Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Howard Tucker"'
Autor:
John S. Shaw, Martin Wild, Dearg S. Brown, Howard Tucker, Adrian John Highton, Alan Wellington Faull, John Oldfield, John G. Cumming, Colin Fielding, Stuart L. Wells
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1655-1659
Modifications to a series of potent and selective substituted 1-(3,3-diphenylpropyl)-piperidine phenylacetamide CCR5 antagonists were explored with the aim of reducing affinity at the hERG cardiac ion channel. Replacement of one aromatic ring in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47156f455ebb21c57218d55733038a3
https://doi.org/10.1016/j.bmcl.2011.12.117
https://doi.org/10.1016/j.bmcl.2011.12.117
Autor:
Howard Tucker
Takes A Fresh Look At Leslie Nielsen. This book is your ultimate resource for Leslie Nielsen. Here you will find the most up-to-date 174 Success Facts, Information, and much more.In easy to read chapters, with extensive references and links to get yo
Autor:
Dudley F. Thomas, Howard Tucker
Publikováno v:
Journal of Medicinal Chemistry. 35:804-807
A series of 5-[(arylcarbonyl)amino]- and 5-(arylcarbamoyl)pyridine-2-carboxylic acids has been prepared and tested for activity as inhibitors of the enzyme prolyl 4-hydroxylase (EC 1.14.11.2). All the analogues prepared were inhibitors of the enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc1cb3ef8a31809a1f20f893810048d
https://doi.org/10.1021/jm00083a002
https://doi.org/10.1021/jm00083a002
Autor:
John S. Shaw, Howard Tucker, Emma Shepherd, Flynn Anthony P, Anne Cooper, Ken Grime, Alan Wellington Faull, John Oldfield, John G. Cumming, Simon J. Brown, David Whittaker
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(13)
SAR and PK studies led to the identification of N-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-methanesulfonylphenyl] propyl}piperidin-4-yl)-N-ethyl-2-[4-methanesulfonylphenyl]acetamide as a highly potent and selective ligand for the human CCR5 chemokine rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5053f1d628c46bf7ecd1c0e97833437
https://pubmed.ncbi.nlm.nih.gov/16631366
https://pubmed.ncbi.nlm.nih.gov/16631366
Autor:
John S. Shaw, Anne Cooper, Jon Winter, Ken Grime, Howard Tucker, Chris Logan, John Oldfield, Sharon McLaughlin, John G. Cumming, David Whittaker
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(22)
SAR and DMPK studies led to the identification of substituted N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides as potent and orally bioavailable ligands for the human CCR5 chemokine receptor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5e161fbc0793c8580ea4844843004c
https://pubmed.ncbi.nlm.nih.gov/16154744
https://pubmed.ncbi.nlm.nih.gov/16154744
Publikováno v:
Steroids. 65(10-11)
From the dual progestin/antiandrogenic properties of certain synthetic steroids (e.g. cyproterone acetate), it was apparent that the progesterone (P) and androgen (A) receptors must have some common ligand binding features. The nonsteroidal antiandro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45bf03156b92cd15d87f0d390e85b09
https://pubmed.ncbi.nlm.nih.gov/11108883
https://pubmed.ncbi.nlm.nih.gov/11108883
Publikováno v:
Journal of Medicinal Chemistry. 31:954-959
A series of 3-(substituted thio)-2-hydroxypropionanilides and some corresponding sulfones and sulfoxides of general structure 7, in which R' is methyl or trifluoromethyl, were prepared and tested for antiandrogen activity. Members of the trifluoromet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a04abd0e8ba43caccd88762c3fb46e3
https://doi.org/10.1021/jm00400a011
https://doi.org/10.1021/jm00400a011
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1545-1548
(E)-2-Benzylidene-(Z)-1-mesityl(phenyl)methyleneindane cyclises by a disrotatory mode at 180 °C to give cis-9a,10-dihydro-5,10-diphenyl-6,8,9a-trimethyl-11H-benzo[b]fluorene, which, at this temperature, undergoes two ‘forbidden’ processes in con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed436eb39d155514c27bdb6b49fddf0f
https://doi.org/10.1039/p19750001545
https://doi.org/10.1039/p19750001545
Autor:
Howard Tucker
Publikováno v:
The Journal of Organic Chemistry. 44:2943-2945
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f50d529f533001ef2bdd53cb34b9d00
https://doi.org/10.1021/jo01330a027
https://doi.org/10.1021/jo01330a027