Metabolism of steroidal lactones by the fungus Corynespora cassiicola CBS 161.60 results in a mechanistically unique intramolecular ring-D cyclization resulting in C-14 spiro-lactones

Autor: Howard T. Dodd, Yewande Inatimi Oni, Megan Uttley, A. Christy Hunter, John M. Gardiner, James Raftery

Publikováno v: Hunter, A C, Oni, Y I, Dodd, H T, Raftery, J, Gardiner, J M & Uttley, M 2017, ' Metabolism of steroidal lactones by the fungus Corynespora cassiicola CBS 161.60 results in a mechanistically unique intramolecular ring-D cyclization resulting in C-14 spiro-lactones ', Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, vol. 1862, no. 9, pp. 939-945 . https://doi.org/10.1016/j.bbalip.2017.06.003

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. The fungus Corynespora cassiicola metabolises exogenous steroids in a unique and highly specific manne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0813496d796c3c570efc8b4dbad97f9d
https://doi.org/10.1016/j.bbalip.2017.06.003

Transformation of some 3α-substituted steroids by Aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway

Autor: Howard T. Dodd, Cinzia Dedi, Patrice Barrett, A. Christy Hunter, Hedda Khuenl-Brady

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 118:171-176

Aspergillus tamarii contains an endogenous lactonization pathway which can transform progesterone to testololactone in high yield through a sequential four step enzymatic pathway. In this pathway testosterone is formed which primarily undergoes oxida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf620e62650ed977d614ad67ff5208c3
https://doi.org/10.1016/j.jsbmb.2009.12.003

Transformation of 5-ene steroids by the fungus Aspergillus tamarii KITA: Mixed molecular fate in lactonization and hydroxylation pathways with identification of a putative 3β-hydroxy-steroid dehydrogenase/Δ5–Δ4 isomerase pathway

Autor: Howard T. Dodd, Emma Coyle, Salome Juliette Koussoroplis, Cinzia Dedi, Fiona Morse, A. Christy Hunter

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1791:110-117

The fungus Aspergillus tamarii metabolizes progesterone to testololactone in high yield through a sequential four step enzymatic pathway which, has demonstrated flexibility in handling a range of steroidal probes. These substrates have revealed that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611912b930238ea8782a44af3e1f01d1
https://doi.org/10.1016/j.bbalip.2008.12.005

Aminosalicylic acid conjugates of EDTA as potential anti-inflammatory pro-drugs: synthesis, copper chelation and superoxide dismutase-like activities

Autor: Declan P. Naughton, Mark A Bailey, Ken J. Rutt, Matthew J. Ingram, Howard T. Dodd

Publikováno v: Transition Metal Chemistry. 33:195-202

Aminosalicylic acids have been used to combat inflammatory bowel diseases (IBDs) for over 60 years. In this report, spectroscopic studies on the Cu(II) complexation behaviour of the newly synthesised chelator ethylenediaminetetraacetic acid bis-(4-am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7505644d736f22c65c77e71ade20eb30
https://doi.org/10.1007/s11243-007-9031-1

Complement fixing cross reactivity between Histoplasma capsulatum and certain form-related aleuriosporic hyphomycetes

Autor: Miriam Li, Robert G. Garrison, Howard T. Dodd

Publikováno v: Mycopathologia et Mycologia Applicata. 33:353-363

The complement fixation test is the most widely accepted technique employed from the serologic diagnosis and study of histoplasmosis. Results obtained in this study indicate significant CF cross reactivity between standardHistoplasma CF antigens and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153e2b981d7c9530f3494268599c8018
https://doi.org/10.1007/bf02088927