Zobrazeno 1 - 10
of 881
pro vyhledávání: '"Hp, Koeffler"'
Autor:
TW McLean, S Ringold, D Neuberg, K Stegmaier, R Tantravahi, J Ritz, HP Koeffler, S Takeuchi, JW Janssen, T Seriu, CR Bartram, SE Sallan, DG Gilliland, TR Golub
Publikováno v:
Blood. 88:4252-4258
Polymerase chain reaction-based screening of childhood acute lymphoblastic leukemia (ALL) samples showed that a TEL/AML1 fusion transcript was detected in 27% of all cases, representing the most common known gene rearrangement in childhood cancer. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c1e3f52274820409dae16346db1a33
https://doi.org/10.1182/blood.v88.11.4252.bloodjournal88114252
https://doi.org/10.1182/blood.v88.11.4252.bloodjournal88114252
Autor:
MI Dawson, R Morosetti, S Pakkala, W Chao, Hironori Ueno, Y. Ikeda, DL Chen, HP Koeffler, M Morikawa, M Pfahl, Masahiro Kizaki, E Elster, R Heyman, D Heber
Publikováno v:
Scopus-Elsevier
The biologic effects of retinoids such as all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid on proliferation and differentiation of hematopoietic cells are mediated by binding and activating two distinct families of transcription factors: the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107b232f2f2ed92388aafbaaecbf9bf4
https://doi.org/10.1182/blood.v87.5.1977.1977
https://doi.org/10.1182/blood.v87.5.1977.1977
Autor:
HP Koeffler, T Hirama
Publikováno v:
Blood. 86:841-854
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3866f442b8e65f514322ee4600bc06
https://doi.org/10.1182/blood.v86.3.841.bloodjournal863841
https://doi.org/10.1182/blood.v86.3.841.bloodjournal863841
Publikováno v:
Blood. 84:446-452
Retinoids, such as all-trans-retinoic acid and 9-cis-retinoic acid, are naturally occurring ligands of the nuclear retinoic acid receptors (RARs). In concert with binding of ligand, these receptors from heterodimers with the retinoic X receptor (RXR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f06d8bbf385b053d6ae6447798e51c3
https://doi.org/10.1182/blood.v84.2.446.bloodjournal842446
https://doi.org/10.1182/blood.v84.2.446.bloodjournal842446
Autor:
Hideaki Nakajima, Y. Ikeda, Masahiro Kizaki, HP Koeffler, Masaki Saito, M Ohta, Shigehisa Mori, M Morikawa, T Koike
Publikováno v:
Blood. 83:3289-3297
Recent studies have shown that a high proportion of patients with acute promyelocytic leukemia (APL) achieve complete remission after treatment with all-trans retinoic acid (RA). Nevertheless, despite an initial good response, most patients that rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7c0d7cbad227f4589bccde57ae1a97
https://doi.org/10.1182/blood.v83.11.3289.3289
https://doi.org/10.1182/blood.v83.11.3289.3289
Autor:
A. Sakashita, Hideaki Nakajima, M Morikawa, HP Koeffler, Y. Ikeda, Masahiro Kizaki, Ryuji Tanosaki
Publikováno v:
Blood. 82:3592-3599
Retinoic acid modulates proliferation and differentiation of a wide variety of normal and leukemic cells through two distinct families of transcriptional factors: the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). A stereoisomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6403303efa3d4dd3a9df6ddafa5a1b43
https://doi.org/10.1182/blood.v82.12.3592.3592
https://doi.org/10.1182/blood.v82.12.3592.3592
Publikováno v:
Blood. 82:1142-1150
Myeloid cells are a major source of superoxide and other oxygen metabolites. As a protective mechanism, cells express antioxidant enzymes including manganese superoxide dismutase (Mn-SOD), copper-zinc SOD (Cu/Zn-SOD), and glutathione peroxidase (GSX-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af3a101f24a937adc6ca02e89444580
https://doi.org/10.1182/blood.v82.4.1142.bloodjournal8241142
https://doi.org/10.1182/blood.v82.4.1142.bloodjournal8241142
Publikováno v:
Scopus-Elsevier
RNAs for transiently expressed genes such as oncogenes and cytokines, including granulocyte-monocyte colony-stimulating factor (GM-CSF), have a short half-life (T1/2). A cluster of AUUU sequences identified in the 3′ untranslated (UT) region of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f97d8fc5c8cbaa36161a6befcd4c8b
https://doi.org/10.1182/blood.v78.8.2005.2005
https://doi.org/10.1182/blood.v78.8.2005.2005
Publikováno v:
The Journal of endocrinology. 157(2)
By regulating cyclin-cyclin-dependent kinase (CDK) complex activity, individual CDK inhibitors (CDKIs) are potential tumor suppressors. One of the CDKIs, p27/Kip1, binds to a variety of CDK-cyclin complexes. A link between loss of p27/Kip1 function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e278ecc16d30c282942482bb1359c1cf
https://pubmed.ncbi.nlm.nih.gov/9659297
https://pubmed.ncbi.nlm.nih.gov/9659297
Autor:
Hiromichi Matsushita, Y. Ikeda, Akihiro Muto, M Morikawa, HP Koeffler, Masahiro Kizaki, Hironori Ueno, Hideaki Nakajima, M Shimada, Y Yamazoe, Nobuyuki Takayama
Publikováno v:
Europe PubMed Central
Retinoic acid (RA) regulates the differentiation and proliferation of a wide variety of different cell types and all-trans RA induces complete remission in a high proportion of patients with acute promyelocytic leukemia (APL). However, clinical resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5646a0aca10e56b36483107455527fe4
https://pubmed.ncbi.nlm.nih.gov/8555497
https://pubmed.ncbi.nlm.nih.gov/8555497