Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Hraber, P"'
Autor:
Hraber, Peter, Korber, Bette, Wagh, Kshitij, Giorgi, Elena E., Bhattacharya, Tanmoy, Gnanakaran, S., Lapedes, Alan S., Learn, Gerald H., Kreider, Edward F., Li, Yingying, Shaw, George M., Hahn, Beatrice H., Montefiori, David C., Alam, S. Munir, Bonsignori, Mattia, Moody, M. Anthony, Liao, Hua-Xin, Gao, Feng, Haynes, Barton F.
Within-host genetic sequencing from samples collected over time provides a dynamic view of how viruses evade host immunity. Immune-driven mutations might stimulate neutralization breadth by selecting antibodies adapted to cycles of immune escape that
Externí odkaz:
http://arxiv.org/abs/1508.00463
Autor:
Hraber, Peter T., Korber, Bette T., Wolinsky, Steven, Erlich, Henry A., Trachtenberg, Elizabeth A., Kepler, Thomas B.
Publikováno v:
Lecture Notes in Computer Science Volume 4345, 2006, pp 1-12
The minimum description length (MDL) principle states that the best model to account for some data minimizes the sum of the lengths, in bits, of the descriptions of the model and the residual error. The description length is thus a criterion for mode
Externí odkaz:
http://arxiv.org/abs/q-bio/0505050
Autor:
Hongshuo Song, Elena E. Giorgi, Vitaly V. Ganusov, Fangping Cai, Gayathri Athreya, Hyejin Yoon, Oana Carja, Bhavna Hora, Peter Hraber, Ethan Romero-Severson, Chunlai Jiang, Xiaojun Li, Shuyi Wang, Hui Li, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Nilu Goonetilleke, Brandon F. Keele, David C. Montefiori, Myron S. Cohen, George M. Shaw, Beatrice H. Hahn, Andrew J. McMichael, Barton F. Haynes, Bette Korber, Tanmoy Bhattacharya, Feng Gao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Recombination contributes to HIV evolution in patients, but its identification can be difficult. Here, the authors develop a computational tool called RAPR to track recombination in patients, identify recombination hot spots, and show contribution of
Externí odkaz:
https://doaj.org/article/30d8c57d3c3f40a3b0cc066eb2a1b284
In this paper we review previous work and present new work concerning the relationship between dynamical systems theory and computation. In particular, we review work by Langton \cite{Langton90} and Packard \cite{Packard88} on the relationship betwee
Externí odkaz:
http://arxiv.org/abs/adap-org/9306003
We present results from an experiment similar to one performed by Packard (1988), in which a genetic algorithm is used to evolve cellular automata (CA) to perform a particular computational task. Packard examined the frequency of evolved CA rules as
Externí odkaz:
http://arxiv.org/abs/adap-org/9303003
Autor:
Zachary R. Stromberg, Will Fischer, Steven B. Bradfute, Jessica Z. Kubicek-Sutherland, Peter Hraber
Publikováno v:
Vaccines, Vol 8, Iss 2, p 273 (2020)
Vaccinations are a crucial intervention in combating infectious diseases. The three neurotropic Alphaviruses, Eastern (EEEV), Venezuelan (VEEV), and Western (WEEV) equine encephalitis viruses, are pathogens of interest for animal health, public healt
Externí odkaz:
https://doaj.org/article/bb89773858cd401281802fc99d12730d
Autor:
Kshitij Wagh, Edward F. Kreider, Yingying Li, Hannah J. Barbian, Gerald H. Learn, Elena Giorgi, Peter T. Hraber, Timothy G. Decker, Andrew G. Smith, Marcos V. Gondim, Lindsey Gillis, Jamie Wandzilak, Gwo-Yu Chuang, Reda Rawi, Fangping Cai, Pierre Pellegrino, Ian Williams, Julie Overbaugh, Feng Gao, Peter D. Kwong, Barton F. Haynes, George M. Shaw, Persephone Borrow, Michael S. Seaman, Beatrice H. Hahn, Bette Korber
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 893-908.e7 (2018)
Summary: Densely arranged N-linked glycans shield the HIV-1 envelope (Env) trimer from antibody recognition. Strain-specific breaches in this shield (glycan holes) can be targets of vaccine-induced neutralizing antibodies that lack breadth. To unders
Externí odkaz:
https://doaj.org/article/263741a4aea942aabfd534e4a17be6c2
Autor:
Sara D’Angelo, Fortunato Ferrara, Leslie Naranjo, M. Frank Erasmus, Peter Hraber, Andrew R. M. Bradbury
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Because of its great potential for diversity, the immunoglobulin heavy-chain complementarity-determining region 3 (HCDR3) is taken as an antibody molecule’s most important component in conferring binding activity and specificity. For this reason, H
Externí odkaz:
https://doaj.org/article/4aca73f2004c476eae6e3e06b8cae5fe
Publikováno v:
eLife, Vol 7 (2018)
HIV-1 Envelope (Env) variants are grouped into tiers by their neutralization-sensitivity phenotype. This helped to recognize that tier 1 neutralization responses can be elicited readily, but do not protect against new infections. Tier 3 viruses are t
Externí odkaz:
https://doaj.org/article/9e615c3c25fa4b1aa28b12279d5e4138
Autor:
Peter Hraber, Bette Korber, Kshitij Wagh, Elena E. Giorgi, Tanmoy Bhattacharya, S. Gnanakaran, Alan S. Lapedes, Gerald H. Learn, Edward F. Kreider, Yingying Li, George M. Shaw, Beatrice H. Hahn, David C. Montefiori, S. Munir Alam, Mattia Bonsignori, M. Anthony Moody, Hua-Xin Liao, Feng Gao, Barton F. Haynes
Publikováno v:
Viruses, Vol 7, Iss 10, Pp 5443-5475 (2015)
Within-host genetic sequencing from samples collected over time provides a dynamic view of how viruses evade host immunity. Immune-driven mutations might stimulate neutralization breadth by selecting antibodies adapted to cycles of immune escape that
Externí odkaz:
https://doaj.org/article/cefd2f81274f40d19b1c54ff5cc382fd