Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Hriday K. Das"'
Autor:
Hriday K. Das, Silahis S. Hontiveros
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 25, Iss 6, Pp 1172-1183 (2020)
Presenilin-1 (PS1) protein is the catalytic subunit of the gamma-secretase, and participates in the processing of beta-amyloid precursor protein (APP) to produce Abeta peptide and Notch 1 receptor to release Notch intracellular domain (NICD) in the c
Externí odkaz:
https://doaj.org/article/ef18012fcb0c4903818491805aafa4f9
Autor:
Hriday K. Das, Silahis S. Hontiveros
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 25, Iss 7, Pp 1297-1304 (2020)
Presenilin-1 (PS1) is the catalytic subunit of gamma-secretase. PS1 cleaves beta-amyloid precursor protein (APP) to produce Abeta peptide and Notch 1 receptor to release Notch intracellular domain (NICD) in the cytoplasm. We have previously shown tha
Externí odkaz:
https://doaj.org/article/69a78bf09b3847aa9cc2877a401c717b
Autor:
Imran Hussain, Paromita Deb, Avisankar Chini, Monira Obaid, Arunoday Bhan, Khairul I. Ansari, Bibhu P. Mishra, Samara A. Bobzean, S. M. Nashir Udden, Prasanna G. Alluri, Hriday K. Das, Robert Matthew Brothers, Linda I. Perrotti, Subhrangsu S. Mandal
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
HOXA5 is a homeobox-containing gene associated with the development of the lung, gastrointestinal tract, and vertebrae. Here, we investigate potential roles and the gene regulatory mechanism in HOXA5 in breast cancer cells. Our studies demonstrate th
Externí odkaz:
https://doaj.org/article/b9d54136e1b64b4292b1e464684dda9c
Autor:
Silahis S Hontiveros, Hriday K. Das
Publikováno v:
Frontiers in Bioscience. 25:1297-1304
Presenilin-1 (PS1) is the catalytic subunit of gamma-secretase. PS1 cleaves beta-amyloid precursor protein (APP) to produce Abeta peptide and Notch 1 receptor to release Notch intracellular domain (NICD) in the cytoplasm. We have previously shown tha
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 358:516-526
Presenilin-1 (PS1) is a core component of γ-secretase that is involved in neurodegeneration. We have previously shown that PS1 interacts with a mitogen-activated protein kinase [(MAPK) jun-NH2-terminal-kinase], and another MAPK (p38) is activated by
Autor:
Divya Duggal, Vipulkumar Patel, Ignacy Gryczynski, Kenneth S. Campbell, Julian Borejdo, Zygmunt Gryczynski, Ryan Rich, Sebastian Requena, Cheavar A. Blair, Rafal Fudala, Janhavi Nagwekar, Sangram Raut, Hriday K. Das
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Frontiers in Physiology
Frontiers in Physiology
The systemic circulation offers larger resistance to the blood flow than the pulmonary system. Consequently, the left ventricle (LV) must pump blood with more force than the right ventricle (RV). The question arises whether the stronger pumping actio
Publikováno v:
Journal of Neurochemistry. 122:487-500
J. Neurochem. (2012) 122, 487–500. Abstract Genetic deletion or mutations of presenilin genes (PS1/PS2) cause familial Alzheimer’s disease and calcium (Ca2+) signaling abnormalities. PS1/PS2 act as endoplasmic reticulum (ER) Ca2+ leak channels th
Autor:
Zygmunt Gryczynski, Ignacy Gryczynski, Krishna Midde, Julian Borejdo, Hriday K. Das, V. Dumka, Rafal Luchowski, J. Fedorick
Publikováno v:
Biophysical Journal. 100:1024-1033
We examined the orientational fluctuations of a small number of myosin molecules (approximately three) in working skeletal muscle myofibrils. Myosin light chain 1 (LC1) was labeled with a fluorescent dye and exchanged with the native LC1 of skeletal
Autor:
Sebum Lee, Hriday K. Das
Publikováno v:
Frontiers in Bioscience. :22-35
Inhibition of basal JNK activity by JNK inhibitor SP600125 or JNK1siRNA repressed presenilin-1 (PS1) expression in SK-N-SH cells by augmenting the level of p53, a repressor of the PS1 gene (1). We now showed that repression of PS1 transcription by JN
Publikováno v:
FEBS Journal. 276:3299-3307
Mixed lineage leukemias (MLLs) are histone-methylating enzymes with critical roles in gene expression, epigenetics and cancer. Although MLLs are important gene regulators little is known about their own regulation. Herein, to understand the effects o