Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hristina Gapeshina"'
Autor:
Ghazaleh Eskandari-Sedighi, Nathalie Daude, Hristina Gapeshina, David W. Sanders, Razieh Kamali-Jamil, Jing Yang, Beipei Shi, Holger Wille, Bernardino Ghetti, Marc I. Diamond, Christopher Janus, David Westaway
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-27 (2017)
Abstract Background MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical phenotypes. Methods Given heterogeneities observed in a transgenic (Tg) m
Externí odkaz:
https://doaj.org/article/ad802f1a591b45aea72e7e7ffc41bd03
Autor:
Robert C C Mercer, Nathalie Daude, Lyudmyla Dorosh, Ze-Lin Fu, Charles E Mays, Hristina Gapeshina, Serene L Wohlgemuth, Claudia Y Acevedo-Morantes, Jing Yang, Neil R Cashman, Michael B Coulthart, Dawn M Pearson, Jeffrey T Joseph, Holger Wille, Jiri G Safar, Gerard H Jansen, Maria Stepanova, Brian D Sykes, David Westaway
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006826 (2018)
To explore pathogenesis in a young Gerstmann-Sträussler-Scheinker Disease (GSS) patient, the corresponding mutation, an eight-residue duplication in the hydrophobic region (HR), was inserted into the wild type mouse PrP gene. Transgenic (Tg) mouse l
Externí odkaz:
https://doaj.org/article/a81806809d1741fdbe1f6cd4fbdb15ec
Autor:
Agnes Lau, Alex McDonald, Nathalie Daude, Charles E Mays, Eric D Walter, Robin Aglietti, Robert CC Mercer, Serene Wohlgemuth, Jacques van derMerwe, Jing Yang, Hristina Gapeshina, Chae Kim, Jennifer Grams, Beipei Shi, Holger Wille, Aru Balachandran, Gerold Schmitt‐Ulms, Jiri G Safar, Glenn L Millhauser, David Westaway
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 3, Pp 339-356 (2015)
Abstract The cellular prion protein (PrPC) comprises a natively unstructured N‐terminal domain, including a metal‐binding octarepeat region (OR) and a linker, followed by a C‐terminal domain that misfolds to form PrPSc in Creutzfeldt‐Jakob di
Externí odkaz:
https://doaj.org/article/5e77529f4279415d8aa0b5975d382b3d
Autor:
Nathalie Daude, Inyoul Lee, Taek-Kyun Kim, Christopher Janus, John Paul Glaves, Hristina Gapeshina, Jing Yang, Brian D Sykes, George A Carlson, Leroy E Hood, David Westaway
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149410 (2016)
Pituitary Prolactin (PRL) and Growth Hormone (GH) are separately controlled and sub-serve different purposes. Surprisingly, we demonstrate that extra-pituitary expression in the adult mammalian central nervous system (CNS) is coordinated at mRNA and
Externí odkaz:
https://doaj.org/article/dfb3519b1b0a4b96a78cfdb047547dec
Autor:
Nathalie Daude, David Westaway, Christopher Janus, Marc I. Diamond, David W. Sanders, Holger Wille, Hristina Gapeshina, Ghazaleh Eskandari-Sedighi, Bernardino Ghetti, Jing Yang, Beipei Shi, Razieh Kamali-Jamil
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-27 (2017)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical phenotypes. Methods Given heterogeneities observed in a transgenic (Tg) mouse line
Autor:
Holger Wille, David Westaway, Robert C.C. Mercer, Ze-Lin Fu, Charles E. Mays, Dawn Pearson, Jing Yang, Nathalie Daude, Maria Stepanova, Jiri G. Safar, Serene Wohlgemuth, Lyudmyla Dorosh, Jeffrey T. Joseph, Brian D. Sykes, Michael B. Coulthart, Gerard H. Jansen, Neil R. Cashman, Claudia Y Acevedo-Morantes, Hristina Gapeshina
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006826 (2018)
PLoS Pathogens
PLoS Pathogens
To explore pathogenesis in a young Gerstmann-Sträussler-Scheinker Disease (GSS) patient, the corresponding mutation, an eight-residue duplication in the hydrophobic region (HR), was inserted into the wild type mouse PrP gene. Transgenic (Tg) mouse l
Autor:
Robin A. Aglietti, Robert C.C. Mercer, Agnes Lau, Glenn L. Millhauser, Serene Wohlgemuth, Gerold Schmitt-Ulms, David Westaway, Hristina Gapeshina, Charles E. Mays, Chae Kim, Jing Yang, Jennifer Grams, Beipei Shi, Holger Wille, Nathalie Daude, Aru Balachandran, Eric D. Walter, Jiri G. Safar, Alex J. McDonald, Jacques van der Merwe
Publikováno v:
EMBO Molecular Medicine
ResearcherID
ResearcherID
The cellular prion protein (PrP(C)) comprises a natively unstructured N-terminal domain, including a metal-binding octarepeat region (OR) and a linker, followed by a C-terminal domain that misfolds to form PrP(S) (c) in Creutzfeldt-Jakob disease. PrP
Autor:
Christopher Janus, Taek-Kyun Kim, Jing Yang, George A. Carlson, Brian D. Sykes, Leroy Hood, Inyoul Lee, Nathalie Daude, Hristina Gapeshina, John Paul Glaves, David Westaway
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149410 (2016)
PLoS ONE
PLoS ONE
Pituitary Prolactin (PRL) and Growth Hormone (GH) are separately controlled and sub-serve different purposes. Surprisingly, we demonstrate that extra-pituitary expression in the adult mammalian central nervous system (CNS) is coordinated at mRNA and
Publikováno v:
Prion
Biochemical similarities have been noted between the natively unstructured region of the cellular prion protein, PrP(C), and a GPI-linked glycoprotein called Shadoo (Sho); these proteins are encoded by the Prnp and Sprn genes, respectively. Both prot
Autor:
Hristina Gapeshina, Rose Pitstick, Serene Wohlgemuth, David Westaway, Nathalie Daude, George A. Carlson, Rebecca S. H. Brown, Jing Yang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(23)
The Sprn gene encodes Shadoo (Sho), a glycoprotein with biochemical properties similar to the unstructured region of cellular prion protein (PrP C ). Sho has been considered a candidate for the hypothetical π protein that supplies a PrP C -like func