First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3 , FOXF1 / FOXC2 / FOXL1 , and HNF1B .

Autor: Gehlen J; Institute of Human Genetics, University Hospital of Marburg, Marburg, Germany., Giel AS; Institute of Human Genetics, University Hospital of Marburg, Marburg, Germany., Köllges R; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Haas SL; Department of Upper GI Diseases, Karolinska University Hospital and Unit of Gastroenterology and Rheumatology, Karolinska Institutet, Stockholm, Sweden., Zhang R; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Trcka J; Department of Paediatric Surgery, 2nd Faculty of Medicine Charles University and Motol University Hospital, Prague, Czech Republic., Sungur AÖ; Behavioural Neuroscience, Experimental and Biological Psychology, University of Marburg, Marburg, Germany., Renziehausen F; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Bornholdt D; Institute of Human Genetics, University Hospital of Marburg, Marburg, Germany., Jung D; Institute of Human Genetics, University Hospital of Marburg, Marburg, Germany.; Department of Pediatric Surgery, University Children's Hospital, Marburg, Germany., Hoyer PD; Department of Pediatric Surgery, University Children's Hospital, Marburg, Germany., Nordenskjöld A; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Department of Paediatric Surgery, Karolinska University Hospital, Stockholm, Sweden., Tibboel D; Department of Pediatric Surgery and Intensive Care, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, the Netherlands., Vlot J; Department of Pediatric Surgery and Intensive Care, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, the Netherlands., Spaander MCW; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands., Smigiel R; Department of Pediatrics, Division of Pediatrics and Rare Disorders, Wroclaw Medical University, Wroclaw, Poland., Patkowski D; Department of Pediatric Surgery and Urology, Wroclaw Medical University, Wroclaw, Poland., Roeleveld N; Department for Health Evidence, Radboud Institute for Health Sciences, Radboudumc, Nijmegen, the Netherlands., van Rooij IA; Department for Health Evidence, Radboud Institute for Health Sciences, Radboudumc, Nijmegen, the Netherlands., de Blaauw I; Department of Surgery, Pediatric Surgery, Radboudumc Amalia Children's Hospital, Nijmegen, the Netherlands., Hölscher A; Department of Pediatric Surgery and Urology, University Hospital Cologne, Cologne, Germany., Pauly M; Department of Pediatric Surgery, Asklepios Children's Hospital St. Augustin, St. Augustin, Germany., Leutner A; Department of Pediatric Surgery, Medical Center Dortmund, Dortmund, Germany., Fuchs J; Department of Pediatric Surgery Children's Hospital, University of Tübingen, Tübingen, Germany., Niethammer J; Department of Pediatric Surgery Children's Hospital, University of Tübingen, Tübingen, Germany., Melissari MT; Institute of Cardiovascular Regeneration, Center for Molecular Medicine, University of Frankfurt, Frankfurt am Main, Germany., Jenetzky E; School of Medicine, Faculty of Health, University of Witten/Herdecke, Witten, Germany.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Zwink N; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Thiele H; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Hilger AC; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Pediatrics, Children's Hospital, University Hospital Bonn, Bonn, Germany., Hess T; Institute of Human Genetics, University Hospital of Marburg, Marburg, Germany., Trautmann J; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Marks M; Clinic for Neurology, Section Neurobiological Research, RWTH Aachen University Clinic, Aachen, Germany.; Institute for Biology II, Department for Neurobiological Research, RWTH Aachen University, Aachen, Germany., Baumgarten M; Institute of Human Genetics, University Hospital of Marburg, Marburg, Germany., Bläss G; Department of Developmental Genetics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany., Landén M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Fundin B; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Bulik CM; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Pennimpede T; Department of Developmental Genetics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany.; Division of Cancer Biology and Genetics, Queen's University, Kingston, Canada., Ludwig M; Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany., Ludwig KU; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Mangold E; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Moebus S; Institute of Urban Public Health, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Herrmann BG; Department of Developmental Genetics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany., Alsabeah K; Department of Upper GI Diseases, Karolinska University Hospital and Unit of Gastroenterology and Rheumatology, Karolinska Institutet, Stockholm, Sweden., Burgos CM; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Department of Paediatric Surgery, Karolinska University Hospital, Stockholm, Sweden., Lilja HE; Department of Women's and Children's Health, Section of Pediatric Surgery, Uppsala University, Uppsala, Sweden., Azodi S; Perioperative Medicine and Intensive Care, Karolinska University, Stockholm, Sweden., Stenström P; Department of Pediatric Surgery, Skåne University Hospital, Lund, Sweden., Arnbjörnsson E; Department of Pediatric Surgery, Skåne University Hospital, Lund, Sweden., Frybova B; Department of Paediatric Surgery, 2nd Faculty of Medicine Charles University and Motol University Hospital, Prague, Czech Republic., Lebensztejn DM; Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Bialystok, Poland., Debek W; Department of Pediatric Surgery and Urology, Medical University of Bialystok, Poland., Kolodziejczyk E; Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland., Kozera K; Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland., Kierkus J; Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland., Kaliciński P; Gastroenterology, Allergology and Pediatric Department, Polish-Mother's Memorial Hospital. Research Institute, Lodz, Poland., Stefanowicz M; Gastroenterology, Allergology and Pediatric Department, Polish-Mother's Memorial Hospital. Research Institute, Lodz, Poland., Socha-Banasiak A; Gastroenterology, Allergology and Pediatric Department, Polish-Mother's Memorial Hospital. Research Institute, Lodz, Poland., Kolejwa M; Gastroenterology, Allergology and Pediatric Department, Polish-Mother's Memorial Hospital. Research Institute, Lodz, Poland., Piaseczna-Piotrowska A; Department of Pediatric Surgery, Urology and Transplantology, The Children's Memorial Health Institute, Warsaw, Poland., Czkwianianc E; Gastroenterology, Allergology and Pediatric Department, Polish-Mother's Memorial Hospital. Research Institute, Lodz, Poland., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Grote P; Institute of Cardiovascular Regeneration, Center for Molecular Medicine, University of Frankfurt, Frankfurt am Main, Germany., Rygl M; Department of Paediatric Surgery, 2nd Faculty of Medicine Charles University and Motol University Hospital, Prague, Czech Republic., Reinshagen K; Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Spychalski N; Department of Pediatric Surgery and Urology, Cnopf'sche Kinderklinik, Nürnberg, Germany., Ludwikowski B; Department of Pediatric Surgery and Pediatric Urology, Medical Center for Children and Adolescents 8AUF DER BULT, Hannover, Germany., Hubertus J; Department of Pediatric Surgery, Marien Hospital Witten, Ruhr-University Bochum, Germany., Heydweiller A; Department of Pediatric Surgery, University Hospital Bonn, Bonn, Germany., Ure B; Center of Pediatric Surgery Hannover, Hannover Medical School, Hannover, Germany., Muensterer OJ; Department of Pediatric Surgery, University Medicine Mainz, Mainz, Germany.; Department of Pediatric Surgery, Dr. von Haunersches Kinderspital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany., Aubert O; Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany., Gosemann JH; Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany., Lacher M; Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany., Degenhardt P; Department of Pediatric Surgery, Ernst von Bergmann Hospital, Potsdam, Germany., Boemers TM; Department of Pediatric Surgery and Urology, University Hospital Cologne, Cologne, Germany., Mokrowiecka A; Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland., Małecka-Panas E; Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland., Wöhr M; Behavioural Neuroscience, Experimental and Biological Psychology, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior, Philipps-University Marburg, Marburg, Germany.; Faculty of Psychology and Educational Sciences, Research Unit Brain and Cognition, Laboratory of Biological Psychology, Social and Affective Neuroscience Research Group, Leuven, Belgium.; KU Leuven, Leuven Brain Institute, Leuven, Belgium., Knapp M; Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, Germany., Seitz G; Department of Pediatric Surgery, University Children's Hospital, Marburg, Germany., de Klein A; Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, the Netherlands., Oracz G; Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland., Brosens E; Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, the Netherlands., Reutter H; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, University Hospital, Erlangen, Germany., Schumacher J; Institute of Human Genetics, University Hospital of Marburg, Marburg, Germany.; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.

Publikováno v: HGG advances [HGG Adv] 2022 Jan 25; Vol. 3 (2), pp. 100093. Date of Electronic Publication: 2022 Jan 25 (Print Publication: 2022).