Zobrazeno 1 - 2
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pro vyhledávání: '"Hrd1p ubiquitin ligase complex"'
Autor:
Lynne M. Roberts, Shuyu Li, Graham Ladds, Stuart C H Allen, Tina Schnöder, Robert A. Spooner, Manfred J. Schmitt, Christopher P. Guise, J. Michael Lord
Publikováno v:
Molecular Biology of the Cell
This study reveals that components of the yeast ERAD-L pathway can discriminate between two subtly different forms of the same toxin substrate. Although precytosolic requirements are similar for both toxin structures, there is a divergence in fate on
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41119 (2012)
PLoS ONE
PLoS ONE
Background\ud Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes. Currently, no molecular de