Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hsi-Wen Yeh"'
Autor:
Yaw-Dong Lang, Hsin-Yi Chen, Chun-Ming Ho, Jou-Ho Shih, En-Chi Hsu, Roger Shen, Yu-Ching Lee, Jyun-Wei Chen, Cheng-Yen Wu, Hsi-Wen Yeh, Ruey-Hwa Chen, Yuh-Shan Jou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
PSPC1 has a critical role in promoting EMT and metastasis. Here, the authors demonstrate that PSPC1 is the contextual determinant of the oncogenic switch of PTK6/β-catenin subcellular localizations to drive metastasis of hepatocellular carcinoma cel
Externí odkaz:
https://doaj.org/article/6ae4243b31584b1da82d9909f2146f87
Autor:
Hsi-Wen Yeh, Yuh-Shan Jou
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
Metastatic reprogramming toward malignant tumor progression relies on the activation of oncogenic regulators, yet the cellular determinants remain elucidated. Through identification of aberrant prognostic cancer genes, we identified paraspeckle compo
Externí odkaz:
https://doaj.org/article/61870535f10242abbb3bd669eb4a4a1d
SUMMARYIron is the most abundant transition metal in cells and essential for a wide range of biochemical processes. While most mammalian cells take up iron through receptor-mediated endocytosis of transferrin, molecular players involved in iron utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad7f5645e4339f16d9c3be868a021e4
https://doi.org/10.1101/2022.02.06.479330
https://doi.org/10.1101/2022.02.06.479330
Autor:
Yuyang Liu, Michael G. Kharas, Benjamin Allwein, Frederick S. Yen, Xiphias Ge Zhu, Richard K Hite, Rebecca C. Timson, Eric R. Gamazon, Kıvanç Birsoy, Ying Wang, Søren Heissel, Hanzhi Luo, Ross A. Weber, Gokhan Unlu, Changrui Xing, Hsi-Wen Yeh
SUMMARYGlutathione (GSH) is a small molecule thiol abundantly present in all eukaryotes with key roles in oxidative metabolism1. Mitochondria, as the major site of oxidative reactions, must maintain sufficient levels of GSH to perform protective and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c591d924dd82e847cd19ea2930035b00
https://doi.org/10.1101/2021.09.15.460381
https://doi.org/10.1101/2021.09.15.460381
Autor:
En-Chi Hsu, Hsin Yi Chen, Yu Ching Lee, Chun Ming Ho, Roger Shen, Hsi Wen Yeh, Yuh-Shan Jou, Jyun Wei Chen, Jou Ho Shih, Ruey-Hwa Chen, Yaw Dong Lang, Cheng Yen Wu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to metastasis. Paraspeckle component 1 (PSPC1) upregulation has been identified as an HCC pro-metastatic activator associated with poor patient prognosis, but with a lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9746fdda0a76c43120dbfb822121898e
https://doaj.org/article/6ae4243b31584b1da82d9909f2146f87
https://doaj.org/article/6ae4243b31584b1da82d9909f2146f87
Autor:
Ying, Wang, Frederick S, Yen, Xiphias Ge, Zhu, Rebecca C, Timson, Ross, Weber, Changrui, Xing, Yuyang, Liu, Benjamin, Allwein, Hanzhi, Luo, Hsi-Wen, Yeh, Søren, Heissel, Gokhan, Unlu, Eric R, Gamazon, Michael G, Kharas, Richard, Hite, Kıvanç, Birsoy
Publikováno v:
Nature. 599(7883)
Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key roles in oxidative metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8df3a2e292b32c4003c7dfdc2808304a
https://pubmed.ncbi.nlm.nih.gov/34707288
https://pubmed.ncbi.nlm.nih.gov/34707288
Publikováno v:
Oncotarget
// Hsi-Wen Yeh 1, 2 , Szu-Shuo Lee 2, 3 , Chieh-Yu Chang 2, 4 , Chun-Mei Hu 5 and Yuh-Shan Jou 1, 2, 3, 4 1 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan 2 Institute of Biomedical Sciences, Academia Sinica, Taip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774ffe224b7dbe73a51f9dd826171149
https://doi.org/10.18632/oncotarget.20774
https://doi.org/10.18632/oncotarget.20774
Autor:
Yuh-Shan Jou, Hsi-Wen Yeh
Publikováno v:
Molecular & Cellular Oncology
Metastatic reprogramming toward malignant tumor progression relies on the activation of oncogenic regulators, yet the cellular determinants remain elucidated. Through identification of aberrant prognostic cancer genes, we identified paraspeckle compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96761092ad64e1407e9e9540ef1cd55f
http://europepmc.org/articles/PMC6149759
http://europepmc.org/articles/PMC6149759
Publikováno v:
Cancer research. 79(15)
The TGFβ cytokine plays dichotomous roles during tumor progression. In normal and premalignant cancer cells, the TGFβ signaling pathway inhibits proliferation and promotes cell-cycle arrest and apoptosis. However, the activation of this pathway in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64afa75c5af63c026c6ffe870ebb14df
https://pubmed.ncbi.nlm.nih.gov/31300476
https://pubmed.ncbi.nlm.nih.gov/31300476
Autor:
Chiung-Tong Chen, Suz Yi Lee, Hsi Wen Yeh, Pang-Hsien Tu, Yuh Charn Lin, Ruey-Bing Yang, Yuh-Shan Jou, De Leung Gu, Jou Ho Shih, Chun Ming Ho, En-Chi Hsu, Ching-Feng Cheng, Chieh-Yu Chang, Chian Feng Chen, Szu Shuo Lee, Ruey-Hwa Chen, Yaw Dong Lang
Publikováno v:
Nature cell biology. 20(4)
Activation of metastatic reprogramming is critical for tumour metastasis. However, more detailed knowledge of the underlying mechanism is needed to enable targeted intervention. Here, we show that paraspeckle component 1 (PSPC1), identified in an abe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d6c95c31403c80013afaa22ce95a61
https://pubmed.ncbi.nlm.nih.gov/29593320
https://pubmed.ncbi.nlm.nih.gov/29593320