Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Howe, SJ"'
Autor:
Vink, CA, Counsell, JR, Perocheau, DP, Karda, R, Buckley, SMK, Brugman, MH, Galla, M, Schambach, A, McKay, Tristan, Waddington, SN, Howe, SJ
Lentiviral vector genomic RNA requires sequences that partially overlap wild-type HIV-1 gag and env genes for packaging into vector particles. These HIV-1 packaging sequences constitute 19.6% of the wild-type HIV-1 genome and contain functional cis e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______128::e9592e0127cf5919d8f3600395b67355
https://e-space.mmu.ac.uk/618767/
https://e-space.mmu.ac.uk/618767/
Autor:
Munye, MM, Shoemark, A, Hirst, RA, Delhove, JM, Sharp, TV, McKay, TR, O'Callaghan, C, Baines, DL, Howe, SJ, Hart, SL
Air-liquid interface (ALI) culture of primary airway epithelial cells enables mucociliary differentiation providing an in vitro model of the human airway but their proliferative potential is limited. To extend proliferation, these cells were previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7f9570a3e6124aa2a9aa124fff2971f1
Akademický článek
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Publikováno v:
Neuropharmacology. 21:555-562
The relationship between the plasma concentration of valproic acid (VPA) and anticonvulsant or neurotoxic effects was studied in the rat. Anticonvulsant activity was assessed against; (1) maximal seizures induced either by electroshock or by intraven
Akademický článek
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Autor:
A MacNeil, Ulrich Abel, Daniela Cesana, Christof von Kalle, Cynthia C. Bartholomae, Adrian J. Thrasher, Jens Uwe Appelt, Hanno Glimm, Eugenio Montini, Bernhard Korn, Anna Paruzynski, Luigi Naldini, Rafael J. Yáñez-Muñoz, Anne Arens, Steven J. Howe, Kamaljit S. Balaggan, Manfred Schmidt, Robin R. Ali
Publikováno v:
Molecular Therapy; Vol 19
Lentiviral vectors with self-inactivating (SIN) long terminal repeats (LTRs) are promising for safe and sustained transgene expression in dividing as well as quiescent cells. As genome organization and transcription substantially differs between acti
Autor:
Adrian J. Thrasher, Fulvio Mavilio, Anna Paruzynski, Steven J. Howe, Claudia Cattoglio, Manuel Grez, Hanno Glimm, Dieter Hoelzer, H. Bobby Gaspar, Gerard Wagemaker, Manfred Schmidt, Annette Deichmann, Ulrich Abel, Richard Gabriel, Alessandro Aiuti, Marina Cavazzana-Calvo, Kerstin Schwarzwaelder, Salima Hacein-Bey-Abina, Monique M A Verstegen, Cynthia C. Bartholomae, Cynthia E. Dunbar, Barbara Cassani, Alain Fischer, Christof von Kalle, Marion Ott, Reinhard Seger, Martijn H. Brugman, Anne Arens, Christopher Baum
Publikováno v:
Molecular Therapy; Vol 19
Molecular Therapy, 19(11), 2031-2039. Cell Press
Molecular Therapy, 19(11), 2031-2039. Cell Press
Vector-associated side effects in clinical gene therapy have provided insights into the molecular mechanisms of hematopoietic regulation in vivo. Surprisingly, many retrovirus insertion sites (RIS) present in engrafted cells have been found to cluste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ee642a7fb49b8ff837ce63aa36e203
https://europepmc.org/articles/PMC3222531/
https://europepmc.org/articles/PMC3222531/
Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver
Autor:
Simon N. Waddington, Richard P. Harbottle, Steven J. Howe, Marcello Niceta, Constantinos Fedonidis, Suet Ping Wong, Orestis Argyros, Charles Coutelle, Oleg Tolmachov
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 89(5)
We have previously described the development of a scaffold/matrix attachment region (S/MAR) episomal vector system for in vivo application and demonstrated its utility to sustain transgene expression in the mouse liver for at least 6 months following
Autor:
Anna Paruzynski, Claudia R. Ball, Alessandro Aiuti, Rafael J. Yáñez-Muñoz, Katrin Faber, Anne Arens, Kamaljit S. Balaggan, Claudia Cattoglio, Daniela Cesana, R Eckenberg, Adrian J. Thrasher, Annette Deichmann, Luigi Naldini, Wei Wang, Manfred Schmidt, Richard Gabriel, Hanno Glimm, Cynthia C. Bartholomae, Odile Cohen-Haguenauer, Luca Biasco, Romy Kirsten, H. Bobby Gaspar, Steven J. Howe, Eugenio Montini, Robin R. Ali, Kerstin Schwarzwaelder, Fulvio Mavilio, Christof von Kalle, Alessandra Recchia, Ali Nowrouzi, William Saurin
Retroviral vectors have induced subtle clonal skewing in many gene therapy patients and severe clonal proliferation and leukemia in some of them, emphasizing the need for comprehensive integration site analyses to assess the biosafety and genomic pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62562880d80b12fab9f6c1204153376b
Autor:
Johnson CS; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Cell Process Development, Cell and Gene Therapy, GlaxoSmithKline, Stevenage, United Kingdom., Williams M; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Sham K; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Belluschi S; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Ma W; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Wang X; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Lau WWY; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Kaufmann KB; Princess Margaret Cancer Center, University Health Network, Toronto, Canada., Krivdova G; Princess Margaret Cancer Center, University Health Network, Toronto, Canada., Calderbank EF; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Mende N; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., McLeod J; Princess Margaret Cancer Center, University Health Network, Toronto, Canada., Mantica G; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Li J; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Grey-Wilson C; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Drakopoulos M; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Basheer S; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Sinha S; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Diamanti E; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Basford C; Cell Process Development, Cell and Gene Therapy, GlaxoSmithKline, Stevenage, United Kingdom., Wilson NK; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Howe SJ; Cell Process Development, Cell and Gene Therapy, GlaxoSmithKline, Stevenage, United Kingdom., Dick JE; Princess Margaret Cancer Center, University Health Network, Toronto, Canada., Göttgens B; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Green AR; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Francis N; Cell Process Development, Cell and Gene Therapy, GlaxoSmithKline, Stevenage, United Kingdom.; Department of Gene Therapy and Regenerative Medicine, King's College London, London, United Kingdom., Laurenti E; Wellcome and Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
Publikováno v:
Blood [Blood] 2024 Aug 15; Vol. 144 (7), pp. 729-741.