Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Howard T, Jacobs"'
Autor:
Mügen Terzioglu, Kristo Veeroja, Toni Montonen, Teemu O Ihalainen, Tiina S Salminen, Paule Bénit, Pierre Rustin, Young-Tae Chang, Takeharu Nagai, Howard T Jacobs
Publikováno v:
eLife, Vol 12 (2023)
Based on studies with a fluorescent reporter dye, Mito Thermo Yellow (MTY), and the genetically encoded gTEMP ratiometric fluorescent temperature indicator targeted to mitochondria, the temperature of active mitochondria in four mammalian and one ins
Externí odkaz:
https://doaj.org/article/582ec16ea6924628942e3d6071e8abc5
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 13, Iss 6 (2023)
AbstractThe Drosophila tko25ttko25tw1118whitew1118tko25ttko25ttko25tw1118tkotko25ttko25t
Externí odkaz:
https://doaj.org/article/164c3bb6990f4f3cb3a29feaf457475e
Autor:
Jack George, Tea Tuomela, Esko Kemppainen, Antti Nurminen, Samuel Braun, Cagri Yalgin, Howard T. Jacobs
Publikováno v:
Fly, Vol 13, Iss 1-4, Pp 12-28 (2019)
The Drosophila bang-sensitive mutant tko25t, manifesting a global deficiency in oxidative phosphorylation due to a mitochondrial protein synthesis defect, exhibits a pronounced delay in larval development. We previously identified a number of metabol
Externí odkaz:
https://doaj.org/article/95f7a6c5ad4842c49eb40e9a42c0080d
Autor:
Tiina S. Salminen, Giuseppe Cannino, Marcos T. Oliveira, Päivi Lillsunde, Howard T. Jacobs, Laurie S. Kaguni
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2225-2234 (2019)
Drosophila melanogaster, like most animal species, displays considerable genetic variation in both nuclear and mitochondrial DNA (mtDNA). Here we tested whether any of four natural mtDNA variants was able to modify the effect of the phenotypically mi
Externí odkaz:
https://doaj.org/article/ee17888e1aa0495288cf572b578edc6f
Autor:
Jayasimman Rajendran, Janne Purhonen, Saara Tegelberg, Olli‐Pekka Smolander, Matthias Mörgelin, Jan Rozman, Valerie Gailus‐Durner, Helmut Fuchs, Martin Hrabe de Angelis, Petri Auvinen, Eero Mervaala, Howard T Jacobs, Marten Szibor, Vineta Fellman, Jukka Kallijärvi
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 1, Pp 1-19 (2018)
Abstract Alternative oxidase (AOX) is a non‐mammalian enzyme that can bypass blockade of the complex III‐IV segment of the respiratory chain (RC). We crossed a Ciona intestinalis AOX transgene into RC complex III (cIII)‐deficient Bcs1lp.S78G kn
Externí odkaz:
https://doaj.org/article/4482183c413e432b817baa4364affa08
Autor:
Cagri Yalgin, Bohdana Rovenko, Ana Andjelković, Margot Neefjes, Burak Oymak, Eric Dufour, Ville Hietakangas, Howard T. Jacobs
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101362- (2020)
Summary: Dopaminergic (DA) neurons have been implicated as key targets in neurological disorders, notably those involving locomotor impairment, and are considered to be highly vulnerable to mitochondrial dysfunction, a common feature of such diseases
Externí odkaz:
https://doaj.org/article/002f6f5a2ec14c7b8032eb8cfdb084db
Autor:
Ana Paula C. Rodrigues, André F. Camargo, Ana Andjelković, Howard T. Jacobs, Marcos T. Oliveira
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The xenotopic expression of the alternative oxidase AOX from the tunicate Ciona intestinalis in diverse models of human disease partially alleviates the phenotypic effects of mitochondrial respiratory chain defects. AOX is a non-proton pumpi
Externí odkaz:
https://doaj.org/article/8d4f904e88654e5884d32d4206b5cd34
Autor:
Marten Szibor, Praveen K. Dhandapani, Eric Dufour, Kira M. Holmström, Yuan Zhuang, Isabelle Salwig, Ilka Wittig, Juliana Heidler, Zemfira Gizatullina, Timur Gainutdinov, German Mouse Clinic Consortium, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Jatin Nandania, Vidya Velagapudi, Astrid Wietelmann, Pierre Rustin, Frank N. Gellerich, Howard T. Jacobs, Thomas Braun
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 2, Pp 163-171 (2017)
Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping. Thus, they maintain electron flow
Externí odkaz:
https://doaj.org/article/723f62cecb1f4bc78341cbec0e109669
Autor:
Diana Bahhir, Cagri Yalgin, Liina Ots, Sampsa Järvinen, Jack George, Alba Naudí, Tatjana Krama, Indrikis Krams, Mairi Tamm, Ana Andjelković, Eric Dufour, Jose M González de Cózar, Mike Gerards, Mikael Parhiala, Reinald Pamplona, Howard T Jacobs, Priit Jõers
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008410 (2019)
Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosoph
Externí odkaz:
https://doaj.org/article/c367ecdb264e415a939fdddc23efbe38
Autor:
Jack George, Howard T. Jacobs
Publikováno v:
Biology Open, Vol 8, Iss 7 (2019)
PGC-1α and its homologues have been proposed to act as master regulators of mitochondrial biogenesis in animals. Most relevant studies have been conducted in mammals, where interpretation is complicated by the fact that there are three partially red
Externí odkaz:
https://doaj.org/article/4cb39ec0b23b4849a146777395ffc884