Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In VivoEfficacy

Autor: Skudlarek, Jason W., Cooke, Andrew J., Mitchell, Helen J., Babaoglu, Kerim, Shaw, Anthony W., Tong, Ling, Nomland, Ashley B., Labroli, Marc, Sha, Deyou, Mulhearn, James J., Wu, Chengwei, Li, Sarah W., Beshore, Douglas C., Hughes, Jonathan M. E., Jouffroy, Matthieu, Wang, Hao, Balibar, Carl J., Painter, Ronald E., Shen, Pamela, Lange, Henry S., Ishchenko, Andrii, Chen, Yun-Ting, Klein, Daniel J., Tracy, Rodger W., Miller, Randy R., Cabalu, Tamara D., Wu, Zhe, Leithead, Andrew, Scapin, Giovanna, Hruza, Alan W., Dzhekieva, Liudmila, Bukhtiyarova, Marina, Homsher, Michelle F., Xu, Min, Bahnck-Teets, Carolyn, McKenney, David, Buevich, Alexei V., Liu, Jian, Zhang, Li-Kang, Meng, Tao, Kelly, Terri, DiNunzio, Edward, Soisson, Stephen, Cheng, Robert K. Y., Hennig, Michael, Raheem, Izzat, Walker, Scott S.

Publikováno v: Journal of Medicinal Chemistry; September 2024, Vol. 67 Issue: 17 p15620-15675, 56p

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Discovery of Novel, Dual MechanismERK Inhibitorsby Affinity Selection Screening of an Inactive Kinase.

Autor: Deng, Yongqi, Shipps, Gerald W., Cooper, Alan, English, Jessie M., Annis, D. Allen, Carr, Donna, Nan, Yang, Wang, Tong, Zhu, Hugh Y., Chuang, Cheng-Chi, Dayananth, Priya, Hruza, Alan W., Xiao, Li, Jin, Weihong, Kirschmeier, Paul, Windsor, William T., Samatar, Ahmed A.

Publikováno v: Journal of Medicinal Chemistry; Nov2014, Vol. 57 Issue 21, p8817-8826, 10p

Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.

Autor: Bukhtiyarova M; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Cook EM; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Hancock PJ; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Hruza AW; MRL, Merck & Co., Inc., Kenilworth, New Jersey, 07033, United States., Shaw AW; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Adam GC; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Barnard RJO; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., McKenna PM; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Holloway MK; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Bell IM; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Carroll S; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Cornella-Taracido I; MRL, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Cox CD; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kutchukian PS; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Powell DA; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Strickland C; MRL, Merck & Co., Inc., Kenilworth, New Jersey, 07033, United States., Trotter BW; MRL, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Tudor M; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Wolkenberg S; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Li J; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Tellers DM; MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Dec 23; Vol. 12 (1), pp. 99-106. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2021).