Harnessing transcriptomic signals for amyotrophic lateral sclerosis to identify novel drugs and enhance risk prediction

Autor: Oliver Pain, Ashley Jones, Ahmad Al Khleifat, Devika Agarwal, Dzmitry Hramyka, Hajer Karoui, Jędrzej Kubica, David J. Llewellyn, Janice M. Ranson, Zhi Yao, Alfredo Iacoangeli, Ammar Al-Chalabi

Publikováno v: Heliyon, Vol 10, Iss 15, Pp e35342- (2024)

Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. This study integrates common genetic association results from the latest ALS genome-wide association study (GWAS) summary statistics with functional genomic annot

Externí odkaz: https://doaj.org/article/64bff13ca9804855b263f30beafbdc37

Machine Learning and External Validation of the IDENTIFY Risk Calculator for Patients with Haematuria Referred to Secondary Care for Suspected Urinary Tract Cancer

Autor: Orecchia, Luca, Tijerina, Adan, Simoes, Adrian, Ali, Ahmed, Nic an Riogh, Aisling, Wong, Albert, Kiciak, Alex, Ridgway, Alexander, Szostek, Alexandra, Dhanasekaran, Ananda, Cheong, Anderson, Atayi, Andrew, Ashpak, Ashna, Gutierrez Hidalgo, Beatriz, Teixeira, Bernardo, Maria Scornajenghi, Carlo, Marramaque, Carolina, Reynoldson, Charmian, Ho Chee Kong, Christopher, Crewe, Claire, Griffiths, Daniel, Amporore, Daniele, Mak, David, Sarkar, Debashis, Chung Wei Ling, Desmond, Bheenick, Divya, Hogan, Donnacha, Orakwe, Dubem, Gordon, Emma, Checcucci, Enrico, Nawaz, Faisal, Ribeiro Gonçalves, Fernando, Lozano Palacio, Fernando, Prata, Francesco, Claps, Francesco, Del Giudice, Francesco, Aggarwal, Gaurav, Marcq, Gautier, Hatzichristodoulou, Georgios, Karagiannidis, Georgios, Maria Pirola, Giacomo, Russo, Giorgio, Hytham, Hamid, Chun Khoo, Hau, Abozied, Hesham, Patel, Hiten D., Colvin, Holly, Ali, Iftikhar, Chibuzo, Ijeoma, Fakhradiyev, Ildar, Sokolakis, Ioannis, Tsikopoulos, Ioannis, Chong, James, Bondad, Jasper, Abbaraju, Jayasimha, Teoh, Jeremy, Whitburn, Jessica, Hayes, John, Luis Bauza Quetglas, Jose, Antonio Herranz Yague, Jose, Gomez Rivas, Juan, Colombo Stenstrom, Juan, de Mello, Kathryn Bandeira, Brodie, Katie, Tzelves, Lazaros, Lazaros, Lazarou, Paramore, Louise, Rico, Luis, Lilis, Lydia, Ullmann, Maha, Srour, Mahmoud, Boltri, Matteo, Mustafa, Mohamed, Eyad Takahji, Mohammad, Almusimie, Mohammed, Shakeel Inder, Mohammud, Elgamal, Mostafa, Misurati, Muftah, Ali, Muhammad-Kabir, Binnawara, Muhannud, Bhaloo, Nabeela, Vidal Crespo, Natalia, Ernesto Morales Palacios, Nelson, Santoni, Nicola, Pyrgidis, Nikolaos, Hamilton, Olivia, Abad Lopez, Pablo, Maheshkumar, Pattabiraman, Sountoulides, Petros, Piazza, Pietro, Moreno, Pilar, Sarmah, Piyush, Narayan, Prabhat, Banthia, Ravi, Matulewicz, Richard, Contieri, Roberto, David, Rotimi, Mohammad, Sabir, Abu, Sadiq, Alonso, Santiago, Ippoliti, Simona, Weber, Stephan, Abuhasanein, Suleiman, Lee, Taeweon, Klatte, Tobias, Trung Thanh, Tran, Wazir, Usman, Ulker, Volkan, Yeoh, W.S., Feuer, Zach, Elahi, Zain, Gall, Zara, Khadhouri, Sinan, Hramyka, Artsiom, Gallagher, Kevin, Light, Alexander, Edison, Marie, Alexander, Cameron, Kulkarni, Meghana, Zimmermann, Eleanor, Nathan, Arjun, Tran, Trung-Thanh, Kelsey, Tom, Kasivisvanathan, Veeru

Publikováno v: In European Urology Focus June 2024

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Endocrine Requirements for Oocyte Maturation Following hCG, GnRH Agonist, and Kisspeptin During IVF Treatment

Autor: Ali Abbara, Tia Hunjan, Vu N. A. Ho, Sophie A. Clarke, Alexander N. Comninos, Chioma Izzi-Engbeaya, Tuong M. Ho, Geoffrey H. Trew, Artsiom Hramyka, Tom Kelsey, Rehan Salim, Peter Humaidan, Lan N. Vuong, Waljit S. Dhillo

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

ObjectiveThe maturation of oocytes to acquire competence for fertilization is critical to the success of in vitro fertilization (IVF) treatment. It requires LH-like exposure, provided by either human chorionic gonadotropin (hCG), or gonadotropin rele

Externí odkaz: https://doaj.org/article/f8dcef9b710144d0a710781b18111f27