Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Howard W. Whitlock"'
Autor:
Howard W. Whitlock
Publikováno v:
Annals of the New York Academy of Sciences. 112:721-727
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903ced809295de0f5ff3b899ad0c0166
https://doi.org/10.1111/j.1749-6632.1964.tb45050.x
https://doi.org/10.1111/j.1749-6632.1964.tb45050.x
Autor:
Howard W. Whitlock
Publikováno v:
Journal of the American Chemical Society. 123:2127-2133
We explore a model, the "synthesis engine", for synthesis of arbitrarily complex organic structures in the context of library construction of Grignard cycle compounds. We use the simplest possible governing logic and show that random synthesis produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e0eaac55610e50c495fe8e169701d1
https://doi.org/10.1021/ja003199o
https://doi.org/10.1021/ja003199o
Autor:
Howard W. Whitlock
Publikováno v:
The Journal of Organic Chemistry. 63:7982-7989
A chemically intuitive measure (metric) for molecular complexity is described. It is then applied to several syntheses of complex natural products. We conclude that the metric corresponds well with chemical ideas of complexity, and that different syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::321b5889a45c1d81b5b9893c92c9d62d
https://doi.org/10.1021/jo9814546
https://doi.org/10.1021/jo9814546
Autor:
Howard W. Whitlock, Alan B. Brown
Publikováno v:
Synthetic Communications. 23:23-34
The title compound 1 is best made by selective 5-O-propargylation of methyl gentisate, followed by in situ saponification. Direct propargylation of gentisic acid gives a mixture of propargyl ethers, which surprisingly includes the 2-monoether.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89b8d6f74015a077cde6b90422de64d2
https://doi.org/10.1080/00397919308020397
https://doi.org/10.1080/00397919308020397
Autor:
Howard W. Whitlock
Publikováno v:
ChemInform. 30
A chemically intuitive measure (metric) for molecular complexity is described. It is then applied to several syntheses of complex natural products. We conclude that the metric corresponds well with chemical ideas of complexity, and that different syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b99eea768a4654a1e67c96e35c62c7d
https://doi.org/10.1002/chin.199912191
https://doi.org/10.1002/chin.199912191
Publikováno v:
Journal of the American Chemical Society. 112:8931-8941
The synthesis of phosphine oxide bifunctional macrocycles 1-4 is reported. Additionally, the X-ray crystal structures for exo-exo diyne 1 and endo-exo hosts 2 and 4 are presented. The complexation behavior of macrocycles 1-4 and precyclophane with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b9bb84fe9bc9fdd561ad18b9e314e83
https://doi.org/10.1021/ja00180a044
https://doi.org/10.1021/ja00180a044
Autor:
Howard W. Whitlock, Mary J. Cloninger
Publikováno v:
The Journal of organic chemistry. 63(18)
Host 1 binds bicyclic aromatic guests such as 6-nitro-2-naphthol 2, serotonin mimic 3, and stilbene-derivative 4 with high affinity. Competition studies were performed to determine the association constants for complexation of 2−4 by 1. Lower-affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cbbfe92128545b5fa609ba5d8fa15b
https://pubmed.ncbi.nlm.nih.gov/11672245
https://pubmed.ncbi.nlm.nih.gov/11672245
Publikováno v:
Supramolecular Stereochemistry ISBN: 9789401041577
Construction of extremely sticky host molecules, those capable of forming extremely stable complexes with suitable guests, is an interesting and important puzzle. The more important “design principles” for this class of compound are summarized: H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::674c2fd11145cc7067979d6110f06d55
https://doi.org/10.1007/978-94-011-0353-4_14
https://doi.org/10.1007/978-94-011-0353-4_14
Autor:
null Jr, Howard W. Whitlock
This project involves the synthesis of molecules containing concave functional groups capable of supporting chemical reactions. Salient sub-problems have to do with the distinction between steric encumbrance and steric hindrance, and with development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8b1e33693e4bc701c0c1c3af833b5b8
https://doi.org/10.21236/ada251024
https://doi.org/10.21236/ada251024
Publikováno v:
ChemInform. 21
Synthese de dioxo hexamethylenedioxy-p-phenylene tetraoxadiphospha [8] paracyclo [1] paracyclo [8] paracyclo [1] paracyclophane a partir d'oxyde de tri-[hydroxy-4 phenyl] phosphine et de bromo-3 propyne-2 ol-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87c5d0f26ddd034db0d32aa525426362
https://doi.org/10.1002/chin.199012264
https://doi.org/10.1002/chin.199012264