Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hozaifa Metwally"'
Publikováno v:
Cells, Vol 13, Iss 18, p 1531 (2024)
Threonine phosphorylation promotes inflammatory functions of STAT1 while restricting its interferon (IFN) signaling in innate immune responses. However, it remains unclear whether the restriction of STAT1-mediated IFN signaling conferred by threonine
Externí odkaz:
https://doaj.org/article/ca28f734b74e4924bc87e5d566212c96
Autor:
Shigeru Hashimoto, Tadamitsu Kishimoto, Shimon Sakaguchi, Toshihide Yamashita, Hisataka Sabe, Shinya Tanaka, Yuzo Kodama, Hozaifa Metwally, Yoshihiro Nishikawa, Hirokazu Sugino, Haruka Handa, Takahide Itokazu, Atsushi Sasaki, Takeshi Hirata, Daisuke Okuzaki, Ari Hashimoto, James B. Wing, Murat Tekguc, Gyanu Parajuli
The acquisition of mesenchymal traits leads to immune evasion in various cancers, but the underlying molecular mechanisms remain unclear. In this study, we found that the expression levels of AT-rich interaction domain-containing protein 5a (Arid5a),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264995c8d123984ac13677361b526d2a
https://doi.org/10.1158/2326-6066.c.6550728
https://doi.org/10.1158/2326-6066.c.6550728
Autor:
Shigeru Hashimoto, Tadamitsu Kishimoto, Shimon Sakaguchi, Toshihide Yamashita, Hisataka Sabe, Shinya Tanaka, Yuzo Kodama, Hozaifa Metwally, Yoshihiro Nishikawa, Hirokazu Sugino, Haruka Handa, Takahide Itokazu, Atsushi Sasaki, Takeshi Hirata, Daisuke Okuzaki, Ari Hashimoto, James B. Wing, Murat Tekguc, Gyanu Parajuli
Supplementary Figures 1-8 and Tables 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e1ec7a9dae1a74c3ab8316f1648a9c
https://doi.org/10.1158/2326-6066.22544694
https://doi.org/10.1158/2326-6066.22544694
Autor:
Hozaifa Metwally, Atsushi Sasaki, Shigeru Hashimoto, Yuzo Kodama, Tadamitsu Kishimoto, Ari Hashimoto, Hisataka Sabe, Daisuke Okuzaki, Takahide Itokazu, Murat Tekguc, Hirokazu Sugino, Yoshihiro Nishikawa, Shimon Sakaguchi, James B. Wing, Takeshi Hirata, Haruka Handa, Toshihide Yamashita, Gyanu Parajuli, Shinya Tanaka
Publikováno v:
Cancer Immunology Research. 9:862-876
The acquisition of mesenchymal traits leads to immune evasion in various cancers, but the underlying molecular mechanisms remain unclear. In this study, we found that the expression levels of AT-rich interaction domain-containing protein 5a (Arid5a),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c9816befa709bd0d8c994217287887
https://doi.org/10.1158/2326-6066.cir-21-0014
https://doi.org/10.1158/2326-6066.cir-21-0014
Autor:
Yohannes Gemechu, Hozaifa Metwally, Tadamitsu Kishimoto, Mohammad Mahabub-Uz Zaman, Shailendra Kumar Singh, Yasuharu Nagahama, Sujin Kang, Praveen K Dubey, Gyanu Parajuli, Shigeru Hashimoto, Kazuya Masuda, Hanieh Hamza, Kishan Kumar Nyati, Jaya Prakash Chalise
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Obesity is now considered an epidemic problem worldwide. To develop effective interventions against obesity, we need to understand precisely the regulatory mechanism of adipogenesis, a process of forming adipocytes from fibroblast cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a9f9d5a04c633bb70ec2b5d68ceae6
http://europepmc.org/articles/PMC6660722
http://europepmc.org/articles/PMC6660722
Autor:
Yohannes Gemechu, Shailendra Kumar Singh, Tadamitsu Kishimoto, Hozaifa Metwally, Shigeru Hashimoto, Daisuke Okuzaki, Yu-Chen Liu, Sujin Kang, Kishan K. Nyati, Murat Tekguc
Publikováno v:
Cancer letters. 520
Interleukin (IL-6) is a pleotropic cytokine with both tumor-promoting and -inhibitory effects on breast cancer growth. However, the mechanisms governing the outcome of IL-6 on cancer progression remain to be clarified. Our study unraveled a novel lon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b8af7aaaed8064324f3bb261879ef1
https://pubmed.ncbi.nlm.nih.gov/34389433
https://pubmed.ncbi.nlm.nih.gov/34389433
Autor:
Tadamitsu Kishimoto, Hozaifa Metwally
Publikováno v:
Journal of Cellular Immunology. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8aa1e5e2acec910ab8f48250cfd58c6
https://doi.org/10.33696/immunology.2.044
https://doi.org/10.33696/immunology.2.044
Publikováno v:
The Journal of Experimental Medicine
Kishimoto and colleagues present an overview of the complex biology of interleukin-6 family cytokines, focusing on signaling transduction of the receptor molecule. This review discusses the molecular mechanism of IL-6 expression and how this knowledg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83050244be54a34ba708d9c95bf7fd44
https://pubmed.ncbi.nlm.nih.gov/32267936
https://pubmed.ncbi.nlm.nih.gov/32267936
Publikováno v:
Journal of Experimental Medicine. 217
Interleukin-6 (IL-6) has been identified as a 26-kD secreted protein that stimulates B cells to produce antibodies. Later, IL-6 was revealed to have various functions that overlap with other IL-6 family cytokines and use the common IL-6 signal transd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f936b161bfb93fe4e1d3b53a989d7a92
https://doi.org/10.1084/jem.20190347
https://doi.org/10.1084/jem.20190347
Autor:
Shigeru Hashimoto, Toshio Tanaka, Jaya Prakash Chalise, Yohannes Gemechu, Hamza Hanieh, Gyanu Parajuli, Hozaifa Metwally, Songling Li, Tadamitsu Kishimoto, Sujin Kang, Daron M. Standley
Publikováno v:
Science signaling. 13(624)
The lipopolysaccharide (LPS)-induced endocytosis of Toll-like receptor 4 (TLR4) is an essential step in the production of interferon-β (IFN-β), which activates the transcription of antiviral response genes by STAT1 phosphorylated at Tyr701 Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a1b66b4802f612ec445a43a0c0c758
https://pubmed.ncbi.nlm.nih.gov/32209697
https://pubmed.ncbi.nlm.nih.gov/32209697