Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Hrvoje Augustin"'
Autor:
Virender K. Sahota, Aelfwin Stone, Nathaniel S. Woodling, Jereme G. Spiers, Joern R. Steinert, Linda Partridge, Hrvoje Augustin
Publikováno v:
Open Biology, Vol 13, Iss 9 (2023)
Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function. Mammalian Myostatin (MST) and GDF11, members of the TGF-β sup
Externí odkaz:
https://doaj.org/article/52604fc9b84246b693fbae8899b28894
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Neurodegenerative diseases are a large class of neurological disorders characterized by progressive dysfunction and death of neurones. Examples include Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, and amyotrophic lateral scl
Externí odkaz:
https://doaj.org/article/9bb10e7750b9401085f8a3990a58915b
Autor:
Ella Dunn, Joern R. Steinert, Aelfwin Stone, Virender Sahota, Robin S. B. Williams, Stuart Snowden, Hrvoje Augustin
Publikováno v:
Cells, Vol 12, Iss 17, p 2163 (2023)
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterised by progressive degeneration of the motor neurones. An expanded GGGGCC (G4C2) hexanucleotide repeat in C9orf72 is the most common genetic cause of ALS and fr
Externí odkaz:
https://doaj.org/article/e183861f2de04cafaf6c2fb2b7866f6d
Publikováno v:
Fly, Vol 11, Iss 4, Pp 284-289 (2017)
Myoglianin, the Drosophila homolog of the secreted vertebrate proteins Myostatin and GDF-11, is an important regulator of neuronal modeling, and synapse function and morphology. While Myoglianin suppression during development elicits positive effects
Externí odkaz:
https://doaj.org/article/faf0418533934f47a6042cea668f3e96
Autor:
Hrvoje Augustin, Kieran McGourty, Marcus J Allen, Sirisha Kudumala Madem, Jennifer Adcott, Fiona Kerr, Chi Tung Wong, Alec Vincent, Tanja Godenschwege, Emmanuel Boucrot, Linda Partridge
Publikováno v:
PLoS Biology, Vol 15, Iss 9, p e2001655 (2017)
Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox"). Chronic, moderately lowered IIS rescues age-related decline in neuro
Externí odkaz:
https://doaj.org/article/86acefcd2570465f95e24b7ce6e9926a
Autor:
Oyinkan Sofola, Fiona Kerr, Iain Rogers, Richard Killick, Hrvoje Augustin, Carina Gandy, Marcus J. Allen, John Hardy, Simon Lovestone, Linda Partridge
Publikováno v:
PLoS Genetics, Vol 8, Iss 1 (2012)
Externí odkaz:
https://doaj.org/article/16a1ca69836d4766b9b97ac568fe6722
Autor:
Oyinkan Sofola, Fiona Kerr, Iain Rogers, Richard Killick, Hrvoje Augustin, Carina Gandy, Marcus J Allen, John Hardy, Simon Lovestone, Linda Partridge
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001087 (2010)
Abeta peptide accumulation is thought to be the primary event in the pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the hyperphosphorylation of tau protein. Glycogen synthase kinase-3 (GSK-3) is increasingly im
Externí odkaz:
https://doaj.org/article/0e6a562315624a738a2ab43409631170
Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function. Mammalian Myostatin (MST) and GDF11, members of the TGF-β sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9b13a186a77661b06790d0dd830bcb
https://doi.org/10.1101/463885
https://doi.org/10.1101/463885
Publikováno v:
eNeuro
The Giant Fiber System (GFS) is a multi-component neuronal pathway mediating rapid escape response in the adult fruit-flyDrosophila melanogaster, usually in the face of a threatening visual stimulus. Two branches of the circuit promote the response b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4dfac87d881cfb9fbad8c8948f6f0a
https://doi.org/10.1101/435362
https://doi.org/10.1101/435362
Autor:
Marianna Karina Gorsky, Sylvie Burnouf, Oyinkan Sofola-Adesakin, Jacqueline Dols, Hrvoje Augustin, Carina Marianne Weigelt, Sebastian Grönke, Linda Partridge
Publikováno v:
Scientific Reports
Sci Rep
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Sci Rep
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Tau is a microtubule-associated protein that is highly soluble and natively unfolded. Its dysfunction is involved in the pathogenesis of several neurodegenerative disorders including Alzheimer’s disease (AD), where it aggregates within neurons. Dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c54139cd0f8763e497f9038226dcaf2e