Proactive vaccination using multiviral Quartet Nanocages to elicit broad anti-coronavirus responses.

Autor: Hills RA; Department of Biochemistry, University of Oxford, Oxford, UK.; Department of Pharmacology, University of Cambridge, Cambridge, UK., Tan TK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Keeble AH; Department of Biochemistry, University of Oxford, Oxford, UK.; Department of Pharmacology, University of Cambridge, Cambridge, UK., Gnanapragasam PNP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Storm KN; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Rorick AV; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Hill ML; James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Liu S; James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Gilbert-Jaramillo J; James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Afzal M; James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Napier A; James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Admans G; Department of Pharmacology, University of Cambridge, Cambridge, UK., James WS; James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. bjorkman@caltech.edu., Townsend AR; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. alain.townsend@imm.ox.ac.uk.; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK. alain.townsend@imm.ox.ac.uk., Howarth MR; Department of Biochemistry, University of Oxford, Oxford, UK. mh2186@cam.ac.uk.; Department of Pharmacology, University of Cambridge, Cambridge, UK. mh2186@cam.ac.uk.

Publikováno v: Nature nanotechnology [Nat Nanotechnol] 2024 Aug; Vol. 19 (8), pp. 1216-1223. Date of Electronic Publication: 2024 May 06.

Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies.

Autor: King LDW; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Pulido D; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Barrett JR; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Davies H; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Quinkert D; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Lias AM; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Silk SE; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Pattinson DJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Diouf A; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Williams BG; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., McHugh K; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Rodrigues A; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK., Rigby CA; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK., Strazza V; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK., Suurbaar J; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra LG 54, Ghana., Rees-Spear C; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; London School of Hygiene and Tropical Medicine, WC1E 7HT London, UK., Dabbs RA; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Ishizuka AS; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Zhou Y; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Gupta G; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Jin J; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Li Y; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Carnrot C; Novavax AB, Kungsgatan 109, 753 18 Uppsala, Sweden., Minassian AM; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Campeotto I; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK., Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Noe AR; Leidos Life Sciences, Frederick, MD, USA., MacGill RS; Center for Vaccine Innovation and Access, PATH, Washington, DC 20001, USA., King CR; Center for Vaccine Innovation and Access, PATH, Washington, DC 20001, USA., Birkett AJ; Center for Vaccine Innovation and Access, PATH, Washington, DC 20001, USA., Soisson LA; USAID, 1300 Pennsylvania Avenue NW, Washington, DC 20004, USA., Long CA; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Miura K; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Ashfield R; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Skinner K; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Howarth MR; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK., Biswas S; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Draper SJ; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: simon.draper@bioch.ox.ac.uk.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Jul 16; Vol. 5 (7), pp. 101654.