Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Hsi Lung Hsieh"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7303-7323 (2024)
Gastric inflammation-related disorders are commonly observed digestive system illnesses characterized by the activation of proinflammatory cytokines, particularly tumor necrosis factor-α (TNF-α). This results in the induction of cyclooxygenase-2 (C
Externí odkaz:
https://doaj.org/article/00e1a71f892649ffbe89e01ac5be1557
Autor:
Tsong-Hai Lee, Jiun-Liang Chen, Chuan-Hsin Chang, Ming-Ming Tsai, Hui-Ching Tseng, Yu-Chia Chang, Velayuthaprabhu Shanmugam, Hsi-Lung Hsieh
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 226 (2024)
Matrix metalloproteinases (MMPs), which are proteolytic enzymes, promote blood–brain barrier (BBB) disruption, leading to neuronal damage and neuroinflammation. Among them, MMP-9 upregulation serves as an inflammatory biomarker in the central nervo
Externí odkaz:
https://doaj.org/article/c86918f515ad4af184d9f15b45eb9dfc
Autor:
Hsi-Lung Hsieh, Ching-Chung Liang, Cheng-You Lu, Jen-Tsung Yang, Chiu-Yen Chung, Yu-Shien Ko, Tsong-Hai Lee
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract Background Intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA) is the standard treatment for acute ischemic stroke. Standard-dose rt-PA (0.9 mg/kg) is known to achieve good recanalization but carries a high bleedi
Externí odkaz:
https://doaj.org/article/7cc3d14182a44c89a0e98c48a0d6a439
Autor:
Yi-Hsuan Wu, Hsi-Lung Hsieh
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1816 (2023)
Bioenergetic mitochondrial dysfunction is a common feature of several diseases, including Alzheimer’s disease (AD), where redox imbalance also plays an important role in terms of disease development. AD is an age-related disease and begins many yea
Externí odkaz:
https://doaj.org/article/d1ccbcc658b74f2ca27c02b8c0dacfa3
Autor:
Tong-Hong Wang, Chin-Chuan Chen, Yann-Lii Leu, Yun-Shien Lee, Jang-Hau Lian, Hsi-Lung Hsieh, Chi-Yuan Chen
Publikováno v:
Journal of the Formosan Medical Association, Vol 120, Iss 9, Pp 1695-1705 (2021)
Background/purpose: Palbociclib is an FDA-approved cyclin-dependent kinase (CDK) 4/6 inhibitor that has been clinically proven to be effective in breast cancer. However, its use in oral cancer is not well researched. In this study, we investigated th
Externí odkaz:
https://doaj.org/article/daf17f6fac1b488ba297c9895c342afe
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-13 (2020)
Abstract Background Upregulation of matrix metalloproteinase-9 (MMP-9) has been indicated as one of the inflammatory biomarkers. In the central nervous system (CNS), the MMP-9 is induced by several proinflammatory mediators and participates in the CN
Externí odkaz:
https://doaj.org/article/8c2f87c6291941a7bfb19306457c5298
Autor:
Chun-Han Su, Yu-Chieh Cheng, Yu-Chia Chang, Ting-Hsuan Kung, Yu-Li Chen, Kuei-Hung Lai, Hsi-Lung Hsieh, Chun-Yu Chen, Tsong-Long Hwang, Yu-Liang Yang
Publikováno v:
Molecules, Vol 27, Iss 14, p 4462 (2022)
The fruit of Tetradium ruticarpum (TR) is commonly used in Chinese herbal medicine and it has known antiproliferative and antitumor activities, which can serve as a good source of functional ingredients. Although some antiproliferative compounds are
Externí odkaz:
https://doaj.org/article/fd9ad2808912465c820786b5445db72c
Autor:
Ming-Ming Tsai, Jiun-Liang Chen, Tsong-Hai Lee, Hsiuming Liu, Velayuthaprabhu Shanmugam, Hsi-Lung Hsieh
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1270 (2022)
In the central nervous system (CNS), the matrix metalloproteinase-9 (MMP-9) is induced by several factors and contributes to CNS disorders, including inflammation and neurodegeneration. Thus, the upregulation of MMP-9 has been considered to be an ind
Externí odkaz:
https://doaj.org/article/f1721fa148954bb9939888e558b3a1b5
Autor:
Yi-Hsuan Wu, Hsi-Lung Hsieh
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 923 (2022)
The heme oxygenase (HO) system is believed to be a crucial mechanism for the nervous system under stress conditions. HO degrades heme to carbon monoxide, iron, and biliverdin. These heme degradation products are involved in modulating cellular redox
Externí odkaz:
https://doaj.org/article/09d13cf88fea4230be30f3eb59926fc9
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
Zinc ions (Zn2+) are important messenger molecules involved in various physiological functions. To maintain the homeostasis of cytosolic Zn2+ concentration ([Zn2+]c), Zrt/Irt-related proteins (ZIPs) and Zn2+ transporters (ZnTs) are the two families o
Externí odkaz:
https://doaj.org/article/451c58b86d08434a91773ab76f0359db