Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Howard W. Chambers"'
Publikováno v:
Journal of Toxicology, Vol 2015 (2015)
Paraoxonase (PON1) is a calcium dependent enzyme that is capable of hydrolyzing organophosphate anticholinesterases. PON1 activity is present in most mammals and previous research established that PON1 activity differs depending on the species. These
Externí odkaz:
https://doaj.org/article/5cdccf692aed4d7f929b9392a9d37c2d
Autor:
Russell. L. Carr, Howard W. Chambers, Janice E. Chambers, Seth F. Oppenheimer, Jason R. Richardson
Publikováno v:
Electronic Journal of Differential Equations, Vol Conference, Iss 10, Pp 89-99 (2003)
The organophosphorus (OP) insecticides are one of the most widely used and important insecticide classes. These insecticides exert toxicity through inhibition of the critical nervous system enzyme cholinesterase (ChE) which functions to rapidly destr
Externí odkaz:
https://doaj.org/article/c5d10442b8d5406d8c748759c36b0057
Publikováno v:
Drug Chem Toxicol
Novel-substituted phenoxyalkyl pyridinium oxime acetylcholinesterase (AChE) reactivators (US patent 9,227,937) that showed convincing evidence of penetration into the brains of intact rats were developed by our laboratories. The oximes separated into
Autor:
Janice E. Chambers, Matthew K. Ross, Kristen E. Funck, Howard W. Chambers, Ronald B. Pringle, Edward C. Meek
Publikováno v:
Chemico-Biological Interactions. 259:154-159
Pyridinium oximes are strong nucleophiles and many are effective reactivators of organophosphate-inhibited cholinesterase (ChE). However, the current oxime reactivators are ineffective at crossing the blood-brain barrier and reactivating brain ChE in
The nerve agents are extremely toxic organophosphates which lead to massive inhibition of acetylcholinesterase (AChE) in both the central and peripheral nervous systems. The currently approved pyridinium oxime reactivators of organophosphate-inhibite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c32dc760b11d42f76b3532dc78c060
https://europepmc.org/articles/PMC6260155/
https://europepmc.org/articles/PMC6260155/
Publikováno v:
Toxicology Letters. 248:39-45
Because testing of nerve agents is limited to only authorized facilities, our laboratory developed several surrogates that resemble nerve agents because they phosphylate the acetylcholinesterase (AChE) with the same moiety as the actual nerve agents.
Autor:
C. Andrew Leach, W.Shane Bennett, Ronald B. Pringle, Joshua P. Bennett, Robert W. Wills, Howard W. Chambers, Janice E. Chambers, Edward C. Meek
Publikováno v:
Toxicology. 339:51-57
Novel substituted phenoxyalkyl pyridinium oximes, previously shown to reactivate brain cholinesterase in rats treated with high sublethal dosages of surrogates of sarin and VX, were tested for their ability to prevent mortality from lethal doses of t
Publikováno v:
Toxicology. 336:79-83
Novel nucleophiles, a series of substituted phenoxyalkyl pyridinium oximes, have been previously shown by our laboratories to enhance in vitro paraoxonase 1 (PON1)-mediated degradation of a sarin surrogate (nitrophenyl isopropyl methylphosphonate, NI
Autor:
Kristen E. Funck, Manikanthan Bhavaraju, Ronald B. Pringle, Steven R. Gwaltney, Edward C. Meek, Howard W. Chambers, Janice E. Chambers
Publikováno v:
Toxicological Sciences. 143:46-53
Paraoxonase 1 (PON1) is a calcium-dependent hydrolase associated with serum high-density lipoprotein particles. PON1 hydrolyzes some organophosphates (OPs), including some nerve agents, through nucleophilic attack of hydroxide ion (from water) in the
Autor:
Howard W. Chambers, Mary Beth Dail, Chiquita Y. McDaniel, Janice E. Chambers, Robert W. Wills
Publikováno v:
Biochemical Genetics. 52:509-523
Paraoxonase (PON1) hydrolyzes paraoxon (PO) and diazoxon (DZO), active metabolites of insecticides parathion and diazinon. The PON1 gene has single nucleotide polymorphisms (SNPs) including a codon 192 arginine (R) to glutamine (Q) and methionine (M)