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Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans .

Autor: Rivera A; Department of Pharmacology and Cancer Biology, Duke University Medical Center , Durham, North Carolina, USA., Young Lim W; Department of Chemistry, Duke University , Durham, North Carolina, USA., Park E; Department of Integrative Immunobiology, Duke University Medical Center , Durham, North Carolina, USA., Dome PA; Department of Chemistry, Duke University , Durham, North Carolina, USA., Hoy MJ; Department of Molecular Genetics and Microbiology, Duke University Medical Center , Durham, North Carolina, USA., Spasojevic I; Department of Medicine, Duke University Medical Center , Durham, North Carolina, USA., Sun S; Department of Molecular Genetics and Microbiology, Duke University Medical Center , Durham, North Carolina, USA., Averette AF; Department of Molecular Genetics and Microbiology, Duke University Medical Center , Durham, North Carolina, USA., Pina-Oviedo S; Department of Pathology, Duke University Medical Center , Durham, North Carolina, USA., Juvvadi PR; Department of Pediatrics, University of Arkansas for Medical Sciences , Little Rock, Arkansas, USA., Steinbach WJ; Department of Pediatrics, University of Arkansas for Medical Sciences , Little Rock, Arkansas, USA., Ciofani M; Department of Integrative Immunobiology, Duke University Medical Center , Durham, North Carolina, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical Center , Durham, North Carolina, USA., Hong J; Department of Pharmacology and Cancer Biology, Duke University Medical Center , Durham, North Carolina, USA.; Department of Chemistry, Duke University , Durham, North Carolina, USA., Heitman J; Department of Pharmacology and Cancer Biology, Duke University Medical Center , Durham, North Carolina, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical Center , Durham, North Carolina, USA.

Publikováno v: MBio [mBio] 2023 Oct 31; Vol. 14 (5), pp. e0181023. Date of Electronic Publication: 2023 Sep 22.

Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.

Autor: Hoy MJ; Department of Molecular Genetics and Microbiology, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA., Park E; Department of Immunology, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA., Lee H; Department of Chemistry, Duke Universitygrid.26009.3d, Durham, North Carolina, USA., Lim WY; Department of Chemistry, Duke Universitygrid.26009.3d, Durham, North Carolina, USA., Cole DC; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA., DeBouver ND; UCB Biosciences, Bainbridge Island, Washington, USA.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA., Bobay BG; Duke Universitygrid.26009.3d NMR Center, Durham, North Carolina, USA., Pierce PG; UCB Biosciences, Bainbridge Island, Washington, USA.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA., Fox D 3rd; UCB Biosciences, Bainbridge Island, Washington, USA.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA., Ciofani M; Department of Immunology, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA., Juvvadi PR; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA., Steinbach W; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA., Hong J; Department of Chemistry, Duke Universitygrid.26009.3d, Durham, North Carolina, USA., Heitman J; Department of Molecular Genetics and Microbiology, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA.

Publikováno v: MBio [mBio] 2022 Jun 28; Vol. 13 (3), pp. e0104922. Date of Electronic Publication: 2022 May 23.

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.

Autor: Juvvadi PR; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA. praveen.juvvadi@duke.edu., Fox D 3rd; Beryllium Discovery Corp., 7869 NE Day Road West, Bainbridge Island, WA, 98110, USA.; UCB Pharma., 7869 NE Day Road West, Bainbridge Island, WA, 98110, USA.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, USA., Bobay BG; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA.; Department of Biochemistry, Duke University, Durham, NC, 27710, USA.; Department of Radiology, Duke University, Durham, NC, 27710, USA., Hoy MJ; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA., Gobeil SMC; Department of Biochemistry, Duke University, Durham, NC, 27710, USA.; Department of Radiology, Duke University, Durham, NC, 27710, USA., Venters RA; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA.; Department of Biochemistry, Duke University, Durham, NC, 27710, USA.; Department of Radiology, Duke University, Durham, NC, 27710, USA., Chang Z; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA., Lin JJ; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA., Averette AF; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA., Cole DC; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA., Barrington BC; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA., Wheaton JD; Department of Immunology, Duke University Medical Center, Durham, NC, 27710, USA., Ciofani M; Department of Immunology, Duke University Medical Center, Durham, NC, 27710, USA., Trzoss M; Amplyx Pharmaceuticals, 3210 Merryfield Row, San Diego, CA, 92121, USA., Li X; Amplyx Pharmaceuticals, 3210 Merryfield Row, San Diego, CA, 92121, USA.; Forge Therapeutics, Inc., 10578 Science Center Drive, San Diego, CA, 92121, USA., Lee SC; South Texas Center for Emerging Infectious Diseases, Department of Biology, The University of Texas at San Antonio, San Antonio, TX, 78249, USA., Chen YL; Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, 10617, Taiwan., Mutz M; Amplyx Pharmaceuticals, 3210 Merryfield Row, San Diego, CA, 92121, USA.; Genentech Inc., 1 DNA Way, San Francisco, CA, 94080, USA., Spicer LD; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA.; Department of Biochemistry, Duke University, Durham, NC, 27710, USA.; Department of Radiology, Duke University, Durham, NC, 27710, USA., Schumacher MA; Department of Biochemistry, Duke University, Durham, NC, 27710, USA., Heitman J; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA., Steinbach WJ; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA. bill.steinbach@duke.edu.; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA. bill.steinbach@duke.edu.

Publikováno v: Nature communications [Nat Commun] 2019 Sep 19; Vol. 10 (1), pp. 4275. Date of Electronic Publication: 2019 Sep 19.