Comparing Long-Term Prognosis in Chronic Critically Ill Patients: A Case Series Study of Medical versus Surgical Sepsis.

Autor: Mancini B; Penn State College of Medicine, 500 University Dr., Hershey, PA 17033, USA., Liu J; Department of Anesthesiology, Critical Care & Pain Management, Hospital for Special Surgery, New York, NY 10021, USA.; Department of Anesthesiology, Weill Cornell Medical College, New York, NY 10021, USA., Samuelsen A; Department of Anesthesiology and Perioperative Medicine, Division of Critical Care Medicine, Penn State Hershey Medical Center, 500 University Dr., Hershey, PA 17033, USA., Howrylak JA; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Penn State Hershey Medical Center, 500 University Dr., Hershey, PA 17033, USA., Schultz L; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Penn State Hershey Medical Center, 500 University Dr., Hershey, PA 17033, USA., Bonavia AS; Department of Anesthesiology and Perioperative Medicine, Division of Critical Care Medicine, Penn State Hershey Medical Center, 500 University Dr., Hershey, PA 17033, USA.

Publikováno v: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2023 Sep 07; Vol. 59 (9). Date of Electronic Publication: 2023 Sep 07.

Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation.

Autor: Englert JA; Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State Wexner Medical Center, 201 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH, 43210, USA. joshua.englert@osumc.edu., Cho MH; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA., Lamb AE; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA., Shumyatcher M; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, 402 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104, USA., Barragan-Bradford D; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA., Basil MC; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA., Higuera A; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA., Isabelle C; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA., Vera MP; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA., Dieffenbach PB; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA., Fredenburgh LE; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA., Kang JB; Departments of Medicine and Genetics, Stanford University, CCSR1155b, 269 Campus Drive, Palo Alto, CA, 93405, USA., Bhatt AS; Departments of Medicine and Genetics, Stanford University, CCSR1155b, 269 Campus Drive, Palo Alto, CA, 93405, USA., Antin JH; Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA., Ho VT; Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA., Soiffer RJ; Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA., Howrylak JA; Division of Pulmonary and Critical Care Medicine, Penn State Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA., Himes BE; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, 402 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104, USA., Baron RM; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Publikováno v: Respiratory research [Respir Res] 2019 Jan 21; Vol. 20 (1), pp. 15. Date of Electronic Publication: 2019 Jan 21.

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.

Autor: Sweeney TE; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA.; Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA., Azad TD; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA.; Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA., Donato M; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA.; Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA., Haynes WA; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA.; Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA., Perumal TM; Sage Bionetworks, Seattle, WA., Henao R; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC.; Department of Electrical and Computer Engineering, Duke University, Durham, NC., Bermejo-Martin JF; Bio Sepsis, Hospital Clínico Universitario de Valladolid/IECSCYL, Valladolid, Spain., Almansa R; Bio Sepsis, Hospital Clínico Universitario de Valladolid/IECSCYL, Valladolid, Spain., Tamayo E; Bio Sepsis, Hospital Clínico Universitario de Valladolid/IECSCYL, Valladolid, Spain., Howrylak JA; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA., Choi A; Department of Medicine, Cornell Medical Center, New York, NY., Parnell GP; Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Sydney, NSW, Australia., Tang B, Nichols M; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC., Woods CW; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC.; Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC.; Durham Veteran's Affairs Health Care System, Durham, NC., Ginsburg GS; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC., Kingsmore SF; Rady Children's Institute for Genomic Medicine, San Diego, CA., Omberg L; Sage Bionetworks, Seattle, WA., Mangravite LM; Sage Bionetworks, Seattle, WA., Wong HR; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Research Foundation, Cincinnati, OH.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH., Tsalik EL; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC.; Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC.; Durham Veteran's Affairs Health Care System, Durham, NC., Langley RJ; Department of Pharmacology, University of South Alabama, Mobile, AL., Khatri P; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA.; Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA.

Publikováno v: Critical care medicine [Crit Care Med] 2018 Jun; Vol. 46 (6), pp. 915-925.

A community approach to mortality prediction in sepsis via gene expression analysis.

Autor: Sweeney TE; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Inflammatix Inc., Burlingame, CA, 94010, USA., Perumal TM; Sage Bionetworks, Seattle, WA, 98109, USA., Henao R; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC, 27708, USA.; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA., Nichols M; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC, 27708, USA., Howrylak JA; Division of Pulmonary and Critical Care Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA, 17033, USA., Choi AM; Department of Medicine, Cornell Medical Center, New York, NY, 10065, USA., Bermejo-Martin JF; Hospital Clínico Universitario de Valladolid/IECSCYL, Valladolid, 47005, Spain., Almansa R; Hospital Clínico Universitario de Valladolid/IECSCYL, Valladolid, 47005, Spain., Tamayo E; Hospital Clínico Universitario de Valladolid/IECSCYL, Valladolid, 47005, Spain., Davenport EE; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Partners Center for Personalized Genetic Medicine, Boston, MA, 02115, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Burnham KL; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Hinds CJ; William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University, London, EC1M 6BQ, UK., Knight JC; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Woods CW; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC, 27708, USA.; Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC, 27710, USA.; Durham Veteran's Affairs Health Care System, Durham, NC, 27705, USA., Kingsmore SF; Rady Children's Institute for Genomic Medicine, San Diego, CA, 92123, USA., Ginsburg GS; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC, 27708, USA., Wong HR; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Research Foundation, Cincinnati, OH, 45223, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA., Parnell GP; Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Westmead, NSW, 2145, Australia., Tang B; Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, Westmead, NSW, 2145, Australia.; Department of Intensive Care Medicine, Nepean Hospital, Sydney, Australia, Penrith, NSW, 2751, Australia.; Nepean Genomic Research Group, Nepean Clinical School, University of Sydney, Penrith, NSW, 2751, Australia.; Marie Bashir Institute for Infectious Diseases and Biosecurity, Westmead, NSW, 2145, Australia., Moldawer LL; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, 32610, USA., Moore FE; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, 32610, USA., Omberg L; Sage Bionetworks, Seattle, WA, 98109, USA., Khatri P; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Tsalik EL; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC, 27708, USA.; Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC, 27710, USA.; Durham Veteran's Affairs Health Care System, Durham, NC, 27705, USA., Mangravite LM; Sage Bionetworks, Seattle, WA, 98109, USA., Langley RJ; Department of Pharmacology, University of South Alabama, Mobile, AL, 36688, USA. rlangley@southalabama.edu.

Publikováno v: Nature communications [Nat Commun] 2018 Feb 15; Vol. 9 (1), pp. 694. Date of Electronic Publication: 2018 Feb 15.

NLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B 4 Synthesis.

Autor: Lee S; 1 Division of Pulmonary and Critical Care Medicine and.; 2 Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Nakahira K; 1 Division of Pulmonary and Critical Care Medicine and.; 3 Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York., Dalli J; 4 Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Harvard Institutes of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Siempos II; 1 Division of Pulmonary and Critical Care Medicine and.; 3 Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York.; 5 First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, University of Athens Medical School, Athens, Greece., Norris PC; 4 Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Harvard Institutes of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Colas RA; 4 Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Harvard Institutes of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Moon JS; 1 Division of Pulmonary and Critical Care Medicine and.; 3 Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York., Shinohara M; 4 Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Harvard Institutes of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Hisata S; 1 Division of Pulmonary and Critical Care Medicine and.; 3 Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York., Howrylak JA; 6 Division of Pulmonary and Critical Care Medicine, Penn State College of Medicine, Hershey, Pennsylvania; and., Suh GY; 2 Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Ryter SW; 1 Division of Pulmonary and Critical Care Medicine and.; 3 Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York., Serhan CN; 4 Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Harvard Institutes of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Choi AMK; 1 Division of Pulmonary and Critical Care Medicine and.; 3 Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, New York.; 7 New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2017 Sep 15; Vol. 196 (6), pp. 713-726.