Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Howard T. Petrie"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
One aspect of ageing on immunity is attributed to accelerated thymic atrophy, but the underlying mechanism is still lacking. Here the authors show, using conditional reporter mouse models, that both atrophy and regeneration of the thymus are regulate
Externí odkaz:
https://doaj.org/article/df914271f29b44e993752f1172f879f4
Autor:
Ann V. Griffith, Thomas Venables, Jianjun Shi, Andrew Farr, Holly van Remmen, Luke Szweda, Mohammad Fallahi, Peter Rabinovitch, Howard T. Petrie
Publikováno v:
Cell Reports, Vol 12, Iss 7, Pp 1071-1079 (2015)
T lymphocytes are essential mediators of immunity that are produced by the thymus in proportion to its size. The thymus atrophies rapidly with age, resulting in progressive diminution of new T cell production. This decreased output is compensated by
Externí odkaz:
https://doaj.org/article/dfea9ee59cf5442fba068048f8e21d91
Autor:
Susan E. Prockop, Howard T. Petrie
Publikováno v:
Clinical and Developmental Immunology, Vol 11, Iss 2, Pp 135-141 (2004)
T cell differentiation in the thymus depends on sequential interactions between lymphoid progenitors and stromal cells in discrete regions of the cortex. Here, we show that despite αEβ7 expression by a subset of the earliest intrathymic precurso
Externí odkaz:
https://doaj.org/article/118d22dafdd344129a34643835187e54
Publikováno v:
Clinical and Developmental Immunology, Vol 10, Iss 1, Pp 27-33 (2003)
T cell progenitors derive from the bone marrow but must migrate via bloodstream to the thymus in order to differentiate. The mechanism by which the thymus recruits progenitors from the blood is unknown. It is known, however, that there are receptive
Externí odkaz:
https://doaj.org/article/6af736e95d5a48e9b1792ab1641e0447
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
T lymphocytes must be produced throughout life, yet the thymus, where T lymphocytes are made, exhibits accelerated atrophy with age. Even in advanced atrophy, however, the thymus remains plastic, and can be regenerated by appropriate stimuli. Logical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7c98ff61f7f62c0368c9f8c3d9d5cc
https://pubmed.ncbi.nlm.nih.gov/31562306
https://pubmed.ncbi.nlm.nih.gov/31562306
Publikováno v:
Immunology and cell biology
V-(D)-J recombination generates the antigen receptor diversity necessary for immune cell function while allelic exclusion ensures that each cell expresses a single antigen-receptor. V-(D)-J recombination of the Ig, Tcrb, Tcrg, and Tcrd antigen recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212b983cdef8aec710a7195ba05cfbf3
https://pubmed.ncbi.nlm.nih.gov/28244489
https://pubmed.ncbi.nlm.nih.gov/28244489
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166967 (2016)
PLoS ONE
PLoS ONE
Foxn1 (forkhead box N1), also known as the nude gene or winged-helix nude (Whn), is a forkhead transcription factor thought to be restricted to keratinocytes in the skin and thymus. Consistent with this tissue distribution, spontaneous or targeted mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45c983ffffbb325c949836baf234967
http://europepmc.org/articles/PMC5120802?pdf=render
http://europepmc.org/articles/PMC5120802?pdf=render
Publikováno v:
Blood. 118:2511-2519
Notch1 signaling is absolutely essential for steady-state thymic lymphopoiesis, but the role of other Notch receptors, and their potential overlap with the function of Notch1, remains unclear. Here we show that like Notch1, Notch3 is differentially e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfdb404fb664da37cb9a701dd173a9e
https://doi.org/10.1182/blood-2011-04-346726
https://doi.org/10.1182/blood-2011-04-346726
Publikováno v:
Bioinformatics. 23:3328-3334
Motivation: Biological samples frequently contain multiple cell-types that each can play a crucial role in the development and/or regulation of adjacent cells or tissues. The search for biomarkers, or expression patterns of, one cell-type in those sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6adabd396c9ceec1ca0c11e4ae8b559
https://doi.org/10.1093/bioinformatics/btm508
https://doi.org/10.1093/bioinformatics/btm508
Publikováno v:
Immunity. 26:678-689
T cells developing in the thymus are derived from hematopoietic stem cells (HSCs) in the bone marrow (BM). Understanding the developmental steps linking multipotent HSCs to intrathymic T lineage-committed progenitors is important for understanding ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c30ba113ffeb880fcc7f0d1e6bc02b7
https://doi.org/10.1016/j.immuni.2007.05.009
https://doi.org/10.1016/j.immuni.2007.05.009