and time-dependent manner with a K(I) of 0.44

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f9f144b1a24dc68462b46ee956f7a3
https://doi.org/10.1124/mol.109.059808

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Mechanism-Based Inactivation of CYP2B1 and Its F-Helix Mutant by Twotert-Butyl Acetylenic Compounds: Covalent Modification of Prosthetic Heme Versus Apoprotein

Autor: Hsia Lien Lin, Kathleen R. Noon, Paul F. Hollenberg, Haoming Zhang

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 331:392-403

The mechanism-based inactivation of cytochrome CYP2B1 [wild type (WT)] and its Thr205 to Ala mutant (T205A) by tert-butylphenylacetylene (BPA) and tert-butyl 1-methyl-2-propynyl ether (BMP) in the reconstituted system was investigated. The inactivati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c0153277b1c61fcf801f96be78d37d
https://doi.org/10.1124/jpet.109.158782

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