Predicting treatment-resistance from first-episode psychosis using routinely collected clinical information: development and external validation study

Autor: Osimo, E, Perry, BI, Mallikarjun, P, Pritchard, M, Lewis, J, Katunda, A, Murray, GK, Perez, J, Jones, PB, Cardinal, RN, Howes, OD, Upthegrove, R, Khandaker, GM

Around a quarter of people who experience a first episode of psychosis (FEP) will develop treatment-resistant schizophrenia (TRS), but there are currently no established clinically useful methods to predict this from baseline. We aimed to explore the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::9585bd8e28cc70e5808d6d9b79fe8b5e
http://hdl.handle.net/10044/1/100290

Antipsychotic treatment resistance in first-episode psychosis:prevalence, subtypes and predictors

Autor: Demjaha, A, Lappin, JM, Stahl, D, Patel, MX, MacCabe, JH, Howes, OD, Heslin, M, Reininghaus, Ulrich, Donoghue, K, Lomas, B, Charalambides, M, Onyejiaka, A, Fearon, P, Jones, P, Doody, G, Morgan, C, Dazzan, P, Murray, RM

Publikováno v: Demjaha, A, Lappin, J M, Stahl, D, Patel, M X, MacCabe, J H, Howes, O D, Heslin, M, Reininghaus, U A, Donoghue, K, Lomas, B, Charalambides, M, Onyejiaka, A, Fearon, P, Jones, P, Doody, G, Morgan, C, Dazzan, P & Murray, R M 2017, ' Antipsychotic treatment resistance in first-episode psychosis : prevalence, subtypes and predictors ', Psychological Medicine, vol. 47, no. 11, pp. 1981-1989 . https://doi.org/10.1017/S0033291717000435

BACKGROUND: We examined longitudinally the course and predictors of treatment resistance in a large cohort of first-episode psychosis (FEP) patients from initiation of antipsychotic treatment. We hypothesized that antipsychotic treatment resistance i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7bfeb236b1d18043013ba518c02b951e
https://kclpure.kcl.ac.uk/ws/files/67495602/Antipsychotic_treatment_resistance_in_DEMJAHA_FirstonlineApril112017_GOLD_VoR_CC_BY_.pdf

A test of the transdiagnostic dopamine hypothesis of psychosis using positron emission tomographic imaging in bipolar affective disorder and schizophrenia

Autor: Jauhar, S, Nour, MM, Veronese, M, Rogdaki, M, Bonoldi, I, Azis, M, Turkheimer, F, McGuire, P, Young, AH, Howes, OD

Publikováno v: Jauhar, S, Nour, M M, Veronese, M, Rogdaki, M, Bonoldi, I, Azis, M, Turkheimer, F, McGuire, P, Young, A H & Howes, O D 2017, ' A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia ', JAMA Psychiatry, vol. 74, no. 12, pp. 1206-1213 . https://doi.org/10.1001/jamapsychiatry.2017.2943

Importance: The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar affective disorder and schizophrenia, in line with the research domain criteria appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::47da7c231cbbc78213b1de8fdc53a043
https://hdl.handle.net/11577/3461355

Brain microglia in psychiatric disorders

Autor: Mondelli, Valeria, Vernon, Anthony C, Turkheimer, Federico, Dazzan, Paola, Pariante, Carmine M, Frost, JL, Schafer, DP, Banati, RB, Newcombe, J, Gunn, RN, al., et, Tang, Y, Le, W, Estes, ML, McAllister, AK, Ransohoff, RM, Davalos, D, Grutzendler, J, Yang, G, Peferoen, LA, Vogel, DY, Ummenthum, K, Norden, DM, Trojanowski, PJ, Villanueva, E, Navarro, E, Godbout, JP, Kreisel, T, Frank, MG, Licht, T, Wachholz, S, Eßlinger, M, Plümper, J, Manitz, MP, Juckel, G, Friebe, A, Trépanier, MO, Hopperton, KE, Mizrahi, R, Mechawar, N, Bazinet, RP, Torres-Platas, SG, Cruceanu, C, Chen, GG, Turecki, G, Steiner, J, Bielau, H, Brisch, R, Schnieder, TP, Trencevska, I, Rosoklija, G, Fillman, SG, Cloonan, N, Catts, VS, Rupprecht, R, Papadopoulos, V, Rammes, G, Qiu, ZK, Li, MS, He, JL, Hannestad, J, Gallezot, JD, Schafbauer, T, Israel, I, Ohsiek, A, Al-Momani, E, Mirzaei, N, Tang, SP, Ashworth, S, Gulyás, B, Makkai, B, Kása, P, Turkheimer, FE, Rizzo, G, Bloomfield, PS, Owen, DR, Yeo, AJ, DellaGioia, N, Setiawan, E, Wilson, AA, Su, L, Faluyi, YO, Hong, YT, Haarman, BC, Lek, RF Riemersma-Van der, Groot, JC de, Berckel, BN van, Bossong, MG, Boellaard, R, Doorduin, J, Vries, EF de, Willemsen, AT, Dierckx, RA, Klein, HC, Takano, A, Arakawa, R, Ito, H, Kenk, M, Selvanathan, T, Rao, N, Selvaraj, S, Veronese, M, Coughlin, JM, Wang, Y, Ambinder, EB, Doef, TF van der, Witte, LD de, Sutterland, AL, Hafizi, S, Tseng, HH, Holmes, SE, Hinz, R, Drake, RJ, Yaqub, M, Schuitemaker, A, Edison, P, Pavese, N, Lockhart, A, Davis, B, Matthews, JC, Quarantelli, M, Laule, C, Vavasour, IM, Kolind, SH, Pasternak, O, Sochen, N, Gur, Y, Intrator, N, Assaf, Y, Andreasen, NC, Ehrhardt, JC, Swayze, VW, Supprian, T, Hofmann, E, Warmuth-Metz, M, Franzek, E, Becker, T, Pfefferbaum, A, Sullivan, EV, Hedehus, M, Moseley, M, Lim, KO, Mandl, RC, Schnack, HG, Luigjes, J, Cahn, W, Bagary, MS, Symms, MR, Barker, GJ, Mutsatsa, SH, Joyce, EM, Ron, MA, Foong, J, Maier, M, Brocklehurst, S, Miller, DH, Kubicki, M, Park, H, Westin, CF, Bouix, S, Dahlben, B, Oestreich, LK, Shenton, ME, Amato, D, Beasley, CL, Hahn, MK, Vernon, AC, Natesan, S, Modo, M, Kapur, S, Mondelli, V, Reininghaus, U, Kempton, MJ, Valmaggia, L, Baumeister, D, Lightman, SL, Pariante, CM, Danese, A, Moffitt, TE, Ambler, A, Poulton, R, Caspi, A, Akhtar, R, Ciufolini, S, Meyer, U, So, PW, Lythgoe, DJ, Cotel, MC, Lenartowicz, EM, Anacker, C, Calcia, MA, Bonsall, DR, Barichello, T, Howes, OD, Burke, NN, Fan, CY, Trang, T, McMahon, SB, Russa, F La, Bennett, DL, Püntener, U, Booth, SG, Perry, VH, Teeling, JL, Hahn, YK, Podhaizer, EM, Farris, SP, Miles, MF, Hauser, KF, Knapp, PE, Notter, T, Gschwind, T, Varga, B, Markó, K, Hádinger, N, Cattaneo, A, Ferrari, C, Uher, R, Belvederi, Murri M, Sandiego, CM, Pittman, B, Weber, MD, Sheridan, JF, Raison, CL, Rutherford, RE, Woolwine, BJ, Möller, T, Boddeke, HW, O'Connor, JC, Lawson, MA, André, C, Hinwood, M, Morandini, J, Day, TA, Walker, FR, Bard, F, Bhattacharya, A, Pae, CU, Marks, DM, Han, C, Patkar, AA, Oya, K, Kishi, T, Iwata, N

Publikováno v: Lancet psychiatry, 0(0), 587-597. Elsevier Limited
Mondelli, V, Vernon, A C, Turkheimer, F E, Dazzan, P & Pariante, C M 2017, ' Brain microglia in psychiatric disorders ', The Lancet Psychiatry, vol. 4, no. 7, pp. 563-572 . https://doi.org/10.1016/S2215-0366(17)30101-3
Mondelli, V, Vernon, A C, Turkheimer, F, Dazzan, P, Pariante, C M, Frost, JL, Schafer, DP, Banati, RB, Newcombe, J, Gunn, RN, al., E, Tang, Y, Le, W, Estes, ML, McAllister, AK, Ransohoff, RM, Davalos, D, Grutzendler, J, Yang, G, al., E, Peferoen, LA, Vogel, DY, Ummenthum, K, al., E, Norden, DM, Trojanowski, PJ, Villanueva, E, Navarro, E, Godbout, JP, Kreisel, T, Frank, MG, Licht, T, al., E, Wachholz, S, Eßlinger, M, Plümper, J, Manitz, MP, Juckel, G, Friebe, A, Trépanier, MO, Hopperton, KE, Mizrahi, R, Mechawar, N, Bazinet, RP, Torres-Platas, SG, Cruceanu, C, Chen, GG, Turecki, G, Mechawar, N, Steiner, J, Bielau, H, Brisch, R, al., E, Schnieder, TP, Trencevska, I, Rosoklija, G, al., E, Fillman, SG, Cloonan, N, Catts, VS, al., E, Rupprecht, R, Papadopoulos, V, Rammes, G, al., E, Qiu, ZK, Li, MS, He, JL, al., E, Hannestad, J, Gallezot, JD, Schafbauer, T, al., E, Israel, I, Ohsiek, A, Al-Momani, E, al., E, Mirzaei, N, Tang, SP, Ashworth, S, al., E, Gulyás, B, Makkai, B, Kása, P, al., E, Turkheimer, FE, Rizzo, G, Bloomfield, PS, al., E, Owen, DR, Yeo, AJ, Gunn, RN, al., E, Hannestad, J, DellaGioia, N, Gallezot, JD, al., E, Setiawan, E, Wilson, AA, Mizrahi, R, al., E, Su, L, Faluyi, YO, Hong, YT, al., E, Haarman, BC, Lek, RF R-V D, Groot, JC D, al., E, Berckel, BN V, Bossong, MG, Boellaard, R, al., E, Doorduin, J, Vries, EF D, Willemsen, AT, Groot, JC D, Dierckx, RA, Klein, HC, Takano, A, Arakawa, R, Ito, H, al., E, Kenk, M, Selvanathan, T, Rao, N, al., E, Bloomfield, PS, Selvaraj, S, Veronese, M, al., E, Coughlin, JM, Wang, Y, Ambinder, EB, al., E, Doef, TF V D, Witte, LD D, Sutterland, AL, al., E, Hafizi, S, Tseng, HH, Rao, N, al., E, Holmes, SE, Hinz, R, Drake, RJ, al., E, Yaqub, M, Berckel, BN V, Schuitemaker, A, al., E, Turkheimer, FE, Edison, P, Pavese, N, al., E, Lockhart, A, Davis, B, Matthews, JC, al., E, Quarantelli, M, Laule, C, Vavasour, IM, Kolind, SH, al., E, Pasternak, O, Sochen, N, Gur, Y, Intrator, N, Assaf, Y, Andreasen, NC, Ehrhardt, JC, Swayze, VW, al., E, Supprian, T, Hofmann, E, Warmuth-Metz, M, Franzek, E, Becker, T, Pfefferbaum, A, Sullivan, EV, Hedehus, M, Moseley, M, Lim, KO, Mandl, RC, Schnack, HG, Luigjes, J, al., E, Mandl, RC, Pasternak, O, Cahn, W, al., E, Bagary, MS, Symms, MR, Barker, GJ, Mutsatsa, SH, Joyce, EM, Ron, MA, Foong, J, Maier, M, Barker, GJ, Brocklehurst, S, Miller, DH, Ron, MA, Foong, J, Symms, MR, Barker, GJ, al., E, Kubicki, M, Park, H, Westin, CF, al., E, Bagary, MS, Foong, J, Maier, M, al., E, Pasternak, O, Westin, CF, Bouix, S, Pasternak, O, Westin, CF, Dahlben, B, Bouix, S, Kubicki, M, Oestreich, LK, Pasternak, O, Shenton, ME, al., E, Amato, D, Beasley, CL, Hahn, MK, Vernon, AC, Vernon, AC, Natesan, S, Modo, M, Kapur, S, Mondelli, V, Reininghaus, U, Kempton, MJ, Valmaggia, L, al., E, Baumeister, D, Lightman, SL, Pariante, CM, Danese, A, Moffitt, TE, Pariante, CM, Ambler, A, Poulton, R, Caspi, A, Baumeister, D, Akhtar, R, Ciufolini, S, Pariante, CM, Mondelli, V, Meyer, U, Vernon, AC, So, PW, Lythgoe, DJ, al., E, Cotel, MC, Lenartowicz, EM, Natesan, S, al., E, Mondelli, V, Anacker, C, Vernon, AC, al., E, Calcia, MA, Bonsall, DR, Bloomfield, PS, Selvaraj, S, Barichello, T, Howes, OD, Burke, NN, Fan, CY, Trang, T, McMahon, SB, Russa, F L, Bennett, DL, Püntener, U, Booth, SG, Perry, VH, Teeling, JL, Hahn, YK, Podhaizer, EM, Farris, SP, Miles, MF, Hauser, KF, Knapp, PE, Notter, T, Coughlin, JM, Gschwind, T, al., E, Varga, B, Markó, K, Hádinger, N, al., E, Cattaneo, A, Ferrari, C, Uher, R, al., E, Mondelli, V, Ciufolini, S, Belvederi, M M, al., E, Sandiego, CM, Gallezot, JD, Pittman, B, al., E, Weber, MD, Godbout, JP, Sheridan, JF, Raison, CL, Rutherford, RE, Woolwine, BJ, al., E, Möller, T, Boddeke, HW, O'Connor, JC, Lawson, MA, André, C, al., E, Hinwood, M, Morandini, J, Day, TA, Walker, FR, Möller, T, Bard, F, Bhattacharya, A, al., E, Pae, CU, Marks, DM, Han, C, Patkar, AA, Oya, K, Kishi, T, Iwata, N, Baumeister, D, Ciufolini, S & Mondelli, V 2016, ' Brain microglia in psychiatric disorders ', Lancet psychiatry, vol. 0, no. 0, pp. 587-597 . https://doi.org/10.1016/S2215-0366(17)30101-3

SummaryThe role of immune activation in psychiatric disorders has attracted considerable attention over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the macrophages of the brain, are progressively becoming th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1698f7e9b3eca5ef43eb16cacb00b091
https://research.vumc.nl/en/publications/07f168d1-2b4d-4483-b9b1-1659ff4e83f8

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