Výsledky vyhledávání - "Hrib, Nicholas J."

Benzisoxazole- and Benzisothiazole-3-carboxamides as Potential Atypical Antipsychotic Agents

Autor: Paul G. Conway, Joachim E. Roehr, Kendra L. Burgher, Jurcak John G, L. L. Kerman, Harold B. Hartman, Hrib Nicholas J, Woods Ann Theresa

Publikováno v: Journal of Medicinal Chemistry. 37:2308-2314

A series of benzisoxaazole- and benzisothiazole-3-carboxamides has been prepared and tested for potential antipsychotic activity. In general, the compounds showed an affinity for dopamine D 2 and serotonin 5HT 2A and 5HT 1A receptors. Several members

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c19b10bad7a6db7d13bbed8e553a51f
https://doi.org/10.1021/jm00041a009

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ChemInform Abstract: Benzisoxazole- and Benzisothiazole-3-carboxamides as Potential Atypical Antipsychotic Agents

Autor: Paul G. Conway, Joachim E. Roehr, Hrib Nicholas J, L. L. Kerman, Kendra L. Burgher, Jurcak John G, Woods Ann Theresa, Harold B. Hartman

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02112b01fc223667afdc88ea96b60e59
https://doi.org/10.1002/chin.199451169

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ChemInform Abstract: Structure-Activity Relationships of a Series of Novel ( Piperazinylbutyl)thiazolidinone Antipsychotic Agents Related to 3-(4-( 4-(6-Fluorobenzo(b)thien-3-yl)-1-piperazinyl)butyl)-2,5,5-trimethyl-4- thiazolidinone Maleate

Autor: Mark R. Szewczak, H. B. Hartmann, S. Kongsamut, L. L. Kerman, A. T. Woods-Kettelberger, R. Corbett, Kendra L. Burgher, Jurcak John G, Hrib Nicholas J, D. E. Bregna, Joachim E. Roehr, S. Kafka

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d852ddf2afb7063c3006d371c15674ab
https://doi.org/10.1002/chin.199704180

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Chemoinformatics: are we exploiting this new science?

Autor: Norton P. Peet, Hrib Nicholas J

Publikováno v: Drug Discovery Today. 5:483-485

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89ba503d35c1a6fed23a1b3b4b996bf0
https://doi.org/10.1016/s1359-6446(00)01560-9

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Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents

Autor: Robert W. Dunn, Cheri L. Errico, Jurcak John G, Francis P. Huger, Hrib Nicholas J

Publikováno v: Journal of Medicinal Chemistry. 34:1068-1072

In a continuing proram to discover antipsychotic agents with a reduced propensity toward extrapyramidal side-effects, a series of N-alkoxyimides and -amides was prepared. Evaluation of these compounds in vitro revealed affinities for D 2 , 5HT 2 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d68f1f87999e4cbd390fa9ece67d42a
https://doi.org/10.1021/jm00107a028

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Aminopyridine carbamic acid esters: synthesis and potential as acetylcholinesterase inhibitors and acetylcholine releasers

Autor: Francis P. Huger, Gregory M. Shutske, Jurcak John G, Hrib Nicholas J, Kevin J. Kapples, Craig P. Smith, John Dick Tomer, Gina M. Bores, Wayne W. Petko

Publikováno v: Journal of pharmaceutical sciences. 81(4)

4-Amino-3-pyridyl carbamates (2a-c) were synthesized as potential acetylcholinesterase inhibitors and acetylcholine releasers on the basis of the reported activity of the analogous N-(4-amino-3-pyridyl)-N',N'-dimethylurea (1). Although 4-amino-3-pyri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c370bebfd56923669d6b90045af0e2d
https://pubmed.ncbi.nlm.nih.gov/1501077

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