Stakeholders’ perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study

Autor: Matthew Peak, Michael Griksaitis, Clare Fowler, Simon Gates, Christopher Lamb, Elizabeth Deja, Rachel Agbeko, John Pappachan, Helen Parker, Jennifer Preston, Ahmed Osman, Paula Williamson, Paul S McNamara, David Armstrong, Tracy Moitt, Ramesh Kumar, John Alexander, Kevin P Morris, Roger Parslow, Steve Cunningham, Craig Knott, Chloe Donohue, Catrin Barker, Julie Richardson, Ashley Jones, Stephanie Clarke, Malcolm G Semple, Richard Levin, James Weitz, Natasha Roberts, Vanessa Compton, Kentigern Thorburn, PHILIP MILNER, Howard W Clark, Bessie Cipriano, Nosheen Khalid, Nicolene Plaatjies, Avishay Sarfatti, Mark Terris, Santosh Sundararajan, Edgar Brincat, Natasha Thorn, Ramiya Kirupananthan, Peter J Davis, Samantha Owen, Pavanasam Ramesh, Sarah Fox, Laura Price, Hannah Clarke, Charlotte Thompson, Wendy Browne, Christine Mackerness, Laura Rad, Grace Williamson, Simone Paulson, Laura O'Malley, Zoe Oliver, Evette Allen, Clare van Miert, Ashley Best, Jens Madsen, Anne Dawson, Colin Summers, Blessing Osaghae, Madhuri Panchal, Anthony Postle, Peter Jirasek, Dawn Jones, Michael Mander, Laura Rimmer, Paul C Ritson, Chris Simons, Afeda Mohamed Ali, Cara Alexander, Hannah Child, Natalie Milburn, Holly Parkin, Harriet Payne, Carly Tooke, Helen Winmill, Katherine Baptiste, Sophie Coles, Sarah-Jayne Eames, Christina Linton, Helen Marley, Sarah Mogan, Alvin Schadenberg, John Stiven, Rob Claydon, Anna Stancombe, Kate Teeley, Kathryn Reeves, Emily Scriven, Raghu N Ramaiah, Rekha Patel, Patrick E Davies, Lindsay Crate, Kirsten Beadon, Rachel McMinnis, Frances Sinfield, Hilary Callaghan, Vicki Linton, Jeremy Lyons, Clara Nelson, Tsz-YanMilly Lo, Jackie McCormick, Andrea Wood, Ross Marscheider, Stephen D Playfor, Bernadette C Gavin, Dave J Morgan, Lara T Bunni, Claire F Jennings, Rebecca Marshall, Emma K Riley, Lorena Caruana, Amber Cook, Tracey Curtis, Nichola Etherington, Jenni McCorkell, Christie Mellish, Jenny Pond, Catherine Postlethwaite, Nicola McClelland, Holly Minchin, Joanne Tomlinson, Simona Lampariello, Tara Murray, Olivia Nugent, Samantha Reed, Christa Ronan, Salman Siddiqi

Publikováno v: BMJ Open, Vol 14, Iss 1 (2024)

Objectives The Bronchiolitis Endotracheal Surfactant Study (BESS) is a randomised controlled trial to determine the efficacy of endo-tracheal surfactant therapy for critically ill infants with bronchiolitis. To explore acceptability of BESS, includin

Externí odkaz: https://doaj.org/article/3170ef8f62a14d658eb8ae20a8d2b6ee

Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides reveals alternative binding modes for the same LPS.

Autor: Jamie R Littlejohn, Ruben F da Silva, William A Neale, Carrie C Smallcombe, Howard W Clark, Rose-Marie A Mackay, Alastair S Watson, Jens Madsen, Derek W Hood, Ian Burns, Trevor J Greenhough, Annette K Shrive

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0199175 (2018)

The crystal structures of a biologically and therapeutically active recombinant homotrimeric fragment of native human SP-D (hSP-D) complexed with the inner core oligosaccharide of the Salmonella enterica sv Minnesota rough strains R5 and R7 (rough mu

Externí odkaz: https://doaj.org/article/bb4c5452dabd479a9307265d0e82ba5b

Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD

Autor: Ventzislava A. Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S. Glover, Jodie Ackland, Bastian Angerman, Graham Belfield, Maria G. Belvisi, Hannah Burke, Doriana Cellura, Howard W. Clark, Damla Etal, Anna Freeman, Ashley I Heinson, Sonja Hess, Michael Hühn, Emily Hall, Alex Mackay, Jens Madsen, Christopher McCrae, Daniel Muthas, Steven Novick, Kristoffer Ostridge, Lisa Öberg, Adam Platt, Anthony D. Postle, C. Mirella Spalluto, Outi Vaarala, Junmin Wang, Karl J. Staples, Tom M.A Wilkinson

Publikováno v: ERJ Open Research. :00378-2022

RationalePulmonary surfactant is vital for lung homeostasis as it reduces surface tension to prevent alveolar collapse and provides essential immune-regulatory and anti-pathogenic functions. Previous studies demonstrated dysregulation of some individ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9bb1119b4ab9577c42fa13930178e3c
https://doi.org/10.1183/23120541.00378-2022

Success of blinding a procedural intervention in a randomised controlled trial in preterm infants receiving respiratory support

Autor: Elizabeth Reid, Omar F Kamlin, Francesca Orsini, Antonio G De Paoli, Howard W Clark, Roger F Soll, John B Carlin, Peter G Davis, Peter A Dargaville

Publikováno v: Clinical Trials. :174077452311716

Background: Blinding of treatment allocation from treating clinicians in neonatal randomised controlled trials can minimise performance bias, but its effectiveness is rarely assessed. Methods: To examine the effectiveness of blinding a procedural int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35ad1279584bd47a33f5c11c90024d40
https://doi.org/10.1177/17407745231171647

Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial

Autor: Peter A, Dargaville, C Omar F, Kamlin, Francesca, Orsini, Xiaofang, Wang, Antonio G, De Paoli, H Gozde, Kanmaz Kutman, Merih, Cetinkaya, Lilijana, Kornhauser-Cerar, Matthew, Derrick, Hilal, Özkan, Christian V, Hulzebos, Georg M, Schmölzer, Ajit, Aiyappan, Brigitte, Lemyre, Sheree, Kuo, Victor S, Rajadurai, Joyce, O'Shea, Manoj, Biniwale, Rangasamy, Ramanathan, Alla, Kushnir, David, Bader, Mark R, Thomas, Mallinath, Chakraborty, Mariam J, Buksh, Risha, Bhatia, Carol L, Sullivan, Eric S, Shinwell, Amanda, Dyson, David P, Barker, Amir, Kugelman, Tim J, Donovan, Markus K, Tauscher, Vadivelam, Murthy, Sanoj K M, Ali, Pete, Yossuck, Howard W, Clark, Roger F, Soll, John B, Carlin, Peter G, Davis, Susan L, Collins

Publikováno v: JAMA
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 326(24), 2478-2487. AMER MEDICAL ASSOC

IMPORTANCE The benefits of surfactant administration via a thin catheter (minimally invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome are uncertain.OBJECTIVE To examine the effect of selective application of MI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf260739e007481a4562b1a545b7691
https://europepmc.org/articles/PMC8715350/